Chemistry:5'-Guanylyl imidodiphosphate
From HandWiki
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| Names | |
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| IUPAC name
Guanosine 5′-(tetrahydrogen 4-imidotriphosphate)
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| Systematic IUPAC name
O5-{[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl} tetrahydrogen 2-imidotriphosphate | |
| Other names
GppNHp; GppNP; GMP-Pnp; GDP-NP
Guanylyl imidodiphosphate 5-Guanylylimidodiphosphate 5′-Guanylyliminodiphosphonate | |
| Identifiers | |
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3D model (JSmol)
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PubChem CID
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| Properties | |
| C10H17N6O13P3 | |
| Molar mass | 522.196 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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| Infobox references | |
Tracking categories (test):
5'-Guanylyl imidodiphosphate (GDPNP) is a purine nucleotide. It is an analog of guanosine triphosphate in which one of the oxygen atoms is replaced with an amine, producing a non-hydrolyzable functional group. Guanylyl imidodiphosphate binds tightly to G-proteins in the presence of Mg2+.[2] Guanylyl imidodiphosphate is a potent stimulator of adenylate cyclase.[2] It is often used in studies of protein synthesis.[3][4]
References
- ↑ Guanosine 5′-β,γ-imidotriphosphate trisodium salt hydrate at Sigma-Aldrich
- ↑ 2.0 2.1 Guanylyl imidodiphosphate at PubChem
- ↑ Miller, J.D.; Walter, P. (1993). "A GTPase Cycle in Initiation of Protein Translocation Across the Endoplasmic Reticulum Membrane". Ciba Foundation Symposium 176 - the GTPase Superfamily. Novartis Foundation Symposia. 176. 147–163. doi:10.1002/9780470514450.ch10. ISBN 9780470514450.
- ↑ Connolly, T. (1991). "Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor". Science 252 (5009): 1171–1173. doi:10.1126/science.252.5009.1171. PMID 1851576. Bibcode: 1991Sci...252.1171C.
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