Biology:TEL-JAK2
From HandWiki
Short description: Fusion gene
TEL-JAK2 is a gene fusion resulting from a chromosomal translocation between chromosomes 9 and 12 observed in human leukemia.[1][2] The 5' moiety of TEL is fused to the 3' end of JAK2.
The oligomerisation domain of the TEL protein (also called ETV6) becomes juxtaposed to the tyrosine kinase domain of JAK2, and as result the TEL-JAK2 displays constitutive kinase activity.
References
- ↑ "A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia". Science 278 (5341): 1309–12. 1997. doi:10.1126/science.278.5341.1309. PMID 9360930.
- ↑ "Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia". Blood 90 (7): 2535–40. 1997. doi:10.1182/blood.V90.7.2535. PMID 9326218.
External links
- TEL-JAK2+fusion+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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