Biology:CD180
 Generic protein structure example |
CD180 antigen is a protein that in humans is encoded by the CD180 gene.[1][2][3][4]
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans (1988) and mice (1994), respectively. CD180 is expressed on antigen presenting cells including B cells and dendritic cells. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.[3]
Recently, CD180 has been demonstrated to be involved in the survival and prognosis of B-cell chronic lymphocytic leukemia.[5][6]
References
- ↑ "RP105 is associated with MD-1 and transmits an activation signal in human B cells". Blood 92 (8): 2815–22. Nov 1998. doi:10.1182/blood.V92.8.2815. PMID 9763566.
- ↑ "Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)". Genomics 38 (3): 299–304. Mar 1997. doi:10.1006/geno.1996.0632. PMID 8975706.
- ↑ 3.0 3.1 "Entrez Gene: CD180 CD180 molecule". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4064.
- ↑ [yes|permanent dead link|dead link}}] [4]
- ↑ Porakishvili, Nino; Memon, Azka; Vispute, Ketki; Kulikova, Nina; Clark, Edward A.; Rai, Kanti R.; Nathwani, Amit; Damle, Rajendra N. et al. (May 2011). "CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells" (in en). British Journal of Haematology 153 (4): 486–498. doi:10.1111/j.1365-2141.2011.08605.x. ISSN 0007-1048. PMID 21443749.
- ↑ Gordiienko, Inna; Shlapatska, Larysa; Kholodniuk, Valeriia; Sklyarenko, Lilia; Gluzman, Daniel F.; Clark, Edward A.; Sidorenko, Svetlana P. (2017-10-05). "The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling" (in en). PLOS ONE 12 (10): e0185940. doi:10.1371/journal.pone.0185940. ISSN 1932-6203. PMID 28982149. Bibcode: 2017PLoSO..1285940G.
Further reading
- "Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis.". J. Hepatol. 47 (3): 404–11. 2007. doi:10.1016/j.jhep.2007.03.012. PMID 17448566.
- "Negative Regulation of TLR4 Signaling by RP105". Nat. Immunol. 6 (6): 571–8. 2005. doi:10.1038/ni1198. PMID 15852007.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. 2005. doi:10.1110/ps.04682504. PMID 15340161.
- "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. 2003. doi:10.1038/nm822. PMID 12539042.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression". J. Immunol. 161 (3): 1348–53. 1998. doi:10.4049/jimmunol.161.3.1348. PMID 9686597.
External links
- Human CD180 genome location and CD180 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: Q99467 (Human CD180 antigen) at the PDBe-KB.
- Overview of all the structural information available in the PDB for UniProt: Q62192 (Mouse CD180 antigen) at the PDBe-KB.
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