Biography:D. Lansing Taylor

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Short description: American biologist
D. Lansing (Lans) Taylor
Alma mater
Awards
  • Received Society for Biomolecular Sciences (SBS) Accomplishment Award (2007)[1]
Scientific career
InstitutionsUniversity of Pittsburgh
Website

D. Lansing Taylor is the Director at the University of Pittsburgh Drug Discovery Institute (UPDDI), Pennsylvania and a faculty member in the Department of Computational and Systems Biology.[2]

Early life and education

Lansing Taylor was born in Baltimore, Maryland. He received his B.S. in zoology from the University of Maryland,[3] followed by his Ph.D. in the field of cell biology from the State University of New York at Albany.[4] He spent a postdoctoral fellowship at the Woods Hole Marine Biological Laboratories (MBL) in the field of cellular biophysics.[5]

Research and career

Lansing Taylor originally did research on the cellular and molecular mechanisms of Amoeboid movements at Harvard University as an assistant and associate professor.[6] He moved to Carnegie Mellon University (CMU) as a professor to direct the Center for Fluorescence Research where he led the program to develop fluorescence-based biosensors of cellular physiology and light microscope imaging systems for various applications in basic biomedical research.[7][8] During this time he co-founded Biological Detection Systems to commercialize fluorescence-based reagents and research imaging platforms, later purchased by Amersham, now GE Life Sciences. Lans left CMU to found Cellomics and created High Content Screening (HCS) for large-scale phenotypic screening for drug discovery and development which later became part of ThermoFisher.[9] Cellumen was the next company founded by Lans to apply systems cell biology to both drug safety testing (now part of Cyprotex) and cancer diagnostics.[10][11][12][13] The cancer diagnostics unit was spun off as Cernostics and they created a test for Barrett’s Esophagus. He returned to academia as the Director of the UPDDI. His current research interests include the development and application of human microphysiology systems as more advanced experimental models for drug discovery and development, the application of quantitative systems pharmacology (QSP) for a new paradigm in drug discovery and computational and systems pathology to predict therapeutic strategies for a variety of diseases.[14] He is the co-founder and Chairman of SpIntellx, a computational and systems pathology company with focus on spatial analytics and explainable AI (xAI).[15]

Awards and honors

D. Lansing Taylor received the Society for Biomolecular Sciences (SBS) Accomplishment Award for the development of High-Content Screening (HCS).[16][17] His additional awards include the Smithsonian Award for developing live cell imaging technologies and the Mack Fulwyler Award from the International Society for Advancement of Cytometry (ISAC) for outstanding contributions to the field of cytometry.[18] Lans is a Fellow of the American Institute for Medical and Biomedical Engineering.[19] Honors include receiving the National Science Foundation Pioneer Award for recognition of the vision, leadership and entrepreneurial spirit for the Science and Technology Centers and the Ernst & Young Entrepreneur of the Year in Pennsylvania for Cellomics.[20]

Grants

  • D. Lansing Taylor research on Human Microphysiology Systems Disease Model of Type 2 Diabetes Starting with Liver and pancreatic Islets was funded by the National Institute of Health (NIH) agency and the project started on 20 September 2018 and it will end on 31 July 2023.[21]
  • D. Lansing Taylor research on Harnessing human brain and liver microphysiological systems for testing therapeutics for metastatic melanoma was funded by the National Institute of Health (NIH) agency and the project started on 1 August 2018 and it will end on 31 July 2023.[22]
  • D. Lansing Taylor research on Applying a Human Liver Microphysiology System to Develop Therapeutic Strategies for Non-Alcoholic Fatty Liver Disease (NAFLD) was funded by the National Institute of Health (NIH) agency and the project started on 1 August 2018 and it will end on 30 April 2022.[23]

Patents

D. Lansing Taylor obtained >29 patents for his inventions. His patents include Standing Wave Luminescence microscopy (US4621911A),[24] Field synthesis and optical subsectioning for standing wave microscopy (US-6055097-A),[25] System for Cell-based screening (US5989835A),[26] Miniaturized cell array methods and apparatus for cell-based screening (US-6103479-A),[27] and Method for automated tissue analysis (US8114615B2).[28]

