Biography:Isabelle M. Germano

Isabelle M. Germano
Education	MD at University of Turin Medical School (1984)
Occupation	Neurosurgeon Professor of neurosurgery, neurology, and oncology
Awards	Best Doctors of New York Hall of Fame (2000) Leksell Radiosurgery Award (2014)

Isabelle M. Germano is an American neurosurgeon and professor of neurosurgery, neurology, and oncology at the Icahn School of Medicine at Mount Sinai Hospital. She is a fellow of the American College of Surgeons and the American Association of Neurological Surgeons. Germano specializes in image-guided brain and spine surgery.

Education

After undergraduate education in Latin and ancient Greek literature, Germano graduated from the University of Turin Medical School in 1984. Her thesis was in neuropathology; she also completed a neurology residency. She completed her surgical internship at the University of California San Francisco and neurosurgery residency at UCSF and the Albert Einstein College of Medicine, completing these in 1993. During her residency, she obtained training in epilepsy surgery at the University Hospital of Zürich, Switzerland. She also completed a fellowship in epilepsy surgery, stereotactic treatments and movement disorders under André Olivier at Montreal Neurological Institute.

Career

In 1992, Germano joined the neurosurgery faculty at Mount Sinai, where she worked on developing treatments for brain tumors and stereotactic clinical programs. She is the director of the comprehensive tumor program and co-director of the radiosurgery program there. She has worked in the field of image-guided brain and spine surgery. Since 2004, she has directed a practical course for neurosurgeons around the world in order to help these technological advances become the standard of care. These technologies are used to perform minimally invasive surgery for patients with brain tumors, epilepsy, Parkinson's disease, movement disorders, and spine disease or tumors. She also established a basic science laboratory within the neurosurgery department to focus on brain tumor translational research with particular emphases on gene therapy, stem cells, and induced pluripotent stem cells (iPSC).

Germano has served on the executive committee of the Congress of Neurological Surgeons (CNS); on the board of directors of the American Association of Neurological Surgeons (AANS); on the executive committee of the AANS/CNS Joint Section on Tumors; and as a scientific committee program member for the AANS, CNS, and the American Epilepsy Society (AES). She was previously president of Women in Neurosurgery (WINS). Germano's clinical interests include newly diagnosed or recurrent brain and spine tumors, brain mapping and monitoring, gliomas, metastasis, meningiomas, brain and spine radiosurgery, epilepsy surgery, and problems of the cervical and lumbar spine.

Honors and awards

• 2000 - Best Doctors of New York Hall of Fame
• 2014 - Leksell Radiosurgery Award
• 2022 - Became the first woman to chair the American Association of Neurological Surgeons and Congress of Neurological Surgeons (AANS/CNS) Section on Tumors. She handed over the post to Costas Hadjipanayis at the end of 2024.

Publications

Books

• Germano IM (Editor). Advanced Techniques in Image-Guided Brain and Spine Surgery. 2002, Thieme Publishers, New York, NY, pages 233 Library of Congress ISBN 1-58890-067-3
• Germano IM (Editor). LINAC and Gamma Knife Radiosurgery. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 295. Library of Congress ISBN 1-879284-70-7 [1]
• Germano IM (Editor). Neurosurgery Treatment of Movement Disorders. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 275 Library of Congress ISBN 978-1-879284-58-6

