Biography:Makoto Furutani-Seiki
Makoto Furutani-Seiki | |
|---|---|
| Nationality | Japanese |
| Other names | Makoto Seiki |
| Alma mater | Yamaguchi University, University of Tokyo |
| Scientific career | |
| Fields | Immunology
Developmental Genetics Regenerative Medicine Cancer |
| Institutions | Yamaguchi University
University of Tokyo Max Planck Institute for Developmental Biology, Germany University of Freiburg, Germany Kumamoto University University of Bath, UK |
| Doctoral advisor | Tomio Tada |
| Website | https://researchmap.jp/7000021820?lang=en |
Makoto Furutani-Seiki is a Japanese molecular biologist who is a Professor of Systems Biochemistry in the School of Medicine at Yamaguchi University, Japan.[1][2]
Education
Furutani-Seiki was educated at the Yamaguchi University School of Medicine, Japan where he was awarded Doctor of Medicine (M.D) in 1985.[3][4][5][6] He completed his postgraduate study at the Department of Immunology, Graduate School of Medicine, University of Tokyo, Japan where he was awarded a Ph.D in Immunology supervised by Tomio Tada in 1989.[7][8]
Career and research
Furutani-Seiki started his career in 1989, as an assistant professor in Tomio Tada's lab in the Department of Immunology at the University of Tokyo where he investigated the complement factor B for HIV infection. In1992, he participated in the first large-scale mutagenesis screen for mutations affecting embryonic development as a postdoc in Janni Nusslein-Volhard's lab at Max-Planck-Institute in Tübingen. In 1997, he moved to Freiburg University as a group leader to analyze anterior posterior patterning of zebrafish nervous system and envisaged that a mutagenesis screening in medaka fish could identify new phenotypes that could not be identified in the zebrafish mutant screeing. In 2000, he started the first genome-wide mutagenesis screen using medaka fish as a group leader of the Kondoh Differentiation Signalling ERATO project in Kyoto, Japan.[9][10][8] A third of the phenotype identified in the Kyoto medaka screening were not seen in the zebrafish Tübingen screening.
In 2007, he moved to University of Bath, UK, Centre for Regenerative Medicine as a Medical Research Council Senior Research Fellow and continues his research at Yamaguchi University School of Medicine, Japan.[4][8][5][11]
Furutani-Seiki research study investigates the molecular mechanisms of mechono-homeostasis in which extracellular mechanical cues are integrated with cell differentiation and proliferation to maintain tissue, organ and body form.[12]
As part of his contribution to the field of Science, Furutani-Seiki discovered a single gene whose product is essential for the body and organs to keep their 3D shape and withstand external forces such as gravity.[13] The gene was discovered through the analysis of a medaka fish mutant with a unique flattened phenotype which was identified by the combination of the mutagenesis screen in zebrafish with another screen in medaka fish.[14] His work further investigates the single cell lineage and regionalisation of cell populations during medaka neurulation.[13][15]
Furutani-Seiki led an international team of researchers from the University of Bath, UK Centre for Regenerative Medicine that identified a gene that helps the body resist gravity and demonstrated what happens when the system goes wrong.[16] (As of June 2018), he held a visiting professorship in Bath's Department of Biology and Biochemistry.[2]
Awards and honours
Furutani-Seiki is an alumnus of Kavli Frontiers of Science and a member of the editorial board of Regenerative Medicine.[17] He's also a Senior Research Fellow UK of the Medical Research Council (MRC).[8] He's also a professional member of the American Association of Cancer Research and the Molecular Biology Society of Japan.[4]
Selected publications
- Haffter, P.; Odenthal, Jörg; Mullins, M. C.; Lin, Shuo; Farrell, Michael J.; Vogelsang, E.; Haas, F.; Brand, M. et al. (1996-11-01). "Mutations affecting pigmentation and shape of the adult zebrafish" (in en). Development Genes and Evolution 206 (4): 260–276. doi:10.1007/s004270050051. ISSN 1432-041X. PMID 24173565. https://doi.org/10.1007/s004270050051.
