Chemistry:AM-2-19

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AM-2-19 is an experimental antifungal drug based on amphotericin B (AmB) that is engineered to be less toxic to the kidneys.[1][2][3]

References

  1. ↑ "New antifungal kills without toxic side effects". https://www.science.org/content/article/new-antifungal-kills-without-toxic-side-effects. 
  2. ↑ Maji, Arun; Soutar, Corinne P.; Zhang, Jiabao; Lewandowska, Agnieszka; Uno, Brice E.; Yan, Su; Shelke, Yogesh; Murhade, Ganesh et al. (8 November 2023). "Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal" (in en). Nature 623 (7989): 1079–1085. doi:10.1038/s41586-023-06710-4. ISSN 1476-4687. PMID 37938782. Bibcode: 2023Natur.623.1079M. https://www.nature.com/articles/s41586-023-06710-4. 
  3. ↑ "Antifungal analog offers reduced toxicity" (in en). Chemical & Engineering News. https://cen.acs.org/biological-chemistry/Antifungal-analog-offers-reduced-toxicity/101/web/2023/11. 



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