Biology:Centaurin, alpha 1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Arf-GAP with dual PH domain-containing protein 1 is a protein that in humans is encoded by the ADAP1 gene.[1][2]
Interactions
Centaurin, alpha 1 has been shown to interact with:
- Casein kinase 1, alpha 1[3][4]
- Nucleolin,[5]
- P110α,[6]
- PRKCI,[6]
- Protein kinase D1,[6] and
- Protein kinase Mζ.[6]
References
- ↑ "Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1". The Biochemical Journal 340 (2): 359–63. Jun 1999. doi:10.1042/0264-6021:3400359. PMID 10333475.
- ↑ "Entrez Gene: CENTA1 centaurin, alpha 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11033.
- ↑ "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters 517 (1–3): 167–71. Apr 2002. doi:10.1016/s0014-5793(02)02614-5. PMID 12062430.
- ↑ "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins". The Journal of Biological Chemistry 276 (22): 18757–64. Jun 2001. doi:10.1074/jbc.M010005200. PMID 11278595.
- ↑ "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin". Biochemical and Biophysical Research Communications 301 (2): 502–8. Feb 2003. doi:10.1016/s0006-291x(02)03010-3. PMID 12565890.
- ↑ 6.0 6.1 6.2 6.3 "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochemical and Biophysical Research Communications 307 (3): 459–65. Aug 2003. doi:10.1016/s0006-291x(03)01187-2. PMID 12893243.
Further reading
- "Molecular cloning and functional characterization of a human homologue of centaurin-alpha". Biochemical and Biophysical Research Communications 262 (1): 237–44. Aug 1999. doi:10.1006/bbrc.1999.1065. PMID 10448098.
- "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins". The Journal of Biological Chemistry 276 (22): 18757–64. Jun 2001. doi:10.1074/jbc.M010005200. PMID 11278595.
- "Cellular expression and subcellular localization of the human Ins(1,3,4,5)P(4)-binding protein, p42(IP4), in human brain and in neuronal cells". Brain Research. Molecular Brain Research 99 (1): 1–11. Feb 2002. doi:10.1016/S0169-328X(01)00335-7. PMID 11869802.
- "Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle". European Journal of Cell Biology 81 (4): 222–30. Apr 2002. doi:10.1078/0171-9335-00242. PMID 12018390.
- "Neurons and plaques of Alzheimer's disease patients highly express the neuronal membrane docking protein p42IP4/centaurin alpha". NeuroReport 13 (18): 2417–9. Dec 2002. doi:10.1097/00001756-200212200-00008. PMID 12499840.
- "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin". Biochemical and Biophysical Research Communications 301 (2): 502–8. Feb 2003. doi:10.1016/S0006-291X(02)03010-3. PMID 12565890.
- "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene 22 (21): 3307–18. May 2003. doi:10.1038/sj.onc.1206406. PMID 12761501.
- "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochemical and Biophysical Research Communications 307 (3): 459–65. Aug 2003. doi:10.1016/S0006-291X(03)01187-2. PMID 12893243.
- "Centaurin-alpha1 is an in vivo phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein for ARF6 that is involved in actin cytoskeleton organization". The Journal of Biological Chemistry 279 (8): 6205–8. Feb 2004. doi:10.1074/jbc.C300482200. PMID 14625293. http://www.jbc.org/content/279/8/6205.full.pdf.
- "Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins". Journal of Neurochemistry 88 (2): 326–36. Jan 2004. doi:10.1046/j.1471-4159.2003.02143.x. PMID 14690521.
- "Altered expression of protein p42IP4/centaurin-alpha 1 in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin". NeuroReport 15 (1): 147–8. Jan 2004. doi:10.1097/00001756-200401190-00028. PMID 15106847.
- "The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton". European Journal of Cell Biology 83 (10): 541–54. Oct 2004. doi:10.1078/0171-9335-00416. PMID 15679100.
- "Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization". Molecular Pharmacology 67 (6): 1822–8. Jun 2005. doi:10.1124/mol.105.011338. PMID 15778454.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Centaurin-alpha1 is a phosphatidylinositol 3-kinase-dependent activator of ERK1/2 mitogen-activated protein kinases". The Journal of Biological Chemistry 281 (3): 1332–7. Jan 2006. doi:10.1074/jbc.M505905200. PMID 16287813.
- "p42(IP4)/centaurin alpha1, a brain-specific PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding protein: membrane trafficking induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor". Neurochemical Research 30 (10): 1319–30. Oct 2005. doi:10.1007/s11064-005-8804-1. PMID 16341594.
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