- Furutani-Seiki, Makoto; Wittbrodt, Joachim (2004-07-01). "Medaka and zebrafish, an evolutionary twin study" (in en). Mechanisms of Development 121 (7): 629–637. doi:10.1016/j.mod.2004.05.010. ISSN 0925-4773. PMID 15210172.
- Seo, Jungwon; Asaoka, Yoichi; Nagai, Yoko; Hirayama, Jun; Yamasaki, Tokiwa; Namae, Misako; Ohata, Shinya; Shimizu, Nao et al. (2010-07-01). "Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation". Journal of Cellular Biochemistry 110 (4): 1022–1037. doi:10.1002/jcb.22616. ISSN 1097-4644. PMID 20564202. https://pubmed.ncbi.nlm.nih.gov/20564202/.
- Porazinski, Sean R.; Wang, Huijia; Furutani-Seiki, Makoto (2011). "Essential Techniques for Introducing Medaka to a Zebrafish Laboratory—Towards the Combined Use of Medaka and Zebrafish for Further Genetic Dissection of the Function of the Vertebrate Genome". Vertebrate Embryogenesis. Methods in Molecular Biology. 770. pp. 211–241. doi:10.1007/978-1-61779-210-6_8. ISBN 978-1-61779-209-0. https://pubmed.ncbi.nlm.nih.gov/21805266/.
- Miyamoto, Tatsuo; Porazinski, Sean; Wang, Huijia; Borovina, Antonia; Ciruna, Brian; Shimizu, Atsushi; Kajii, Tadashi; Kikuchi, Akira et al. (2011-05-15). "Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates". Human Molecular Genetics 20 (10): 2058–2070. doi:10.1093/hmg/ddr090. ISSN 0964-6906. PMID 21389084. https://doi.org/10.1093/hmg/ddr090.
- Taniguchi, Yoshihito; Takeda, Shunichi; Furutani-Seiki, Makoto; Kamei, Yasuhiro; Todo, Takeshi; Sasado, Takao; Deguchi, Tomonori; Kondoh, Hisato et al. (2006-12-08). "Generation of medaka gene knockout models by target-selected mutagenesis". Genome Biology 7 (12): R116. doi:10.1186/gb-2006-7-12-r116. ISSN 1474-760X. PMID 17156454.
- Porazinski, Sean; Wang, Huijia; Asaoka, Yoichi; Behrndt, Martin; Miyamoto, Tatsuo; Morita, Hitoshi; Hata, Shoji; Sasaki, Takashi et al. (2015-03-16). "YAP is essential for tissue tension to ensure vertebrate 3D body shape". Nature 521 (7551): 217–221. doi:10.1038/nature14215. ISSN 1476-4687. PMID 25778702. PMC 4720436. Bibcode: 2015Natur.521..217P. https://www.scienceopen.com/document?vid=31159260-3b09-47f0-ac49-f1af34e0b249.
- Kitagawa, Takao; Kobayashi, Daiki; Baron, Byron; Okita, Hajime; Miyamoto, Tatsuo; Takai, Rie; Paudel, Durga; Ohta, Tohru et al. (2022-05-16). "AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewing's sarcoma cells" (in en). PLOS ONE 17 (10): 2022.05.16.492174. doi:10.1101/2022.05.16.492174. PMID 36194562. PMC 9531837. https://www.biorxiv.org/content/10.1101/2022.05.16.492174v1.
- Shibata, Kensuke; Shimizu, Takashi; Nakahara, Mashio; Ito, Emi; Legoux, Francois; Fujii, Shotaro; Yamada, Yuka; Furutani-Seiki, Makoto et al. (2022-10-01). "The intracellular pathogen Francisella tularensis escapes from adaptive immunity by metabolic adaptation" (in en). Life Science Alliance 5 (10): e202201441. doi:10.26508/lsa.202201441. ISSN 2575-1077. PMID 35667686. PMC 9170078. https://www.life-science-alliance.org/content/5/10/e202201441.