Papers

• Web-based pathology assessment in RTOG 98-04.
• Mormone, E; D'Sousa, S; Alexeeva, V; Bederson, MM; Germano, IM (2014). ""Footprint-free" human induced pluripotent stem cell-derived astrocytes for in vivo cell-based therapy". Stem Cells Dev 23 (21): 2626–36. doi:10.1089/scd.2014.0151. PMID 24914471. 
• Douglas, AC; Wippold, FJ; Broderick, DF; Aiken, AH; Amin-Hanjani, S; Brown, DC; Corey, AS; Germano, IM et al. (Jul 2014). "ACR Appropriateness Criteria Headache". J Am Coll Radiol 11 (7): 657–67. doi:10.1016/j.jacr.2014.03.024. PMID 24933450. 
• Lo, SS; Gore, EM; Bradley, JD; Buatti, JM; Germano, IM; Ghafoori, AP; Henderson, MA; Murad, GJ et al. (2014). "ACR Appropriateness Criteria Pre-Irradiation Evaluation and Management of Brain Metastases". J Palliat Med 17 (8): 880–886. doi:10.1089/jpm.2014.9417. PMID 24971478. 
• Germano, IM; Binello. "past, present, and future". J Neuro-Oncology. 
• Binello, E; Mormone, E; Emdad, L; Kothari, H; Germano, IM (2014). "Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade gliomas and anti-invasive effects on glioma stem cells". J Neurooncol 117 (2): 225–34. doi:10.1007/s11060-014-1385-6. PMID 24493576. 
• Barthélemy, EJ; Benjamin, E; Edouard Jean-Pierre, MY; Poitevien, G; Ernst, S; Osborn, I; Germano, IM (2014). "A prospective emergency department-based study of pattern and outcome of neurologic and neurosurgical diseases in Haiti". World Neurosurg 82 (6): 948–53. doi:10.1016/j.wneu.2013.10.012. PMID 24121294. 
• Binello, E; Qadeer, ZA; Kothari, HP; Emdad, L; Germano, IM (2012). "Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization In Vitro". J Cancer 3: 166–74. doi:10.7150/jca.4149. PMID 22514559. 
• Binello, E; Germano, IM (2012). "Stem cells as therapeutic vehicles for the treatment of high-grade gliomas". Neuro Oncol 14 (3): 256–65. doi:10.1093/neuonc/nor204. PMID 22166262. 
• Emdad, L; D'Souza, SL; Kothari, HP; Qadeer, ZA; Germano, IM (2012). "Efficient differentiation of human embryonic and induced pluripotent stem cells into functional astrocytes". Stem Cells Dev 21 (3): 404–10. doi:10.1089/scd.2010.0560. PMID 21631388. 
• Patel, SH; Robbins, JR; Gore, EM; Bradley, JD; Gaspar, LE; Germano, I; Ghafoori, P; Henderson, MA et al. (2012). "ACR Appropriateness Criteria® follow-up and retreatment of brain metastases". Am J Clin Oncol 35 (3): 302–6. doi:10.1097/COC.0b013e31824be246. PMID 22609733. 
• Binello, E; Germano (2011). "a novel framework for brain tumors". Cancer Sci 102 (11): 1958–1966. doi:10.1111/j.1349-7006.2011.02064.x. PMID 21848914. 
• Binello, E; Green, S; Germano, IM (2012). "Radiosurgery for high-grade glioma". Surg Neurol Int 3 (3): S118-26. doi:10.4103/2152-7806.95423. PMID 22826815. 
• Patel, SH; Robbins, JR; Gore, EM; Bradley, JD; Gaspar, LE; Germano, I; Ghafoori, P; Henderson, MA et al. (2012). "ACR Appropriateness Criteria® follow-up and retreatment of brain metastases". Am J Clin Oncol 35 (3): 302–6. doi:10.1097/COC.0b013e31824be246. PMID 22609733. 
• Emdad, L; Qadeer, ZA; Bederson, LB; Kothari, HP; Uzzaman, M; Germano, IM (2011). "Is there a common upstream link for autophagic and apoptotic cell death in human high-grade gliomas?". Neuro Oncol 13 (7): 725–35. doi:10.1093/neuonc/nor053. PMID 21727211. 
• Germano, IM; Emdad, L; Qadeer, ZA; Binello, E; Uzzaman, M (2010). "Embryonic stem cell (ESC)-mediated transgene delivery induces growth suppression, apoptosis and radiosensitization, and overcomes temozolomide resistance in malignant gliomas". Cancer Gene Ther 17 (9): 664–74. doi:10.1038/cgt.2010.31. PMID 20523363. .
