Biography:Akhilesh Reddy
Akhilesh Reddy | |
|---|---|
| Alma mater | University of Cambridge |
| Scientific career | |
| Fields | Neuroscience Chronobiology Genetics Pharmacology |
| Institutions | Francis Crick Institute MRC Laboratory of Molecular Biology |
Akhilesh Reddy is a British physician-scientist. He is a professor of Systems Pharmacology and Translational Therapeutics at the University of Pennsylvania,[1] and was previously a Wellcome Trust Senior Fellow in Clinical Sciences at the University of Cambridge and Fellow of St John's College, Cambridge.
Early life and education
Reddy is of Indian origin.[2] He completed the MB/PhD program at the University of Cambridge where he received a PhD from the MRC Laboratory of Molecular Biology.[3]
Research
In 2011, Reddy's research group demonstrated the existence of circadian clocks within human red blood cells (erythrocytes).[4] Since human red blood cells lack a nucleus, and therefore DNA, the circadian clock posited by Reddy's group did not rely on the transcription and translation of DNA as its basis. The circadian clock observed in red blood cells could be interpreted as a form of biochemical or chemical clock, extending over a prolonged 24-hour timeframe.[5] Sir Christopher Dobson, a British Chemist, drew parallels between this red blood cell clock, and established short-period oscillations in chemical systems.[5]
In collaboration with the research team led by Andrew Millar in Edinburgh, Reddy's group demonstrating 24-hour oscillations that manifest in marine algae without necessitating RNA production.[6] This demonstrated circadian rhythms in higher organisms that did not require the involvement of new RNA formation.
In 2012, Reddy's research group demonstrated that redox circadian oscillations are universally present across evolutionary epochs, spanning from bacteria to humans. To show this, they used peroxiredoxin proteins, a novel molecular perspective into circadian dynamics.[7] Michael Rosbash stated this finding challenged conventional animal models that emphasized PER-CLK transcription. Rosbash underscored the emerging consideration of metabolism and peroxiredoxin hyperoxidation in the orchestration of circadian rhythms.[8]
In 2018, Reddy's team showed the link between core glucose metabolism and circadian transcriptional oscillations, as well as non-canonical circadian rhythms in clock-less fruit fly cells.[9] These findings show that there continues to be an incomplete understanding of molecular circadian rhythms in a range of organisms.[10]
Controversy
In December 2019, Reddy underwent a hearing at the Medical Practitioners Tribunal regarding alleged overpayment by both University College of London and the University of Cambridge.[11] After unsuccessfully appealing this decision at the High Court, Reddy was suspended for nine months from the medical practice in the United Kingdom. [12]
Prizes and awards
- 2011: EMBO Young Investigator Award.[13]
- 2012: Lister Prize.[14]
- 2012: Colworth Medal.[15][16][17]
- 2013: Academy of Medical Sciences Foulkes Foundation Medal.[18][19]
- 2014: Elected to American Society for Clinical Investigation (ASCI).[13]
- 2014: FEBS Anniversary Prize.[20]
- 2015: Linacre Medal and Lecture (Royal College of Physicians).[21]
References
- ↑ "Akhilesh B. Reddy, MA MB BChir PhD FRCP". University of Pennsylvania. https://www.med.upenn.edu/apps/faculty/index.php/g275/p9140206.
- ↑ "Indian-origin professor faces inquiry over drawing double salaries in UK". Business Standard. 20 April 2019. https://www.business-standard.com/article/pti-stories/indian-origin-professor-faces-inquiry-over-drawing-double-salaries-in-uk-119042000347_1.html.
- ↑ "Dr Akhilesh Reddy Bio at the Lister Institute". http://www.lister-institute.org.uk/dr-akhilesh-reddy/.
- ↑ O'Neill, John S.; Reddy, Akhilesh B. (26 January 2011). "Circadian clocks in human red blood cells". Nature 469 (7331): 498–503. doi:10.1038/nature09702. PMID 21270888. Bibcode: 2011Natur.469..498O.
- ↑ 5.0 5.1 Dobson, Christopher M. (2014). "Dynamics and Timekeeping in Biological Systems". Annual Review of Biochemistry 83 (1): 159–164. doi:10.1146/annurev-biochem-013014-102724. PMID 24606145.