References

  1. ↑ "Lansing". https://cen.acs.org/articles/85/i6/D-Lansing-Taylor-Receives-2007.html. 
  2. ↑ "D. Lansing Taylor | Computational & Systems Biology" (in en-US). https://www.csb.pitt.edu/people/faculty/d-lansing-taylor/. 
  3. ↑ "Drug Discovery Institute - D. Lansing Taylor" (in en-US). https://www.upddi.pitt.edu/index.php?page=taylor. 
  4. ↑ "D. Lansing Taylor | Computational & Systems Biology" (in en-US). https://www.csb.pitt.edu/people/faculty/d-lansing-taylor/. 
  5. ↑ Taylor, D. L. (2003-08-01). "An Interview with D. Lansing Taylor, Ph.D., Chief Executive Officer, Cellomics, Inc.". ASSAY and Drug Development Technologies 1 (4): 501–505. doi:10.1089/154065803322302754. ISSN 1540-658X. PMID 15090246. 
  6. ↑ Taylor, D. Lansing; Condeelis, Johns S. (1979-01-01), Bourne, G. H.; Danielli, J. F., eds., Cytoplasmic Structure and Contractility in Amoeboid Cells, International Review of Cytology, 56, Academic Press, pp. 57–144, doi:10.1016/s0074-7696(08)61821-5, ISBN 9780123643568, PMID 37189, https://archive.org/details/internationalrev0000unse_j7a3/page/57 
  7. ↑ "Faculty List" (in en-US). http://www.compbio.cmu.edu/faculty-list/. 
  8. ↑ "Fluorescence Microscopy of Living Cells in Culture, Part A, Volume 29 - 1st Edition". https://www.elsevier.com/books/fluorescence-microscopy-of-living-cells-in-culture-part-a/wang/978-0-12-564129-6. 
  9. ↑ Taylor, D. Lansing, ed (2006) (in en). High Content Screening. Methods in Molecular Biology. Humana Press. ISBN 9781588297310. https://archive.org/details/highcontentscree00dlan. 
  10. ↑ "Cellumen Spins Off Personalized Medicine Unit as Cernostics Pathology, Inc." (in en). 2008-07-16. https://www.businesswire.com/news/home/20080716006303/en/Cellumen-Spins-Personalized-Medicine-Unit-Cernostics-Pathology. 
  11. ↑ "Cellumen to Collaborate with the NCTR of the FDA to Apply Cellular Systems Biology to Predictive Toxicology" (in en). https://www.technologynetworks.com/drug-discovery/news/cellumen-to-collaborate-with-the-nctr-of-the-fda-to-apply-cellular-systems-biology-to-predictive-toxicology-190192. 
  12. ↑ "Cellumen Inc." (in en). https://bciq.biocentury.com/companies/cellumen_inc. 
  13. ↑ "Cellumen Creates New Firm from Its Personalized Medicine Unit" (in en-US). 2008-07-17. https://www.genengnews.com/news/cellumen-creates-new-firm-from-its-personalized-medicine-unit/. 
  14. ↑ "QuantitativeSystemsPharmacologyandtheBridgefrominvitrotoinvivoToxicologyandDiseaseModeling". http://nas-sites.org/ilar-roundtable/files/2017/10/TAYLOR-NAS-10-6-17-Final-1.pdf. 
  15. ↑ "SpIntellx". https://www.spintellx.com/. 
  16. ↑ "D. Lansing Taylor Receives 2007 SBS Accomplishment Award | Chemical & Engineering News". https://cen.acs.org/articles/85/i6/D-Lansing-Taylor-Receives-2007.html?type=paidArticleContent. 
  17. ↑ SelectScience. "D. Lansing Taylor Receives the 2007 SBS Accomplishment Award | SelectScience". http://www.selectscience.net/industry-news/d-lansing-taylor-receives-the-2007-sbs-accomplishment-award/?artID=10708. 
  18. ↑ "About" (in en-US). 2015-02-18. https://pathways.mbic.cmu.edu/about/. 
  19. ↑ "D. Lansing Taylor, Ph.D. COF-0987 - AIMBE" (in en). https://aimbe.org/college-of-fellows/cof-0987/. 
  20. ↑ "Advances and New Approaches in Imaging Technology: Expanding the Reach of High-Content Analysis" (in en). 2017-01-25. https://www.sciencemag.org/custom-publishing/webinars/advances-and-new-approaches-imaging-technology-expanding-reach-high. 
  21. ↑ Taylor, D.. "Human Microphysiology Systems Disease Model of Type 2 Diabetes Starting with Liver and pancreatic Islets" (in en). https://grantome.com/grant/NIH/UG3-DK119973-01. 
  22. ↑ Murphy, William; Taylor, D.; Wikswo, John. "Harnessing human brain and liver microphysiological systems for testing therapeutics for metastatic melanoma" (in en). https://grantome.com/grant/NIH/U01-TR002383-01. 
  23. ↑ Taylor, D.. "Applying a Human Liver Microphysiology System to Develop Therapeutic Strategies for Non-Alcoholic Fatty Liver Disease (NAFLD)" (in en). https://grantome.com/grant/NIH/R01-DK117881-01. 
  24. ↑ "Standing wave luminescence microscopy" patent, issued 1985-03-12
  25. ↑ "Field synthesis and optical subsectioning for standing wave microscopy" patent, issued 1998-04-08
  26. ↑ "System for cell-based screening" patent, issued 1997-02-27
  27. ↑ "Miniaturized cell array methods and apparatus for cell-based screening" patent, issued 1997-05-29
  28. ↑ "Method for automated tissue analysis" patent, issued 2007-05-17




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