Biography:Noah Rosenberg

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Short description: American scientist
Noah A. Rosenberg
Noah rosenberg 2023 06.jpg
Alma materRice University
Spouse(s)Donna Zulman, MD
AwardsFellow of the American Association for the Advancement of Science
Scientific career
FieldsPopulation genetics
Phylogenetics
Mathematical and theoretical biology
ThesisStatistical modeling of genetic histories and relationships of populations (2001)
Doctoral advisorMarcus Feldman[1]
Websiterosenberglab.stanford.edu

Noah Aubrey Rosenberg is a geneticist working in evolutionary biology, mathematical phylogenetics, and population genetics, and is the Stanford Professor of Population Genetics and Society.[2] His research focuses on mathematical modeling and statistical methods for genetics and evolution[3] and he is the editor-in-chief of Theoretical Population Biology.[4]

Education

Rosenberg graduated from the Illinois Mathematics and Science Academy in 1993, where he began the mathematical reference known as The Noah Sheets.[5] He earned a BA in mathematics from Rice University in 1997, where he scored among the top 100 students in the Putnam Competition.[6] Rosenberg earned an MS in mathematics from Stanford University in 1999 and a PhD in biology from Stanford University in 2001 under the supervision of Marcus Feldman.[7] His dissertation was titled "Statistical modeling of genetic histories and relationships of populations."[8] Part of his dissertation work was recognized as The Lancet's 2003 paper of the year.[9] From 2001 to 2005, Rosenberg was a postdoctoral fellow at the University of Southern California.[7]

Career

Rosenberg was a professor at the University of Michigan from 2005 to 2011, where he held appointments in the Department of Human Genetics, the Department of Ecology and Evolutionary Biology, and the Department of Biostatistics. He joined the Stanford University Department of Biology as an associate professor in 2011 and was promoted to full professor in 2014, when he was named the Stanford Professor of Population Genetics and Society.[2] He is a member of Stanford's Institute for Computational and Mathematical Engineering (ICME) and Stanford Bio-X.[10][11] Rosenberg was elected as a fellow of the American Association for the Advancement of Science in 2018.[12]

Rosenberg has published more than 150 peer-reviewed articles and has advised more than 35 doctoral students and postdoctoral fellows.[6] His trainees have gone on to professorships at universities including Cornell University,[13] Duke University,[14] the MD Anderson Cancer Center,[15] and the University of Southern California.[16][17]

Rosenberg has served as the editor-in-chief of the journal Theoretical Population Biology since 2013[4] and has served as an associate editor for scientific journals including Genetics and Evolution, Medicine, and Public Health.[18] He is also a co-director of the Stanford Center for Computational, Evolutionary, and Human Genomics.[19] In 2018, Rosenberg started the Stanford X-Tree Project, a website illustrating concepts from phylogenetics using photographs of real trees from the Stanford campus.[20]

Research

Much of Rosenberg's work has analyzed global patterns of genetic and linguistic variation,[9][21][22][23] including developing software for the analysis and visualization of population ancestry data.[24][25] He has also studied the genetic histories of specific people groups, such as the Ohlone Indigenous population of California,[26] African Americans,[27] and Jewish populations.[28]

Rosenberg's work in forensic genetics has explored the implications of imputation techniques for genetic privacy.[29][30] His work in coalescent theory has characterized the effects of consanguinity,[31] founder events,[32] and migration[33] on patterns of genetic variation. And his work in human genetics has investigated the implications of population history for association studies and polygenic scores.[34][35]

Rosenberg has contributed to the understanding of mathematical properties of objects and quantities used in evolutionary biology. His work includes combinatorial enumeration of phylogenetic trees and coalescent histories,[36][37][38][39] analysis of evolutionary models,[40][41][42] and derivation of mathematical bounds on population-genetic statistics.[43][44][45] He has also applied population-genetic statistics to other fields, such as his 2020 paper bridging health care efficiency research and population-genetic statistics which he co-authored with his wife, Donna Zulman.[46]

