Chemistry:Nizofenone
From HandWiki
Short description: Chemical compound
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| Formula | C21H21ClN4O3 |
| Molar mass | 412.87 g·mol−1 |
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Nizofenone (Ekonal, Midafenone) is a neuroprotective drug which protects neurons from death following cerebral anoxia (interruption of oxygen supply to the brain). It might thus be useful in the treatment of acute neurological conditions such as stroke.[1][2][3][4]
References
- ↑ "Nizofenone administration in the acute stage following subarachnoid hemorrhage. Results of a multi-center controlled double-blind clinical study". Journal of Neurosurgery 64 (3): 420–426. March 1986. doi:10.3171/jns.1986.64.3.0420. PMID 3512795.
- ↑ "Brain Protection Against Oxygen Deficiency by Nizofenone". Oxygen Transport to Tissue X. Advances in Experimental Medicine and Biology. 222. 1988. pp. 403–10. doi:10.1007/978-1-4615-9510-6_48. ISBN 978-1-4615-9512-0.
- ↑ "Brain protection against ischemic injury by nizofenone". Cerebrovascular and Brain Metabolism Reviews 5 (4): 264–276. 1993. PMID 8110594.
- ↑ "Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation". European Journal of Pharmacology 262 (1–2): 157–161. September 1994. doi:10.1016/0014-2999(94)90039-6. PMID 7813567.
Further reading
- "Prevention of neurodegeneration by a neuroprotective radical scavenger". Annals of the New York Academy of Sciences 893 (1): 430–433. 1999. doi:10.1111/j.1749-6632.1999.tb07871.x. PMID 10672283. Bibcode: 1999NYASA.893..430Y.
- "Effect of nizofenone on experimental head trauma in mice". Archives Internationales de Pharmacodynamie et de Therapie 328 (3): 251–260. 1994. PMID 7625881.
- "Biphasic liberation of arachidonic and stearic acids during cerebral ischemia". Journal of Neurochemistry 45 (1): 168–172. July 1985. doi:10.1111/j.1471-4159.1985.tb05489.x. PMID 2987409.
- "Stimulation of prostacyclin synthesis by nizofenone". Biochemical Pharmacology 33 (17): 2707–2709. September 1984. doi:10.1016/0006-2952(84)90684-1. PMID 6431991.
- "A double-blind clinical evaluation of the effect of Nizofenone (Y-9179) on delayed ischemic neurological deficits following aneurysmal rupture". Neurological Research 5 (4): 29–47. 1983. doi:10.1080/01616412.1983.11739654. PMID 6149485.
- "Mechanisms of cerebral protection by pentobarbital and nizofenone correlated with the course of local cerebral blood flow changes". Stroke 13 (6): 788–796. 1982. doi:10.1161/01.str.13.6.788. PMID 7147293.
- "Cerebral protective effect and radical scavenging action". Journal of Neurochemistry 37 (4): 934–938. October 1981. doi:10.1111/j.1471-4159.1981.tb04480.x. PMID 7320731.
- "The mechanism of action of a novel cerebral protective drug against anoxia I. The effect on cerebral energy demand". Archives Internationales de Pharmacodynamie et de Therapie 242 (1): 77–85. November 1979. PMID 543750.
- "Protection from cerebral ischemia by a new imidazole derivative (Y-9179) and pentobarbital. A comparative study in chronic middle cerebral artery occlusion in cats". Stroke 10 (2): 126–134. 1979. doi:10.1161/01.str.10.2.126. PMID 442136.
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