Biography:Emily Bernstein

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Short description: Medical researcher
Emily Bernstein
Alma materState University of New York at Stony Brook
Scientific career
InstitutionsMount Sinai College of Medicine
ThesisDicer, a novel RNase III, is required for RNA interference and development (2003)
Doctoral advisorGregory Hannon

Emily Bernstein is a professor at Mount Sinai School of Medicine known for her research on RNA interference, epigenetics, and cancer, especially melanoma.

Education and career

Bernstein received her B.S. from McGill University in 1998 and earned a Ph.D. from Stony Brook University in 2003.[1] Following her Ph.D. she was a postdoctoral researcher at Rockefeller University where she worked with David Allis.[2] In 2008 she moved to Mount Sinai School of Medicine where, as of 2022, she is a professor in the department of oncology and dermatology.[3]

Research

Bernstein is known for her research on RNA interference, epigenetics, and cell development. Her early research examined the enzyme Dicer, its role in cell development in mice,[4] and RNA interference.[5] While a postdoctoral researcher she examined linkages between non-coding RNA and chromatin[6][7] and DNA methylation.[8] Subsequently, she has worked on histones,[9][10] gene silencing,[11] and tumor cell development.[12][13] In 2022 her team discovered alterations to a gene which can lead to melanoma.[14][15]

Selected publications

Awards and honors

In 2014 Bernstein received a young investigators award from the Pershing Square Foundation.[16]

References

  1. ↑ "Speakers". 2022-05-15. https://wistar.org/speakers-0. 
  2. ↑ "Investigator | Bernstein Laboratory". 2015-04-16. https://labs.icahn.mssm.edu/bernsteinlab/team/investigator/. 
  3. ↑ "Emily Bernstein | Mount Sinai - New York" (in en-US). https://www.mountsinai.org/profiles/emily-bernstein. 
  4. ↑ Bernstein, Emily; Kim, Sang Yong; Carmell, Michelle A; Murchison, Elizabeth P; Alcorn, Heather; Li, Mamie Z; Mills, Alea A; Elledge, Stephen J et al. (2003-11-01). "Dicer is essential for mouse development" (in en). Nature Genetics 35 (3): 215–217. doi:10.1038/ng1253. ISSN 1061-4036. PMID 14528307. http://www.nature.com/articles/ng1253. 
  5. ↑ Bernstein, Emily; Caudy, Amy A.; Hammond, Scott M.; Hannon, Gregory J. (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference" (in en). Nature 409 (6818): 363–366. doi:10.1038/35053110. ISSN 0028-0836. PMID 11201747. http://www.nature.com/articles/35053110. 
  6. ↑ Bernstein, Emily; Allis, C. David (2005-07-15). "RNA meets chromatin" (in en). Genes & Development 19 (14): 1635–1655. doi:10.1101/gad.1324305. ISSN 0890-9369. PMID 16024654. 
  7. ↑ Bernstein, Emily; Duncan, Elizabeth M.; Masui, Osamu; Gil, Jesus; Heard, Edith; Allis, C. David (2006). "Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin" (in en). Molecular and Cellular Biology 26 (7): 2560–2569. doi:10.1128/MCB.26.7.2560-2569.2006. ISSN 0270-7306. PMID 16537902. 
  8. ↑ Ooi, Steen K. T.; Qiu, Chen; Bernstein, Emily; Li, Keqin; Jia, Da; Yang, Zhe; Erdjument-Bromage, Hediye; Tempst, Paul et al. (2007). "DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA" (in en). Nature 448 (7154): 714–717. doi:10.1038/nature05987. ISSN 0028-0836. PMID 17687327. Bibcode: 2007Natur.448..714O. 
  9. ↑ Gaspar-Maia, Alexandre; Qadeer, Zulekha A.; Hasson, Dan; Ratnakumar, Kajan; Adrian Leu, N.; Leroy, Gary; Liu, Shichong; Costanzi, Carl et al. (2013-06-26). "MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency" (in en). Nature Communications 4 (1): 1565. doi:10.1038/ncomms2582. ISSN 2041-1723. PMID 23463008. Bibcode: 2013NatCo...4.1565G. 
  10. ↑ Vardabasso, Chiara; Hasson, Dan; Ratnakumar, Kajan; Chung, Chi-Yeh; Duarte, Luis F.; Bernstein, Emily (2014). "Histone variants: emerging players in cancer biology" (in en). Cellular and Molecular Life Sciences 71 (3): 379–404. doi:10.1007/s00018-013-1343-z. ISSN 1420-682X. PMID 23652611. 
  11. ↑ Chicas, Agustin; Kapoor, Avnish; Wang, Xiaowo; Aksoy, Ozlem; Evertts, Adam G.; Zhang, Michael Q.; Garcia, Benjamin A.; Bernstein, Emily et al. (2012-06-05). "H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence" (in en). Proceedings of the National Academy of Sciences 109 (23): 8971–8976. doi:10.1073/pnas.1119836109. ISSN 0027-8424. PMID 22615382. Bibcode: 2012PNAS..109.8971C. 
  12. ↑ Sosa, Maria Soledad; Parikh, Falguni; Maia, Alexandre Gaspar; Estrada, Yeriel; Bosch, Almudena; Bragado, Paloma; Ekpin, Esther; George, Ajish et al. (2015). "NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes" (in en). Nature Communications 6 (1): 6170. doi:10.1038/ncomms7170. ISSN 2041-1723. PMID 25636082. Bibcode: 2015NatCo...6.6170S. 
  13. ↑ Strub, Thomas; Ghiraldini, Flavia G.; Carcamo, Saul; Li, Man; Wroblewska, Aleksandra; Singh, Rajendra; Goldberg, Matthew S.; Hasson, Dan et al. (2018). "SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling" (in en). Nature Communications 9 (1): 3440. doi:10.1038/s41467-018-05966-z. ISSN 2041-1723. PMID 30143629. Bibcode: 2018NatCo...9.3440S. 
  14. ↑ "Scientists discover gene mutation that signals aggressive melanoma" (in en). April 6, 2022. https://www.sciencedaily.com/releases/2022/04/220406160555.htm. 
  15. ↑ Carcamo, Saul; Nguyen, Christie B.; Grossi, Elena; Filipescu, Dan; Alpsoy, Aktan; Dhiman, Alisha; Sun, Dan; Narang, Sonali et al. (2022-04-05). "Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma" (in English). Cell Reports 39 (1): 110637. doi:10.1016/j.celrep.2022.110637. ISSN 2211-1247. PMID 35385731. 
  16. ↑ Benson, Barbara (May 5, 2014). "Wall Street funds cancer-research up-and-comers". Crain's New York Business; New York 30 (18): pp. 22. 

External links



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