Rosenberg is a regular contributor to the On-Line Encyclopedia of Integer Sequences.[47][48][49]

References

  1. ↑ Noah Rosenberg at the Mathematics Genealogy Project
  2. ↑ 2.0 2.1 "People | Center for Computational, Evolutionary and Human Genomics (CEHG)" (in en). https://cehg.stanford.edu/people. 
  3. ↑ University, Stanford (2020-06-01). "Where mathematics and biology meet" (in en). https://news.stanford.edu/2020/06/01/mathematics-biology-meet/. 
  4. ↑ 4.0 4.1 "Theoretical Population Biology Editorial Board". https://www.journals.elsevier.com/theoretical-population-biology/editorial-board/. 
  5. ↑ The Noah Sheets
  6. ↑ 6.0 6.1 "Noah Rosenberg CV". https://rosenberglab.stanford.edu/CV-Rosenberg-2023.pdf. 
  7. ↑ 7.0 7.1 "Noah Rosenberg's Profile | Stanford Profiles". https://profiles.stanford.edu/noah-rosenberg. 
  8. ↑ https://www.proquest.com/dissertations-theses/statistical-modeling-genetic-histories/docview/304727329/se-2?accountid=14026 Statistical modeling of genetic histories and relationships of populations
  9. ↑ 9.0 9.1 Horton, Richard (2003). "Read all about it: The Lancet 's Paper of the Year, 2003". The Lancet 362 (9401): 2101–2103. doi:10.1016/s0140-6736(03)15110-0. ISSN 0140-6736. PMID 14697815. PMC 7123340. https://doi.org/10.1016/S0140-6736(03)15110-0. 
  10. ↑ "Noah Rosenberg | Stanford Institute for Computational & Mathematical Engineering" (in en). https://profiles.stanford.edu/23986. 
  11. ↑ University, © Stanford; Stanford; California 94305 (2014-06-20). "Noah Rosenberg - Professor of Biology" (in en). https://biox.stanford.edu/people/noah-rosenberg. 
  12. ↑ Korte, Andrea (27 November 2018). "AAAS Honors Accomplished Scientists as 2018 Elected Fellows". https://www.aaas.org/news/aaas-honors-accomplished-scientists-2018-elected-fellows. 
  13. ↑ "Jaehee Kim". https://jaeheekimlab.github.io/team/jaehee-kim/. 
  14. ↑ "Amy Goldberg, PhD - People" (in en-US). https://www.goldberglab.org/people. 
  15. ↑ "Scheet Lab". http://scheet.org/paul.html. 
  16. ↑ "Edge Lab - Team". https://edgepopgen.github.io/edgelab/team/. 
  17. ↑ "Mooney Lab". https://mooney-lab.github.io/#. 
  18. ↑ "Editorial Board". https://academic.oup.com/emph/pages/Editorial_Board. 
  19. ↑ "Co-Directors | Center for Computational, Evolutionary and Human Genomics (CEHG)" (in en). https://cehg.stanford.edu/people/co-directors. 
  20. ↑ Prillaman, McKenzie (2021-12-07). "Stanford professor spotlights evolutionary tree concepts with campus trees". https://news.stanford.edu/2021/12/07/stanford-professor-spotlights-evolutionary-tree-concepts-campus-trees/. 
  21. ↑ Brown, David (2008-02-22). "Genetic Mutations Offer Insights on Human Diversity" (in en-US). The Washington Post. ISSN 0190-8286. http://www.washingtonpost.com/wp-dyn/content/article/2008/02/21/AR2008022102739.html. 
  22. ↑ Balter, Michael (2011-09-23). "Tracing the Paths of the First Americans" (in en). Science 333 (6050): 1692. doi:10.1126/science.333.6050.1692. ISSN 0036-8075. https://www.science.org/doi/10.1126/science.333.6050.1692. 