• Germano, I; Swiss, V; Casaccia, P (2010). "Primary brain tumors, neural stem cell, and brain tumor cancer cells: where is the link?". Neuropharmacology 58 (6): 903–10. doi:10.1016/j.neuropharm.2009.12.019. PMID 20045420. 
• Suh, JH; Videtic, GM; Aref, AM; Germano, I; Goldsmith, BJ; Imperato, JP; Marcus, KJ; McDermott, MW et al. (2010). "ACR Appropriateness Criteria: single brain metastasis". Curr Probl Cancer 34 (3): 162–74. doi:10.1016/j.currproblcancer.2010.04.003. PMID 20541055. 
• Germano, IM; Binello, E (2009). "Gene therapy as an adjuvant treatment for malignant gliomas: from bench to bedside". J Neurooncol 93 (1): 79–87. doi:10.1007/s11060-009-9869-5. PMID 19430884. 
• Binello, E.; Germano, I. M. (Aug 2009). "Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology?". J Neurooncol 94 (1): 145–8. doi:10.1007/s11060-009-9806-7. PMID 19199004. 
• Uzzaman, M; Keller, G; Germano, IM (2009). "In vivo gene delivery by embryonic-stem-cell-derived astrocytes for malignant gliomas". Neuro Oncol 11 (2): 102–8. doi:10.1215/15228517-2008-056. PMID 18676359. 
• Videtic, GM; Gaspar, LE; Aref, AM; Germano, IM; Goldsmith, BJ; Imperato, JP; Marcus, KJ; McDermott, MW et al. (2009). "American College of Radiology appropriateness criteria on multiple brain metastases". Int J Radiat Oncol Biol Phys 75 (4): 961–5. doi:10.1016/j.ijrobp.2009.07.1720. PMID 19857783. 
• Wood, A; Ashhurst, DE; Corbett, A; Thorogood, P (1991). "The transient expression of type II collagen at tissue interfaces during mammalian craniofacial development". Development 111 (4): 955–68. doi:10.1242/dev.111.4.955. PMID 1879364. 
• Benzil, DL; Abosch, A; Germano, I; Gilmer, H; Maraire, JN; Muraszko, K; Pannullo, S; Rosseau, G et al. (2008). "The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery". J Neurosurg 109 (3): 378–86. doi:10.3171/JNS/2008/109/9/0378. PMID 18759565. 
• Uzzaman, M; Keller, G; Germano, IM (2007). "Enhanced proapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on temozolomide-resistant glioma cells". J Neurosurg 106 (4): 646–51. doi:10.3171/jns.2007.106.4.646. PMID 17432717. 
• Germano, Isabelle M.; Uzzaman, Mahmud; Benveniste, Ronald J.; Zaurova, Milana; Keller, Gordon (Jul 2006). "Apoptosis in human glioblastoma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand.". J Neurosurg 105 (1): 88–95. doi:10.3171/jns.2006.105.1.88. PMID 16871882. 
• Uzzaman, M; Benveniste, RJ; Keller, G; Germano, IM (2005). "Embryonic stem cell-derived astrocytes: a novel gene therapy vector for brain tumors". Neurosurg Focus 19 (3): E6. doi:10.3171/foc.2005.19.3.7. PMID 16190605. 
• Benveniste, RJ; Keller, G; Germano, I (2005). "Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: differentiation and transplantion into the mouse brain". J Neurosurg 103 (1): 115–23. doi:10.3171/jns.2005.103.1.0115. PMID 16121982. 
• Benveniste, RJ; Germano, IM (2005). "Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques". Surg Neurol 63 (6): 542-8; discussion 548-9. doi:10.1016/j.surneu.2004.11.025. PMID 15936381. 
• Kanzawa, T; Zhang, L; Xiao, L; Germano, IM; Kondo, Y; Kondo, S (2005). "Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein BNIP3". Oncogene 24 (6): 980–91. doi:10.1038/sj.onc.1208095. PMID 15592527. 
• Germano, IM; Gracies, JM; Weisz, DJ; Tse, W; Koller, WC; Olanow, CW (2004). "Unilateral stimulation of the subthalamic nucleus in Parkinson disease: a double-blind 12-month evaluation study". J Neurosurg 101 (1): 36–42. doi:10.3171/jns.2004.101.1.0036. PMID 15255249. 

External links

• Mount Sinai profile
• Device tested to treat aggressive brain tumors
• CDI^[Usurped!]
• ACR Appropriateness Criteria Headache