Biology:Chromosome 9

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Short description: Human chromosome
Chromosome 9
Human male karyotpe high resolution - Chromosome 9 cropped.png
Human chromosome 9 pair after G-banding:
One is from the mother, one is from the father.
Human male karyotpe high resolution - Chromosome 9.png
Chromosome 9 pair
in human male karyogram
Features
Length (bp)150,617,247 bp
(CHM13)
No. of genes739 (CCDS)[1]
TypeAutosome
Centromere positionSubmetacentric[2]
(43.0 Mbp[3])
Complete gene lists
CCDSGene list
HGNCGene list
UniProtGene list
NCBIGene list
External map viewers
EnsemblChromosome 9
EntrezChromosome 9
NCBIChromosome 9
UCSCChromosome 9
Full DNA sequences
RefSeqNC_000009 (FASTA)
GenBankCM000671 (FASTA)

Chromosome 9 is one of the 23 pairs of chromosomes in humans. Humans normally have two copies of this chromosome, as they normally do with all chromosomes. Chromosome 9 spans about 150 million base pairs of nucleic acids (the building blocks of DNA) and represents between 4.0 and 4.5% of the total DNA in cells.

Genes

Number of genes

These are some of the gene count estimates of human chromosome 9. Because researchers use different approaches to genome annotation, their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.[4]

Estimated by Protein-coding genes Noncoding RNA genes Pseudogenes Source Release date
CCDS 739 — — [1] 2016-09-08
HGNC 749 246 590 [5] 2017-05-12
Ensembl 775 788 663 [6] 2017-03-29
UniProt 812 — — [7] 2018-02-28
NCBI 822 830 738 [8][9][10] 2017-05-19

Gene list

See also: Category:Genes on human chromosome 9.

The following is a partial list of genes on human chromosome 9. For a complete list, see the link in the infobox on the right.

The ABO gene, which determines ABO blood type, is located on the long arm of this chromosome. (Location: 9q34.2)


Diseases and disorders

The following diseases are some of those related to genes on chromosome 9:



Cytogenetic band

G-banding ideograms of human chromosome 9
G-banding ideogram of human chromosome 9 in resolution 850 bphs. Band length in this diagram is proportional to base-pair length. This type of ideogram is generally used in genome browsers (e.g. Ensembl, UCSC Genome Browser).
G-banding patterns of human chromosome 9 in three different resolutions (400,[11] 550[12] and 850[3]). Band length in this diagram is based on the ideograms from ISCN (2013).[13] This type of ideogram represents actual relative band length observed under a microscope at the different moments during the mitotic process.[14]
G-bands of human chromosome 9 in resolution 850 bphs[15]
Chr. Arm[16] Band[17] ISCN
start[18] 		ISCN
stop[18] 		Basepair
start 		Basepair
stop 		Stain[19] Density
9 p 24.3 0 127 1 2,200,000 gneg
9 p 24.2 127 268 2,200,001 4,600,000 gpos 25
9 p 24.1 268 451 4,600,001 9,000,000 gneg
9 p 23 451 677 9,000,001 14,200,000 gpos 75
9 p 22.3 677 846 14,200,001 16,600,000 gneg
9 p 22.2 846 987 16,600,001 18,500,000 gpos 25
9 p 22.1 987 1085 18,500,001 19,900,000 gneg
9 p 21.3 1085 1297 19,900,001 25,600,000 gpos 100
9 p 21.2 1297 1395 25,600,001 28,000,000 gneg
9 p 21.1 1395 1621 28,000,001 33,200,000 gpos 100
9 p 13.3 1621 1917 33,200,001 36,300,000 gneg
9 p 13.2 1917 2030 36,300,001 37,900,000 gpos 25
9 p 13.1 2030 2171 37,900,001 39,000,000 gneg
9 p 12 2171 2312 39,000,001 40,000,000 gpos 50
9 p 11.2 2312 2523 40,000,001 42,200,000 gneg
9 p 11.1 2523 2650 42,200,001 43,000,000 acen
9 q 11 2650 2876 43,000,001 45,500,000 acen
9 q 12 2876 3468 45,500,001 61,500,000 gvar
9 q 13 3468 3609 61,500,001 65,000,000 gneg
9 q 21.11 3609 3792 65,000,001 69,300,000 gpos 25
9 q 21.12 3792 3876 69,300,001 71,300,000 gneg
9 q 21.13 3876 4060 71,300,001 76,600,000 gpos 50
9 q 21.2 4060 4229 76,600,001 78,500,000 gneg
9 q 21.31 4229 4440 78,500,001 81,500,000 gpos 50
9 q 21.32 4440 4638 81,500,001 84,300,000 gneg
9 q 21.33 4638 4835 84,300,001 87,800,000 gpos 50
9 q 22.1 4835 5074 87,800,001 89,200,000 gneg
9 q 22.2 5074 5173 89,200,001 91,200,000 gpos 25
9 q 22.31 5173 5314 91,200,001 93,900,000 gneg
9 q 22.32 5314 5455 93,900,001 96,500,000 gpos 25
9 q 22.33 5455 5638 96,500,001 99,800,000 gneg
9 q 31.1 5638 5892 99,800,001 105,400,000 gpos 100
9 q 31.2 5892 6005 105,400,001 108,500,000 gneg
9 q 31.3 6005 6146 108,500,001 112,100,000 gpos 25
9 q 32 6146 6456 112,100,001 114,900,000 gneg
9 q 33.1 6456 6681 114,900,001 119,800,000 gpos 75
9 q 33.2 6681 6822 119,800,001 123,100,000 gneg
9 q 33.3 6822 6949 123,100,001 127,500,000 gpos 25
9 q 34.11 6949 7217 127,500,001 130,600,000 gneg
9 q 34.12 7217 7302 130,600,001 131,100,000 gpos 25
9 q 34.13 7302 7443 131,100,001 133,100,000 gneg
9 q 34.2 7443 7555 133,100,001 134,500,000 gpos 25
9 q 34.3 7555 7950 134,500,001 138,394,717 gneg