  23. ↑ Hunley, Keith (2015-02-17). "Reassessment of global gene–language coevolution" (in en). Proceedings of the National Academy of Sciences 112 (7): 1919–1920. doi:10.1073/pnas.1425000112. ISSN 0027-8424. PMID 25675520. 
  24. ↑ Rosenberg, Noah A. (2004). "distruct : a program for the graphical display of population structure" (in en). Molecular Ecology Notes 4 (1): 137–138. doi:10.1046/j.1471-8286.2003.00566.x. ISSN 1471-8278. https://onlinelibrary.wiley.com/doi/10.1046/j.1471-8286.2003.00566.x. 
  25. ↑ Kopelman, Naama M.; Mayzel, Jonathan; Jakobsson, Mattias; Rosenberg, Noah A.; Mayrose, Itay (2015). "Clumpak : a program for identifying clustering modes and packaging population structure inferences across K" (in en). Molecular Ecology Resources 15 (5): 1179–1191. doi:10.1111/1755-0998.12387. ISSN 1755-098X. PMID 25684545. 
  26. ↑ Imbler, Sabrina. "New DNA Analysis Supports an Unrecognized Tribe's Ancient Roots in California". The New York Times. https://www.nytimes.com/2022/04/12/science/muwekma-ohlone-tribe-california-dna.html. 
  27. ↑ MacCormick, Holly Alyssa (2023-07-10). "New genealogy method helps fill gaps in African American ancestry" (in en). https://news.stanford.edu/2023/07/10/new-genealogy-method-helps-fill-gaps-african-american-ancestry/. 
  28. ↑ Rosenberg, Noah A.; Weitzman, Steven P. (2013). "From Generation to Generation: The Genetics of Jewish Populations". Human Biology 85 (6): 817–823. ISSN 1534-6617. https://muse.jhu.edu/pub/27/article/548063. 
  29. ↑ Collins, Nathan (2017-05-15). "Gene matches could aid science, but raise privacy concerns" (in en). https://news.stanford.edu/2017/05/15/gene-matches-aid-science-raise-privacy-concerns/. 
  30. ↑ Collins, Nathan (2018-10-17). "New way to find relatives from forensic DNA" (in en). https://news.stanford.edu/2018/10/17/new-way-find-relatives-forensic-dna/. 
  31. ↑ Severson, Alissa L; Carmi, Shai; Rosenberg, Noah A (2019). "The Effect of Consanguinity on Between-Individual Identity-by-Descent Sharing" (in en). Genetics 212 (1): 305–316. doi:10.1534/genetics.119.302136. ISSN 1943-2631. PMID 30926583. 
  32. ↑ DeGiorgio, Michael; Degnan, James H; Rosenberg, Noah A (2011). "Coalescence-Time Distributions in a Serial Founder Model of Human Evolutionary History" (in en). Genetics 189 (2): 579–593. doi:10.1534/genetics.111.129296. ISSN 1943-2631. PMID 21775469. 
  33. ↑ Alcala, Nicolas; Goldberg, Amy; Ramakrishnan, Uma; Rosenberg, Noah A (2019). Heyer, Evelyne. ed. "Coalescent Theory of Migration Network Motifs" (in en). Molecular Biology and Evolution 36 (10): 2358–2374. doi:10.1093/molbev/msz136. ISSN 0737-4038. PMID 31165149. PMC 6759081. https://academic.oup.com/mbe/article/36/10/2358/5511409. 
  34. ↑ Edge, Michael D.; Gorroochurn, Prakash; Rosenberg, Noah A. (2013). "Windfalls and pitfalls" (in en). Evolution, Medicine, and Public Health 2013 (1): 254–272. doi:10.1093/emph/eot021. ISSN 2050-6201. PMID 24481204. 
