Biology:MDGA2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
| MAM domain containing glycosylphosphatidylinositol anchor 2 | |
|---|---|
| Identifiers | |
| Symbol | MDGA2 |
| Alt. symbols | MAMDC1 |
| NCBI gene | 161357 |
| HGNC | 19835 |
| OMIM | 611128 |
| RefSeq | NM_182830 |
| Other data | |
| Locus | Chr. 14 q21.2 |
MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is a human gene. It has previously been called MAMDC1.[1] MDGA2 is located on chromosome 14.
The gene has a homologue in rat and mouse, Mdga2,[2] and investigations in rats have found that the gene is expressed in the central and peripheral nervous system in a subpopulation of neurons, e.g., in the basilar pons and cerebral cortex.[3]
There are several variants in the human gene,[4] and a genome-wide association study has pointed to that single-nucleotide polymorphisms in MDGA2 is associated with neuroticism.[5] However, a more recent study has failed to replicate that finding.[6]
References
- ↑ "MDGA2 Gene — GeneCards". Weizmann Institute of Science. 2008-09-08. https://www.genecards.org/cgi-bin/carddisp.pl?gene=MDGA2.
- ↑ "Rat Genome Database: Mdga2 ( Rattus norvegicus )". Medical College of Wisconsin. http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=735131. Retrieved 2008-11-14.
- ↑ "Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization". Molecular and Cellular Neuroscience 25 (2): 263–264. February 2004. doi:10.1016/j.mcn.2003.10.016. PMID 15019943.
- ↑ "SNP linked to Gene MDGA2". NCBI. https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?locusId=161357.
- ↑ "18762592". Archives of General Psychiatry 65 (9): 1062–1071. September 2008. doi:10.1001/archpsyc.65.9.1062. PMID 18762592. http://archpsyc.ama-assn.org/cgi/content/full/65/9/1062.
- ↑ Hettema, John M.; Oord, Edwin J.C.G. van den; An, Seon-Sook; Kendler, Kenneth S.; Chen, Xiangning (2009). "Follow-up association study of novel neuroticism gene MAMDC1". Psychiatric Genetics 19 (4): 213–214. doi:10.1097/ypg.0b013e32832cec22. PMID 19440164. PMC 2844892. https://dx.doi.org/10.1097/ypg.0b013e32832cec22.
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