Biography:Edna Cukierman
Eti Cukierman | |
---|---|
![]() Cukierman in a Congressionally Directed Medical Research Programs (CDMRP) photo, 2018 | |
Born | Edna Cukierman |
Alma mater | Technion – Israel Institute of Technology |
Scientific career | |
Fields | Tumor microenvironment Cancer associated fibroblasts Extracellular matrix Pancreatic cancer Desmoplasia[1] |
Institutions | National Institute of Dental and Craniofacial Research Fox Chase Cancer Center |
Thesis | Molecular characterization of an ARF directed GTPase activating protein (1997) |
Doctoral students | Jaye Gardiner |
Website | {{{1}}} |
Edna "Eti" Cukierman is a Mexican biochemist who is a professor at the Fox Chase Cancer Center.[1][2] She serves as co-director of the Marvin & Concetta Greenberg Pancreatic Cancer Institute. Her research investigates pancreatic cancer and the tumor microenvironment.
Early life and education
Cukierman was born in Mexico City.[3] She emigrated to Israel in 1986.[3] She joined Technion – Israel Institute of Technology for her doctoral research, where she studied ARF directed GTPase.[4][5]
Research and career
After her PhD, Cukierman was awarded a postdoctoral fellowship in 1997, and joined the National Institute of Dental and Craniofacial Research.[3] She developed a multilayered fibroblastic cell-derived extracellular matrix, which became widely used in biomaterials research.[6][7]
Cukierman joined the Fox Chase Cancer Center in 2002.[3] She studies pancreatic cancer, with a specific focus on the tumor microenvironment and the identification of strategies that can change the tumor microenvironment.[8] Desmoplasia, which is the growth of connective tissue, shows similarities to wound healing pathologies (e.g. chronic inflammation).[9][10] She believes it will be possible to stall the growth of tumors by transforming the microenvironment into one which harnesses anti-tumor functions.[11]
In 2005, Cukierman demonstrated that desmoplastic extracellular matrices could induce a myofibroblastic phenotype on naïve fibroblastic cells.[12] This work involved the realization of a human mimetic three-dimensional stroma system, which allowed Cukierman to understand the extracellular factors that determine the function of fibroblasts.[12] Through multi-cellular culturing, Cukierman has shown how cancer-associated fibroblasts impart immunosuppressive influences, communicate and provide nutrition to cancer cells.[12] She identified that cancer communication involved the TGF beta signaling pathway, extracellular matrix and integrin signalling pathway and the reorganization of cytoskeletal elements.[13] She demonstrated that the glutamatergic presynaptic protein Netrin G1 promoted tumorgenesis by providing nutritional support and immunity to cancer-associated fibroblasts.[14] She has shown that anti-Netrin G1 antibodies can halt tumorgenesis.[9]
Cukierman joined the American Gastroenterological Association in 2010.[8] At the time, this was considered novel because the association is mainly a medical association, and Cukierman is not a physician.[8] In 2017, she established the Marvin and Concetta Greenberg Pancreatic Cancer Institute.[15]
Awards and honors
- 2004 AACR-Pennsylvania Department of Health Career Development Award[6]
- 2005 Nikon Small World Competition Image of Distinction[16][17]
- 2015 United States Department of Defense Idea Award[9]
- 2016 Chinese Society of Clinical Oncology Distinguished Achievement Award[9]
- 2020 Elected to the Council of the American Society of Matrix Biology[3][18]
- 2020 Worldwide Cancer Research Award[11]
- 2020 Elected Fellow of the American Gastroenterological Association[8]
Academic service
Cukierman has supported the development of early career researchers, and has developed a philosophy around teaching and mentoring. She is a member of the American Cancer Society, and on the editorial board of Matrix Biology.[19]
Selected publications
- Taking cell-matrix adhesions to the third dimension[20]
- Modeling tissue morphogenesis and cancer in 3D[21]
- A framework for advancing our understanding of cancer-associated fibroblasts[22]
References
- ↑ 1.0 1.1 {{Google Scholar id}} template missing ID and not present in Wikidata.
- ↑ Edna Cukierman publications from Europe PubMed Central
- ↑ 3.0 3.1 3.2 3.3 3.4 "Edna Cukierman Elected to Council of the American Society for Matrix Biology" (in en). 2020-01-07. https://www.foxchase.org/news/2020-01-23-edna-cukierman-elected-council-american-society-matrix-biology.