References

  1. ↑ 1.0 1.1 "Search results - 1[CHR] AND "Homo sapiens"[Organism] AND ("has ccds"[Properties] AND alive[prop]) - Gene". 2016-09-08. https://www.ncbi.nlm.nih.gov/gene?term=1%5BChr%5D%20AND%20%22Homo%20sapiens%22%5BOrganism%5D%20AND%20%28%22has%20ccds%22%5BProperties%5D%20AND%20alive%5Bprop%5D%29&cmd=DetailsSearch. 
  2. ↑ Tom Strachan; Andrew Read (2 April 2010). Human Molecular Genetics. Garland Science. p. 45. ISBN 978-1-136-84407-2. https://books.google.com/books?id=dSwWBAAAQBAJ&pg=PA45. 
  3. ↑ 3.0 3.1 Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
  4. ↑ Pertea M, Salzberg SL (2010). "Between a chicken and a grape: estimating the number of human genes.". Genome Biol 11 (5): 206. doi:10.1186/gb-2010-11-5-206. PMID 20441615. 
  5. ↑ "Statistics & Downloads for chromosome 9". 2017-05-12. https://www.genenames.org/cgi-bin/statistics?c=9. 
  6. ↑ "Chromosome 9: Chromosome summary - Homo sapiens". 2017-03-29. http://mar2017.archive.ensembl.org/Homo_sapiens/Location/Chromosome?r=9. 
  7. ↑ "Human chromosome 9: entries, gene names and cross-references to MIM". 2018-02-28. https://www.uniprot.org/docs/humchr09.txt. 
  8. ↑ "Search results - 9[CHR] AND "Homo sapiens"[Organism] AND ("genetype protein coding"[Properties] AND alive[prop]) - Gene". 2017-05-19. https://www.ncbi.nlm.nih.gov/gene?term=9%5BCHR%5D%20AND%20%22Homo%20sapiens%22%5BOrganism%5D%20AND%20%28%22genetype%20protein%20coding%22%5BProperties%5D%20AND%20alive%5Bprop%5D%29&cmd=DetailsSearch. 
  9. ↑ "Search results - 9[CHR] AND "Homo sapiens"[Organism] AND ( ("genetype miscrna"[Properties] OR "genetype ncrna"[Properties] OR "genetype rrna"[Properties] OR "genetype trna"[Properties] OR "genetype scrna"[Properties] OR "genetype snrna"[Properties] OR "genetype snorna"[Properties]) NOT "genetype protein coding"[Properties] AND alive[prop]) - Gene". 2017-05-19. https://www.ncbi.nlm.nih.gov/gene?term=9%5BCHR%5D%20AND%20%22Homo%20sapiens%22%5BOrganism%5D%20AND%20%28%28%22genetype%20miscrna%22%5BProperties%5D%20OR%20%22genetype%20ncrna%22%5BProperties%5D%20OR%20%22genetype%20rrna%22%5BProperties%5D%20OR%20%22genetype%20trna%22%5BProperties%5D%20OR%20%22genetype%20scrna%22%5BProperties%5D%20OR%20%22genetype%20snrna%22%5BProperties%5D%20OR%20%22genetype%20snorna%22%5BProperties%5D%29%20NOT%20%22genetype%20protein%20coding%22%5BProperties%5D%20AND%20alive%5Bprop%5D%29&cmd=DetailsSearch. 
  10. ↑ "Search results - 9[CHR] AND "Homo sapiens"[Organism] AND ("genetype pseudo"[Properties] AND alive[prop]) - Gene". 2017-05-19. https://www.ncbi.nlm.nih.gov/gene?term=9%5BCHR%5D%20AND%20%22Homo%20sapiens%22%5BOrganism%5D%20AND%20%28%22genetype%20pseudo%22%5BProperties%5D%20AND%20alive%5Bprop%5D%29&cmd=DetailsSearch. 
  11. ↑ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (400 bphs, Assembly GRCh38.p3). Last update 2014-03-04. Retrieved 2017-04-26.
  12. ↑ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (550 bphs, Assembly GRCh38.p3). Last update 2015-08-11. Retrieved 2017-04-26.
  13. ↑ International Standing Committee on Human Cytogenetic Nomenclature (2013). ISCN 2013: An International System for Human Cytogenetic Nomenclature (2013). Karger Medical and Scientific Publishers. ISBN 978-3-318-02253-7. https://books.google.com/books?id=lGCLrh0DIwEC. 
  14. ↑ Sethakulvichai, W.; Manitpornsut, S.; Wiboonrat, M.; Lilakiatsakun, W.; Assawamakin, A.; Tongsima, S. (2012). "Estimation of band level resolutions of human chromosome images". 2012 Ninth International Conference on Computer Science and Software Engineering (JCSSE). pp. 276–282. doi:10.1109/JCSSE.2012.6261965. ISBN 978-1-4673-1921-8. https://www.researchgate.net/publication/261304470. 
  15. ↑ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
  16. ↑ "p": Short arm; "q": Long arm.
  17. ↑ For cytogenetic banding nomenclature, see article locus.
  18. ↑ 18.0 18.1 These values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit.
  19. ↑ gpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk.

External links



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