Biology:PRKCI
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.[1][2][3]
Function
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbol esters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.[3]
Interactions
PRKCI has been shown to interact with:
- Centaurin, alpha 1,[4]
- FRS2,[5]
- Glyceraldehyde 3-phosphate dehydrogenase,[6]
- PARD3,[7][8]
- Phosphoinositide-dependent kinase-1,[9]
- SMG1 (gene),[10]
- Sequestosome 1,
- KRAS.[11]
- Vimentin[12]
References
- ↑ "Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3". Genomics 26 (3): 629–31. Apr 1995. doi:10.1016/0888-7543(95)80190-W. PMID 7607695.
- ↑ "The assignment of PRKCI to bovine chromosome 1q34-->q36 by FISH suggests a new assignment to human chromosome 3". Cytogenetics and Cell Genetics 95 (1–2): 79–81. April 2002. doi:10.1159/000057021. PMID 11978974.
- ↑ 3.0 3.1 "Entrez Gene: PRKCI protein kinase C, iota". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5584.
- ↑ "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochemical and Biophysical Research Communications 307 (3): 459–65. Aug 2003. doi:10.1016/s0006-291x(03)01187-2. PMID 12893243.
- ↑ "Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling". The Journal of Biological Chemistry 274 (27): 19025–34. Jul 1999. doi:10.1074/jbc.274.27.19025. PMID 10383403.
- ↑ "Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway". The Journal of Biological Chemistry 277 (5): 3334–41. Feb 2002. doi:10.1074/jbc.M109744200. PMID 11724794.
- ↑ "Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62". Molecular and Cellular Biology 18 (5): 3069–80. May 1998. doi:10.1128/mcb.18.5.3069. PMID 9566925.
- ↑ "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochemical and Biophysical Research Communications 299 (4): 641–6. Dec 2002. doi:10.1016/s0006-291x(02)02698-0. PMID 12459187.
- ↑ "A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1". The Journal of Biological Chemistry 275 (27): 20806–13. Jul 2000. doi:10.1074/jbc.M000421200. PMID 10764742.
- ↑ "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Molecular and Cellular Biology 16 (1): 105–14. Jan 1996. doi:10.1128/mcb.16.1.105. PMID 8524286.
- ↑ "Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.". Cancer Research 68 (18): 7403–8. Sep 2008. doi:10.1158/0008-5472.CAN-08-1449. PMID 18794128.
- ↑ "Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis". Int. J. Oncol. 51 (5): 1370–1382. 2017. doi:10.3892/ijo.2017.4131. PMID 29048609.
- ↑ "Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors". Cell Adhes. Migr. 12 (5): 1–17. 2018. doi:10.1080/19336918.2018.1471323. PMID 29781749.
Further reading
- "Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms". Journal of Biochemistry 133 (1): 9–16. Jan 2003. doi:10.1093/jb/mvg018. PMID 12761193.
- "Protein kinase C iota: human oncogene, prognostic marker and therapeutic target". Pharmacological Research 55 (6): 487–97. Jun 2007. doi:10.1016/j.phrs.2007.04.015. PMID 17570678.
- "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx". Cellular Immunology 137 (1): 1–13. Oct 1991. doi:10.1016/0008-8749(91)90051-C. PMID 1832084.
- "The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway". Virology 176 (1): 126–32. May 1990. doi:10.1016/0042-6822(90)90237-L. PMID 1970444.
- "Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41". Journal of Immunology 144 (10): 3928–35. May 1990. doi:10.4049/jimmunol.144.10.3928. PMID 2139676. http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=2139676.
- "Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C". The EMBO Journal 9 (4): 1165–70. Apr 1990. doi:10.1002/j.1460-2075.1990.tb08223.x. PMID 2182321.
- "Human immunodeficiency virus induces phosphorylation of its cell surface receptor". Nature 333 (6170): 278–80. May 1988. doi:10.1038/333278a0. PMID 3259291. Bibcode: 1988Natur.333..278F.
- "HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells". The Journal of Biological Chemistry 270 (33): 19364–9. Aug 1995. doi:10.1074/jbc.270.33.19364. PMID 7642615.
- "Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein". Cancer Letters 88 (1): 37–40. Jan 1995. doi:10.1016/0304-3835(94)03610-U. PMID 7850771.
- "Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report". International Journal of Immunopharmacology 16 (3): 197–204. Mar 1994. doi:10.1016/0192-0561(94)90013-2. PMID 8206685.
- "Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells". The Journal of Biological Chemistry 268 (32): 24296–302. Nov 1993. doi:10.1016/S0021-9258(20)80525-0. PMID 8226978.
- "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Molecular and Cellular Biology 16 (1): 105–14. Jan 1996. doi:10.1128/MCB.16.1.105. PMID 8524286.
- "IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C". Cellular Immunology 168 (1): 100–6. Feb 1996. doi:10.1006/cimm.1996.0054. PMID 8599832.
- "Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes". Journal of Virology 70 (3): 1384–9. Mar 1996. doi:10.1128/JVI.70.3.1384-1389.1996. PMID 8627654.
- "The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C". Cell 86 (5): 777–86. Sep 1996. doi:10.1016/S0092-8674(00)80152-X. PMID 8797824.
- "In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46". Archives of Biochemistry and Biophysics 335 (1): 8–12. Nov 1996. doi:10.1006/abbi.1996.0476. PMID 8914829.
- "Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis". The Journal of Biological Chemistry 272 (44): 27521–4. Oct 1997. doi:10.1074/jbc.272.44.27521. PMID 9346882.
- "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochemical and Biophysical Research Communications 242 (2): 332–7. Jan 1998. doi:10.1006/bbrc.1997.7877. PMID 9446795.
- "Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62". Molecular and Cellular Biology 18 (5): 3069–80. May 1998. doi:10.1128/mcb.18.5.3069. PMID 9566925.
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