References
- ↑ "Members". Yamaguchi University Graduate School of Medicine. http://ds.cc.yamaguchi-u.ac.jp/~biochem1/members.html. Retrieved 20 June 2023.
- ↑ 2.0 2.1 "University welcomes visitors from Yamaguchi University". University of Bath. 29 June 2018. https://www.bath.ac.uk/announcements/university-welcomes-visitors-from-yamaguchi-university/. Retrieved 20 June 2023.
- ↑ "Makoto Furutani-Seiki | Yamaguchi University | Research contributor in Zebrafish, Hippo signaling pathway" (in en). https://typeset.io/authors/makoto-furutani-seiki-2r9i0057wi.
- ↑ 4.0 4.1 4.2 "清木 誠 (Seiki Makoto) - 米国癌学会 - 所属学協会 - researchmap". https://researchmap.jp/7000021820/association_memberships/9919554.
- ↑ 5.0 5.1 "Makoto Furutani-Seiki". https://0-scholar-google-com.brum.beds.ac.uk/citations?user=lhYUWTEAAAAJ&hl=en.
- ↑ "NBRP Medaka" (in en). https://shigen.nig.ac.jp/medaka/strain/mta.jsp;jsessionid=627879B3F89F3AB3360A3F36E644B29E.
- ↑ "Mechanical Force Mediated 3D Organogenesis Withstanding Gravity Controlled by YAP - EPFL". https://memento.epfl.ch/event/mechanical-force-mediated-3d-organogenesis-withsta/.
- ↑ 8.0 8.1 8.2 8.3 "CDB Symposium 2016". http://www.cdb.riken.jp/sympo2016/speakers/05j.html.
- ↑ "Former Groups — Institut für Biologie I (Zoologie)". https://www.bio1.uni-freiburg.de/ebio-en/ebiogroup-en.
- ↑ "ZFIN Person: Furutani-Seiki, Makoto". https://zfin.org/ZDB-PERS-960805-194.
- ↑ "Protocols and Video Articles Authored by Makoto Furutani-Seiki" (in en). https://www.jove.com/author/Makoto_Furutani-Seiki.
- ↑ Asaoka, Yoichi; Furutani-Seiki, Makoto (2017-12-01). "YAP mediated mechano-homeostasis — conditioning 3D animal body shape" (in en). Current Opinion in Cell Biology. Cell Differentiation and Development 49: 64–70. doi:10.1016/j.ceb.2017.11.013. ISSN 0955-0674. PMID 29253723. https://www.sciencedirect.com/science/article/pii/S0955067417301473.
- ↑ 13.0 13.1 "Single cell lineage and regionalization of cell populations during Medaka neurulation." (in en). https://www.bioseek.eu/us/eng/research/pubmed/Single_cell_lineage_and_regionalization_of_cell_populations_during_Medaka_neurulation_15148299.
- ↑ Hammerschmidt, M.; Pelegri, F.; Mullins, M.C.; Kane, D.A.; Brand, M.; van Eeden, F.J.; Furutani-Seiki, M.; Granato, M. et al. (1996-12-01). "Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio". Development 123 (1): 143–151. doi:10.1242/dev.123.1.143. ISSN 0950-1991. PMID 9007236. https://doi.org/10.1242/dev.123.1.143.
- ↑ Hirose, Yukihiro; Varga, Zoltan M.; Kondoh, Hisato; Furutani-Seiki, Makoto (2004-06-01). "Single cell lineage and regionalization of cell populations during Medaka neurulation". Development 131 (11): 2553–2563. doi:10.1242/dev.01140. ISSN 0950-1991. PMID 15148299.
- ↑ "Gravity-resisting gene stops our bodies being squashed flat". https://www.bath.ac.uk/announcements/gravity-resisting-gene-stops-our-bodies-being-squashed-flat/.
- ↑ "Regenerative Medicine Research". https://www.regenmedres-journal.org/about-the-journal/editorial-board.
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