Biography:Nicholas P. Restifo
Nicholas P. Restifo | |
|---|---|
| Born | 24 July 1960 Columbus, Ohio |
| Nationality | American |
| Education | Johns Hopkins University, New York University School of Medicine |
| Occupation | Immunologist |
| Known for | T cell-based immunotherapy |
Nicholas P. Restifo (born July 24, 1960) is an American immunologist, physician and educator in cancer immunotherapy. Until July 2019, he was a tenured senior investigator in the intramural National Cancer Institute of the National Institutes of Health at Bethesda, Maryland.[1][self-published source?] Nicholas was an executive vice president of research at Lyell based in San Francisco.
Restifo has been a pioneer in the use of T cell-based immunotherapy.
Early life and education
Restifo was born July 24, 1960, in Columbus, Ohio. He grew up in a small town, Amherst, Ohio, and went to high school in Lorain, Ohio. He completed his undergraduate education with honors at the Johns Hopkins University and obtained his medical degree from New York University School of Medicine. He first joined the National Cancer Institute, NIH in Bethesda, Maryland in 1989. He was recruited from the Memorial Sloan Kettering Cancer Center, where he worked in the laboratory of Murray Brennan, the former chairman of Surgery. He became a principal investigator[2] in 1993 and has authored or co-authored more than 350 papers and book chapters on cancer immunotherapy.[3] His h-index is 156 and his work has been cited more than 104,000 times according to Google Scholar.[4]
Research
Restifo is a pioneer in the field of cancer immunotherapy with a focus on the use of T cells in the treatment of malignancy.[5] One of Dr. Restifo's major discoveries is that CD8+ T cells experience a stereotypical maturational program.[6] His early work was focused on discovering how tumor cells can escape from T cell recognition.[7][8] He went on to characterize the mechanisms underlying why T cells survive and expand better after lymphodepletion.[9] His most recent efforts include a focus on how elements – literally from the periodic table – influence cancer immunity. These include work on how oxygen can inhibit anti-tumor immunity [10] and how potassium ions from dying cancer cells can shut down the anti-tumor response.[11]
Successful treatment of patients with cancer is the goal of his laboratory, and his therapeutic approaches employ adoptive T cell transfer, gene modification and cellular reprogramming.[12] Basic aspects of tumor and T cell immunology inform novel therapeutic interventions in the clinic.
Restifo and his research team have made contributions to the fields of adoptive cell transfer[12] tumor immune-escape,[13][14] virally encoded cancer vaccines,[15] adoptive cell transfer for the treatment of cancer, and the biology of self/tumor-reactive T cells, with an emphasis on memory CD8+ T cells.[16]
Awards
Solomon A. Berson Prize for Clinical and Translational Science, 2017 Clarivate Analytics, “World’s Most Influential Scientific Minds” Double Citation in Immunology and Clinical Medicine 2014 (Thomson Reuters) NIH Director’s Award, 2017, Federal Technology Transfer Award, 2017 Primary Organizer of four Keystone Symposia and three International Cancer Immunotherapy Meetings at NIH. Plenary and Keynote Invited talks at AACR, SITC, ASH, ASCGT, AAI and other meetings.
Academic Appointments, primary mentor for PhD students: 2014 Cambridge University, UK; 2011 U of Pennsylvania School of Medicine; 2010 Georgetown U School of Medicine; 2009 George Wash U School of Medicine.
See also
- Cytotoxic T cell
- interleukin 15
- memory t cell
- Cish
References
- ↑ "Nicholas P. Restifo, M.D.". National Cancer Institute. September 12, 2009. http://ccr.cancer.gov/staff/staff.asp?profileid=5762.
- ↑ "Nicholas P. Restifo, M.D. | Center for Cancer Research". https://ccr.cancer.gov/Surgery-Branch/nicholas-p-restifo?qt-staff_profile_tabs=3#qt-staff_profile_tabs.
- ↑ Search Results for author Restifo NP on PubMed.
- ↑ "Nicholas P Restifo, MD". https://scholar.google.com/citations?user=LVBMEQ8AAAAJ&hl=en.
- ↑ Rosenberg, Steven A.; Restifo, Nicholas P. (2015). "Adoptive cell transfer as personalized immunotherapy for human cancer". Science 348 (6230): 62–68. doi:10.1126/science.aaa4967. PMID 25838374. Bibcode: 2015Sci...348...62R.
- ↑ Gattinoni, L., Lugli, E., Ji, Y. et al. A human memory T cell subset with stem cell–like properties. Nat Med 17, 1290–1297 (2011). https://doi.org/10.1038/nm.2446
- ↑ Nicholas P. Restifo, Francesco M. Marincola, Yutaka Kawakami, Jeff Taubenberger, John R. Yannelli, Steven A. Rosenberg, Loss of Functional Beta 2 -Microglobulin in Metastatic Melanomas From Five Patients Receiving Immunotherapy , JNCI: Journal of the National Cancer Institute, Volume 88, Issue 2, 17 January 1996, Pages 100–108, https://doi.org/10.1093/jnci/88.2.100
- ↑ Identification of Human Cancers Deficient in Antigen Processing
- ↑ DOI:https://doi.org/10.1016/j.it.2004.12.003
- ↑ "Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche". Cell 166 (5): 1117–1131. Aug 25, 2016. doi:10.1016/j.cell.2016.07.032. PMID 27565342.
- ↑ Eil, R, et al. Ionic immune suppression within the tumour microenvironment limits T cell effector function. Nature. 2016 Sep 14. doi: 10.1038/nature19364. [Epub ahead of print]
- ↑ 12.0 12.1 "Adoptive immunotherapy for cancer: harnessing the T cell response". Nature Reviews Immunology 12 (4): 269–81. March 2012. doi:10.1038/nri3191. PMID 22437939.
- ↑ "Identification of human cancers deficient in antigen processing". The Journal of Experimental Medicine 177 (2): 265–72. February 1993. doi:10.1084/jem.177.2.265. PMID 8426105.
- ↑ "Natural selection of tumor variants in the generation of "tumor escape" phenotypes". Nature Immunology 3 (11): 999–1005. November 2002. doi:10.1038/ni1102-999. PMID 12407407.
- ↑ "Synthetic Oligonucleotide Expressed by a Recombinant Vaccinia Virus Elicits Therapeutic CTL". Journal of Immunology 154 (9): 4651–7. May 1995. doi:10.4049/jimmunol.154.9.4651. PMID 7722317. PMC 1976247. http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=7722317.
- ↑ Gattinoni, Luca; Zhong, Xiao-Song; Palmer, Douglas C.; Ji, Yun; Hinrichs, Christian S.; Yu, Zhiya; Wrzesinski, Claudia; Boni, Andrea et al. (July 29, 2009). "Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells". Nature Medicine 15 (7): 808–813. doi:10.1038/nm.1982. PMID 19525962.
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