- ↑ "איפיון וניקוי של חלבון ממברנת הפלסמה של הטפיל ליישמניה דונובני | WorldCat.org" (in en). https://www.worldcat.org/title/870836755.
- ↑ "Molecular characterization of an ARF directed GTPase activating protein | WorldCat.org" (in en). https://www.worldcat.org/title/870842990.
- ↑ 6.0 6.1 "3-D Vision Brings New Perspectives" (in en). https://www.aacr.org/professionals/research-funding/grantees/3-d-vision-brings-new-perspectives/.
- ↑ Madhusoodanan, Jyoti (2019-02-26). "Matrix mimics shape cell studies" (in en). Nature 566 (7745): 563–565. doi:10.1038/d41586-019-00681-1. PMID 30809069. Bibcode: 2019Natur.566..563M.
- ↑ 8.0 8.1 8.2 8.3 "Cukierman Named Fellow of the American Gastroenterological Association" (in en). 2020-02-14. https://www.foxchase.org/news/2020-02-14-cukierman-named-fellow-american-gastroenterological-association.
- ↑ 9.0 9.1 9.2 9.3 "Edna (Eti) Cukierman" (in en). 2015-11-03. https://www.foxchase.org/edna-cukierman.
- ↑ "Exploring how a tumour's environment helps it grow" (in en). https://www.worldwidecancerresearch.org/what-we-do/our-research-projects/getting-on-cancers-nerves-exploring-how-the-tumours-environment-helps-it-grow/.
- ↑ 11.0 11.1 "Fox Chase Researcher Receives Grant for Study of Biology of Pancreatic Cancer" (in en). 2020-01-27. https://www.foxchase.org/news/2020-01-27-Cukierman-Fox-Chase-researcher-receives-grant-study-biology-pancreatic-cancer.
- ↑ 12.0 12.1 12.2 Amatangelo, Michael D.; Bassi, Daniel E.; Klein-Szanto, Andrés J. P.; Cukierman, Edna (August 2005). "Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts". The American Journal of Pathology 167 (2): 475–488. doi:10.1016/S0002-9440(10)62991-4. ISSN 0002-9440. PMID 16049333.
- ↑ Franco-Barraza, Janusz; Francescone, Ralph; Luong, Tiffany; Shah, Neelima; Madhani, Raj; Cukierman, Gil; Dulaimi, Essel; Devarajan, Karthik et al. (2017-01-31). Ivaska, Johanna. ed. "Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence". eLife 6: e20600. doi:10.7554/eLife.20600. ISSN 2050-084X. PMID 28139197.
- ↑ Francescone, Ralph; Barbosa Vendramini-Costa, Débora; Franco-Barraza, Janusz; Wagner, Jessica; Muir, Alexander; Lau, Allison N.; Gabitova, Linara; Pazina, Tatiana et al. (2021-02-01). "Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast–Driven Nutritional Support and Immunosuppression" (in en). Cancer Discovery 11 (2): 446–479. doi:10.1158/2159-8290.CD-20-0775. ISSN 2159-8274. PMID 33127842. PMC 7858242. https://aacrjournals.org/cancerdiscovery/article/11/2/446/3018/Netrin-G1-Promotes-Pancreatic-Tumorigenesis.
- ↑ "Edna Cukierman: How Fox Chase is Becoming a Hub for Pancreatic Research" (in en). 2018-07-19. https://www.foxchase.org/blog/2017-11-13-how-fox-chase-is-becoming-a-hub-for-pancreatic-research.
- ↑ "Edna Cukierman" (in en-US). https://www.nikonsmallworld.com/people/edna-cukierman.
- ↑ "Pollen grains | 2005 Photomicrography Competition" (in en-US). https://www.nikonsmallworld.com/galleries/2005-photomicrography-competition/pollen-grains.
- ↑ "Officers". https://www.asmb.net/officers.
- ↑ "Dr. Edna Cukierman, PhD - Editorial Board - Matrix Biology - Journal - Elsevier". https://www.journals.elsevier.com/matrix-biology/editorial-board/journals.elsevier.com/matrix-biology/editorial-board/dr-edna-cukierman-phd.
- ↑ , Wikidata Q29615214
- ↑ , Wikidata Q34667330
- ↑ , Wikidata Q92932998
![]() | Original source: https://en.wikipedia.org/wiki/Edna Cukierman.
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