Biography:Lydia W. S. Finley

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Short description: American biologist
Lydia W. S. Finley
AwardsSearle Scholar
Scientific career
FieldsMetabolism, Stem Cell Biology
InstitutionsMemorial Sloan Kettering
Doctoral advisorMarcia Haigis
Other academic advisorsCraig Thompson
Websitehttps://www.mskcc.org/research/ski/labs/lydia-finley

Lydia W. S. Finley is an American scientist and an assistant member at the Cell Biology Program at Memorial Sloan Kettering Cancer Center and an assistant professor at Weill Cornell Medical College. Finley is known for her contributions to understanding the metabolic underpinnings of stem cell fate.

Biography

Finley received her Bachelor of Science (BS) degree summa cum laude from Yale University. Finley completed her PhD at Harvard Medical School, where she worked in the laboratory of Marcia Haigis. Finley then worked as a postdoctoral fellow in the laboratory of Craig Thompson at Memorial Sloan Kettering Cancer Center. After completing her postdoctoral work, Finley opened her own laboratory in 2017, which is located in the Memorial Sloan Kettering Cancer Center.[1][2][3]

Finley has received various awards for her work. These include the Dale F. Frey Award for Breakthrough Scientists from the Damon Runyon Cancer Research Foundation and the Searle Scholars Award. Finley currently serves as an associate editor for Cancer & Metabolism[4] and a reviewing editor at eLife.[5] As of April 2022, Finley has authored over 40 publications and has an h-index of 30.[6]

Scientific contributions

Finley's research has focused on interrogating the connections between metabolites and their role in regulating embryonic stem cell self-renewal and cell fate decisions. Notably, as a postdoctoral fellow, Finley and Bryce W. Carey discovered that intracellular α-ketoglutarate levels regulated chromatin and gene expression, and contributes to embryonic stem cell renewal.[7][8] In 2022, Finley and co-authors published a paper describing a non-canonical arm of the TCA cycle.[9][10][11][12]

Selected awards and honors

  • National Science Foundation Graduate Research Fellowship
  • Dale F. Frey Award for Breakthrough Scientists, Damon Runyon Cancer Research Foundation[13]
  • 2018: Searle Scholar[14]
  • 2020: Pershing Square Sohn Cancer Research Alliance Award[15]

Selected publications

  • Carey BW*, Finley LW*, Cross JR, Allis CD, Thompson CB. Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature. 2015;518(7539):413-416. doi:10.1038/nature13981[16]
  • Arnold PK, Jackson BT, Paras KI, Brunner JS, Hart ML, Newsom OJ, Alibeckoff SP, Endress J, Drill E, Sullivan LB, Finley LWS. A non-canonical tricarboxylic acid cycle underlies cellular identity. Nature. 2022 Mar;603(7901):477-481. doi: 10.1038/s41586-022-04475-w. Epub 2022 Mar 9. PMID: 35264789; PMCID: PMC8934290.[17]

References

  1. ↑ "Lydia Finley, PhD" (in en-US). https://psscra.org/winners/lydia-finley-phd/. 
  2. ↑ "Lydia Finley | Haigis Lab". https://haigis.hms.harvard.edu/people/lydia-finley. 
  3. ↑ "Cell scientist to watch – Lydia Finley". Journal of Cell Science 135 (7): jcs260023. 2022-04-04. doi:10.1242/jcs.260023. ISSN 0021-9533. https://doi.org/10.1242/jcs.260023. 
  4. ↑ "Cancer & Metabolism" (in en). https://cancerandmetabolism.biomedcentral.com/. 
  5. ↑ "Editors for Stem Cells and Regenerative Medicine" (in en). https://elifesciences.org/about/people/stem-cells-regenerative-medicine. 
  6. ↑ "Lydia Finley". https://scholar.google.com/citations?user=yuzqXb0AAAAJ&hl=en. 
  7. ↑ "Cell scientist to watch – Lydia Finley". Journal of Cell Science 135 (7): jcs260023. 2022-04-04. doi:10.1242/jcs.260023. ISSN 0021-9533. https://doi.org/10.1242/jcs.260023. 
  8. ↑ Carey, Bryce W.; Finley, Lydia W.S.; Cross, Justin R.; Allis, C. David; Thompson, Craig B. (2015-02-19). "Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells". Nature 518 (7539): 413–416. doi:10.1038/nature13981. ISSN 0028-0836. PMID 25487152. Bibcode: 2015Natur.518..413C. 
  9. ↑ Arnold, Paige K.; Jackson, Benjamin T.; Paras, Katrina I.; Brunner, Julia S.; Hart, Madeleine L.; Newsom, Oliver J.; Alibeckoff, Sydney P.; Endress, Jennifer et al. (March 2022). "A non-canonical tricarboxylic acid cycle underlies cellular identity". Nature 603 (7901): 477–481. doi:10.1038/s41586-022-04475-w. ISSN 1476-4687. PMID 35264789. Bibcode: 2022Natur.603..477A. 
  10. ↑ "Sloan Kettering Institute Scientists Discover a new twist on an 80-year-old biochemical pathway" (in en). https://www.eurekalert.org/news-releases/945933. 
  11. ↑ "New twist on an 80-year-old biochemical pathway" (in en). https://www.sciencedaily.com/releases/2022/03/220309131858.htm. 
  12. ↑ "Remember Memorizing the Krebs Cycle? An Alternate Version Was Just Discovered | Cell And Molecular Biology". https://www.labroots.com/trending/cell-and-molecular-biology/22405/remember-memorizing-krebs-cycle-alternate-version-discovered. 
  13. ↑ "Meet Our Scientists" (in en). https://www.damonrunyon.org/our-impact/current-projects/scientists/3321. 
  14. ↑ "Lydia Finley" (in en). https://www.searlescholars.net/people/lydia-finley. 
  15. ↑ "Lydia Finley, PhD" (in en-US). https://psscra.org/winners/lydia-finley-phd/. 
  16. ↑ Carey, Bryce W.; Finley, Lydia W.S.; Cross, Justin R.; Allis, C. David; Thompson, Craig B. (2015-02-19). "Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells". Nature 518 (7539): 413–416. doi:10.1038/nature13981. ISSN 0028-0836. PMID 25487152. Bibcode: 2015Natur.518..413C. 
  17. ↑ Arnold, Paige K.; Jackson, Benjamin T.; Paras, Katrina I.; Brunner, Julia S.; Hart, Madeleine L.; Newsom, Oliver J.; Alibeckoff, Sydney P.; Endress, Jennifer et al. (March 2022). "A non-canonical tricarboxylic acid cycle underlies cellular identity". Nature 603 (7901): 477–481. doi:10.1038/s41586-022-04475-w. ISSN 1476-4687. PMID 35264789. Bibcode: 2022Natur.603..477A. 



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