Biography:Herbert M. Sauro
Herbert M. Sauro | |
|---|---|
| Born | July 1960 (age 63–64) Dyfed, Wales |
| Nationality | British, USA |
| Alma mater | Oxford Brookes University |
| Known for | metabolic control analysis, metabolic regulation, SBML |
| Scientific career | |
| Fields | Biochemistry, Bioengineering, systems biology |
| Institutions | University of Edinburgh, Keck Graduate Institute, University of Washington |
| Thesis | Control analysis and simulation of metabolism (1986) |
| Academic advisors | David Fell |
Herbert M. Sauro works in the field of metabolic control analysis and systems biology.
Education and early life
Sauro was born July 19, 1960, in Dyfed, Wales. He grew up in the village of Llangolman in Pembrokeshire and attended the Welsh comprehensive school Ysgol y Preseli.[1]
Education
After obtaining a B.Sc. in biochemistry with microbiology at the University of Canterbury and an M.Sc. in biological computing at the University of York, Sauro moved to Oxford Brookes University for his Ph.D. (1986) under the direction of David Fell, for a thesis entitled Control analysis and simulation of metabolism, work that led to several publications, including one in which new relationships between elasticities and control coefficients were described.[2] Subsequently he obtained a teaching degree at the University of Aberystwyth.
Research
Sauro carried out post-doctoral research at the University of Edinburgh in association with Henrik Kacser, when he worked on time-dependent systems[3] and enzyme-enzyme interactions.[4][5]
While a student at Oxford Sauro wrote a program called SCAMP for modelling metabolic systems,[6] later developed as Jarnac[7] and incorporated in his Systems Biology Workbench.[8]
Together with Hamid Bolouri, Andrew Finney and Michael Hucka he was a member of the development team for the creation of SBML (the Systems Biology Mark-up language),[9] which has become a major influence on the subject.[10]
In 2018, Sauro's research group published Tellurium, a Python-based modeling environment with applications in system analysis and synthetic biology.[11]
Books
Sauro is the author of books on metabolic control analysis,[12] enzyme kinetics,[13] and Laplace transforms.[14]
Career
After some years, first at Caltech (2000-2005), then at the Keck Graduate Institute in Claremont, California (2004-2007), Sauro moved to the University of Washington as an Associate professor in the department of Bioengineering in 2007.[15][16] In 2013 he earned the University of Washington College of Engineering, Community of Innovators Awards, Faculty Innovator: Teaching & Learning.[17]
He is currently the director of the NIH Center for Reproducible Biomedical Modeling.[18]
References
- ↑ Entry at ORCID
- ↑ Fell, D A; Sauro, H M (1985). "Metabolic control and its analysis: additional relationships between elasticities and control coefficients". Eur. J. Biochem. 148 (3): 555–561. doi:10.1111/j.1432-1033.1985.tb08876.x. PMID 3996393.
- ↑ Acerenza, L; Sauro, H M; Kacser, H (1989). "Control analysis of time-dependent metabolic systems". J. Theor. Biol. 137 (4): 423–444. doi:10.1016/S0022-5193(89)80038-4. PMID 2626059. Bibcode: 1989JThBi.137..423A.
- ↑ Kacser, H; Sauro, H M; Acerenza, L (1990). "Enzyme-enzyme interactions and control analysis. 1. the case of nonadditivity - monomer-oligomer associations". Eur. J. Biochem. 187 (3): 481–491. doi:10.1111/j.1432-1033.1990.tb15329.x. PMID 2406132.
- ↑ Sauro, H M; Kacser, H (1990). "Enzyme-enzyme interactions and control analysis. 2. The case of nonindependence - heterologous association". Eur. J. Biochem. 187 (3): 493–500. doi:10.1111/j.1432-1033.1990.tb15330.x. PMID 2406133.
- ↑ Sauro, H M (1993). "SCAMP: a general-purpose simulator and metabolic control analysis programs". Comput. Appl. Biosci. 9 (4): 441–450. doi:10.1093/bioinformatics/9.4.441. PMID 8402211.
- ↑ Sauro, H M (2000). "Jarnac: a system for interactive metabolic analysis". Stellenbosch University Press. pp. 221–228. ISBN 0-7972-0776-7.
- ↑ Wellock, C; Chickarmane, V; Sauro, H M (2005). "The SBW-MATLAB Interface". Bioinformatics 21 (6): 823–824. doi:10.1093/bioinformatics/bti110. PMID 15531613.
- ↑ Hucka, M.; Finney, A.; Sauro, H. M.; Bolouri, H.; Doyle, J. C.; Kitano, H.; Arkin, A. P.; Bornstein, B. J. et al. (2003). "The systems biology markup language (SBML): A medium for representation and exchange of biochemical network models". Bioinformatics 19 (4): 524–531. doi:10.1093/bioinformatics/btg015. PMID 12611808.
- ↑ More than 2000 citations as of early 2023.
- ↑ Choi, Kiri; Medley, J. Kyle; König, Matthias; Stocking, Kaylene; Smith, Lucian; Gu, Stanley; Sauro, Herbert M. (July 2018). "Tellurium: An extensible python-based modeling environment for systems and synthetic biology". BioSystems 171: 74–79. doi:10.1016/j.biosystems.2018.07.006. ISSN 1872-8324. PMID 30053414.
- ↑ Sauro, H M (2018). Systems Biology: An Introduction to Metabolic Control Analysis (2nd ed.). Ambrosius. ISBN 978-0982477366.
- ↑ Sauro, H M (2023). Enzyme Kinetics for Systems Biology (2nd ed.). Ambrosius Publishing. ISBN 978-0982477335.
- ↑ Sauro, H M (2021). The Little Book of Laplace Transforms. Ambrosius Publishing. ISBN 978-1732548619.
- ↑ https://depts.washington.edu/bpsd/people/faculty/sauro/
- ↑ "Herbert M Sauro". March 14, 2023. https://www.researchgate.net/profile/Herbert-Sauro.
- ↑ "Past award recipients" (in en). 2009-06-25. https://www.engr.washington.edu/mycoe/awards/coera_priorwin.
- ↑ "Center for Reproducible Biomedical Modeling". https://reproduciblebiomodels.org/.
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