Biology:Sugar transporter SWEET1
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Sugar transporter SWEET1, also known as RAG1-activating protein 1 and stromal cell protein (SCP), is a membrane protein that in humans is encoded by the SLC50A1 gene.[1] SWEET1 is the sole transporter from the SLC50 (SWEET) gene family present in the genomes of most animal species, with the exception of the nematode Caenorhabditis elegans, which has seven.[2]
SWEET1 is a broadly-expressed glucose transporter.[2] As the SWEET family has been identified relatively recently, the full range of its functions in animals is not yet clear.[3] However, the bovine SLC50A1 homologue is associated with lactose concentration in milk,[4] and the CiRGA homologue in the sea squirt Ciona intestinalis is essential for tissue differentiation during embryogenesis, especially the development of the notochord.[5] SWEET genes are common in plant genomes, with around twenty paralogues [2] functioning as both sucrose and hexose transporters, and are also associated with pathogen susceptibility.[2][6]
References
- ↑ "Entrez Gene: Solute carrier family 50 (sugar efflux transporter), member 1". https://www.ncbi.nlm.nih.gov/gene/55974.
- ↑ 2.0 2.1 2.2 2.3 "Structure and function of SemiSWEET and SWEET sugar transporters". Trends in Biochemical Sciences 40 (8): 480–486. 2015. doi:10.1016/j.tibs.2015.05.005. PMID 26071195.
- ↑ "GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters". Protein Science 25 (3): 546–558. 2016. doi:10.1002/pro.2858. PMID 26650681.
- ↑ "DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content". BMC Genomics 18 (1): 968. 2017. doi:10.1186/s12864-017-4320-3. PMID 29246110.
- ↑ "Ci-Rga, a gene encoding an MtN3/saliva family transmembrane protein, is essential for tissue differentiation during embryogenesis of the ascidian Ciona intestinalis". Differentiation 73 (7): 364–376. 2005. doi:10.1111/j.1432-0436.2005.00037.x. PMID 16219040.
- ↑ "Glucose transport families SLC5 and SLC50". Molecular Aspects of Medicine 34 (2–3): 183–196. 2013. doi:10.1016/j.mam.2012.11.002. PMID 23506865.
Further reading
- "RGA protein associates with a TRPV ion channel during biosynthesis and trafficking". Journal of Cellular Biochemistry 91 (4): 808–20. Mar 2004. doi:10.1002/jcb.10775. PMID 14991772.
- "Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2". Annals of Neurology 71 (3): 370–84. Mar 2012. doi:10.1002/ana.22687. PMID 22451204.
- "Sugar transporters for intercellular exchange and nutrition of pathogens". Nature 468 (7323): 527–32. Nov 2010. doi:10.1038/nature09606. PMID 21107422. Bibcode: 2010Natur.468..527C.
- "Molecular cloning and characterization of a novel stromal cell-derived cDNA encoding a protein that facilitates gene activation of recombination activating gene (RAG)-1 in human lymphoid progenitors". Biochemical and Biophysical Research Communications 221 (3): 744–9. Apr 1996. doi:10.1006/bbrc.1996.0667. PMID 8630032.
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