View source for Biology:FOXF1

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Forkhead box protein F1 (FOXF1)''' is a [[Biology:Protein|protein]] that in humans is encoded by the ''FOXF1'' [[Biology:Gene|gene]].<ref name="pmid8825632">{{cite journal | vauthors = Larsson C, Hellqvist M, Pierrou S, White I, Enerbäck S, Carlsson P | title = Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12) | journal = Genomics | volume = 30 | issue = 3 | pages = 464–9 | date = Dec 1995 | pmid = 8825632 | doi = 10.1006/geno.1995.1266 }}</ref><ref name="pmid7957066">{{cite journal | vauthors = Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P | title = Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending | journal = The EMBO Journal | volume = 13 | issue = 20 | pages = 5002–12 | date = Oct 1994 | pmid = 7957066 | pmc = 395442 | doi =  10.1002/j.1460-2075.1994.tb06827.x}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FOXF1 forkhead box F1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2294}}</ref>

== Function ==

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain.  FOX1 protein is important in the development of the pulmonary mesenchyme and the development of the [[Biology:Gastrointestinal tract|gastrointestinal tract]].<ref>{{Cite web|title=FOXF1 gene: MedlinePlus Genetics|url=https://medlineplus.gov/genetics/gene/foxf1/|access-date=2021-06-10|website=medlineplus.gov|language=en}}</ref>

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei MG, Schulz-Schaeffer W, Thies U | title = Human brain factor 1, a new member of the fork head gene family | journal = Genomics | volume = 21 | issue = 3 | pages = 551–7 | date = Jun 1994 | pmid = 7959731 | doi = 10.1006/geno.1994.1313 }}
* {{cite journal | vauthors = Hellqvist M, Mahlapuu M, Samuelsson L, Enerbäck S, Carlsson P | title = Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2 | journal = The Journal of Biological Chemistry | volume = 271 | issue = 8 | pages = 4482–90 | date = Feb 1996 | pmid = 8626802 | doi = 10.1074/jbc.271.8.4482 | doi-access = free }}
* {{cite journal | vauthors = Hellqvist M, Mahlapuu M, Blixt A, Enerbäck S, Carlsson P | title = The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB | journal = The Journal of Biological Chemistry | volume = 273 | issue = 36 | pages = 23335–43 | date = Sep 1998 | pmid = 9722567 | doi = 10.1074/jbc.273.36.23335 | doi-access = free }}
* {{cite journal | vauthors = Mahlapuu M, Pelto-Huikko M, Aitola M, Enerbäck S, Carlsson P | title = FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces | journal = Developmental Biology | volume = 202 | issue = 2 | pages = 183–95 | date = Oct 1998 | pmid = 9769171 | doi = 10.1006/dbio.1998.9010 | doi-access = free }}
* {{cite journal | vauthors = Coon DR, Roberts DJ, Loscertales M, Kradin R | title = Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia | journal = Experimental and Molecular Pathology | volume = 80 | issue = 2 | pages = 119–23 | date = Apr 2006 | pmid = 16448649 | doi = 10.1016/j.yexmp.2005.12.003 }}
* {{cite journal | vauthors = Lomenick JP, Hubert MA, Handwerger S | title = Transcription factor FOXF1 regulates growth hormone variant gene expression | journal = American Journal of Physiology. Endocrinology and Metabolism | volume = 291 | issue = 5 | pages = E947-51 | date = Nov 2006 | pmid = 16772323 | doi = 10.1152/ajpendo.00128.2006 }}
{{refend}}

== External links ==
* {{MeshName|FOXF1+protein,+human}}


{{NLM content}}
{{Transcription factors|g3}}
[[Category:Forkhead transcription factors]]

{{Sourceattribution|FOXF1}}