- ↑ O'Neill, John S.; van Ooijen, Gerben; Dixon, Laura E.; Troein, Carl; Corellou, Florence; Bouget, François-Yves; Reddy, Akhilesh B.; Millar, Andrew J. (26 January 2011). "Circadian rhythms persist without transcription in a eukaryote". Nature 469 (7331): 554–558. doi:10.1038/nature09654. PMID 21270895. Bibcode: 2011Natur.469..554O.
- ↑ Rachel S. Edgar; Edward W. Green; Yuwei Zhao; Gerben van Ooijen; Maria Olmedo; Ximing Qin; Yao Xu; Min Pan et al. (16 May 2012). "Peroxiredoxins are conserved markers of circadian rhythms". Nature 485 (7399): 459–464. doi:10.1038/nature11088. PMID 22622569. Bibcode: 2012Natur.485..459E.
- ↑ Rosbash, Michael (2017-06-09). "A 50-Year Personal Journey: Location, Gene Expression, and Circadian Rhythms" (in en). Cold Spring Harbor Perspectives in Biology 9 (12). doi:10.1101/cshperspect.a032516. ISSN 1943-0264. PMID 28600396.
- ↑ Rey, Guillaume; Milev, Nikolay B; Valekunja, Utham K; Ch, Ratnasekhar; Ray, Sandipan; Silva Dos Santos, Mariana; Nagy, Andras D; Antrobus, Robin et al. (2018-08-01). "Metabolic oscillations on the circadian time scale in Drosophila cells lacking clock genes". Molecular Systems Biology 14 (8). doi:10.15252/msb.20188376. ISSN 1744-4292. PMID 30072421.
- ↑ Ode, Koji L; Ueda, Hiroki R (2018-09-24). "Lost in clocks: non-canonical circadian oscillation discovered in Drosophila cells". Molecular Systems Biology 14 (9). doi:10.15252/msb.20188567. ISSN 1744-4292. PMID 30249605.
- ↑ "Cambridge and UCL professor 'did not notice' double salaries". BBC News. 2019-12-31. https://www.bbc.co.uk/news/uk-england-cambridgeshire-50956380.
- ↑ "Reddy v General Medical Council, [2021 EWHC 435 (Admin) | England and Wales High Court (Administrative Court), Judgment, Law, casemine.com"] (in en). https://www.casemine.com/judgement/uk/6041d4642c94e06a9be7b954.
- ↑ 13.0 13.1 "ASCI - The American Society for Clinical Investigation". http://www.the-asci.org/core/controllers/asci/AsciProfileController.php?pid=501091.
- ↑ "2012 Lister Prize for Ak Reddy". Wellcome-MRC Institute of Metabolic Science. 2012-05-10. https://www.mrl.ims.cam.ac.uk/blog/2012-lister-prize-for-ak-reddy/.
- ↑ Looi, Mun-Keat. "Colworth Medal for Trust Fellow". http://blog.wellcome.ac.uk/2011/03/03/colworth-medal-for-trust-fellow/.
- ↑ "Dr Akhilesh Reddy awarded Colworth Medal". http://www.joh.cam.ac.uk/dr-akhilesh-reddy-awarded-colworth-medal.
- ↑ "The Colworth Medal". http://www.biochemistry.org/awards/thecolworthmedal.aspx.
- ↑ "Foulkes Foundation Medal " The Foulkes Foundation". http://www.foulkes-foundation.org/category/foulkes-medal/.
- ↑ "Foulkes Foundation Medal | Academy of Medical Sciences". http://www.acmedsci.ac.uk/about/objectives/promoting-excellence/foulkes-foundation-medal/.
- ↑ "FEBS Anniversary Prize der GBM – Homepage der Gesellschaft für Biochemie und Molekularbiologie e.V." (in de). https://www.gbm-online.de/preise-und-auszeichnungen-details/febs-anniversary-prize-der-gbm.html.
- ↑ "Biography | The Francis Crick Institute". The Francis Crick Institute. https://www.crick.ac.uk/research/a-z-researchers/researchers-p-s/akhilesh-b-reddy/biography/.
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