  35. ↑ Rosenberg, Noah A; Edge, Michael D; Pritchard, Jonathan K; Feldman, Marcus W (2019-01-01). "Interpreting polygenic scores, polygenic adaptation, and human phenotypic differences" (in en). Evolution, Medicine, and Public Health 2019 (1): 26–34. doi:10.1093/emph/eoy036. ISSN 2050-6201. PMID 30838127. PMC 6393779. https://academic.oup.com/emph/article/2019/1/26/5262222. 
  36. ↑ Rosenberg, Noah A. (2007). "Counting Coalescent Histories". Journal of Computational Biology 14 (3): 360–377. doi:10.1089/cmb.2006.0109. https://www.liebertpub.com/doi/abs/10.1089/cmb.2006.0109. 
  37. ↑ Rosenberg, Noah A.; Degnan, James H. (2010). "Coalescent histories for discordant gene trees and species trees". Theoretical Population Biology 77 (3): 145–151. doi:10.1016/j.tpb.2009.12.004. ISSN 0040-5809. https://www.sciencedirect.com/science/article/pii/S0040580909001385. 
  38. ↑ Disanto, Filippo; Rosenberg, Noah A. (2015). "Coalescent Histories for Lodgepole Species Trees" (in en). Journal of Computational Biology 22 (10): 918–929. doi:10.1089/cmb.2015.0015. ISSN 1066-5277. http://www.liebertpub.com/doi/10.1089/cmb.2015.0015. 
  39. ↑ Rosenberg, Noah A. (2019). "Enumeration of lonely pairs of gene trees and species trees by means of antipodal cherries". Advances in Applied Mathematics 102: 1–17. doi:10.1016/j.aam.2018.09.001. ISSN 0196-8858. 
  40. ↑ Rosenberg, Noah A. (2006). "The Mean and Variance of the Numbers of r-Pronged Nodes and r-Caterpillars in Yule-Generated Genealogical Trees" (in en). Annals of Combinatorics 10 (1): 129–146. doi:10.1007/s00026-006-0278-6. ISSN 0219-3094. https://doi.org/10.1007/s00026-006-0278-6. 
  41. ↑ Mehta, Rohan S.; Bryant, David; Rosenberg, Noah A. (2016). "The probability of monophyly of a sample of gene lineages on a species tree" (in en). Proceedings of the National Academy of Sciences 113 (29): 8002–8009. doi:10.1073/pnas.1601074113. ISSN 0027-8424. PMID 27432988. 
  42. ↑ Disanto, Filippo; Fuchs, Michael; Paningbatan, Ariel R.; Rosenberg, Noah A. (2022). "The distributions under two species-tree models of the number of root ancestral configurations for matching gene trees and species trees". The Annals of Applied Probability 32 (6): 4426–4458. doi:10.1214/22-AAP1791. ISSN 1050-5164. 
  43. ↑ Edge, Michael D.; Rosenberg, Noah A. (2014). "Upper bounds on FST in terms of the frequency of the most frequent allele and total homozygosity: The case of a specified number of alleles". Theoretical Population Biology 97: 20–34. doi:10.1016/j.tpb.2014.08.001. ISSN 0040-5809. PMID 25132646. 
  44. ↑ Alcala, Nicolas; Rosenberg, Noah A (2017). "Mathematical Constraints on F ST: Biallelic Markers in Arbitrarily Many Populations" (in en). Genetics 206 (3): 1581–1600. doi:10.1534/genetics.116.199141. ISSN 1943-2631. PMID 28476869. 
  45. ↑ Morrison, Maike L.; Rosenberg, Noah A. (2023). "Mathematical bounds on Shannon entropy given the abundance of the ith most abundant taxon" (in en). Journal of Mathematical Biology 87 (5): 76. doi:10.1007/s00285-023-01997-3. ISSN 0303-6812. PMID 37884812. 
  46. ↑ Armitage, Hanae (2020-02-13). "Formula for an "aha" moment: Pair up with your spouse" (in en-US). https://scopeblog.stanford.edu/2020/02/13/formula-for-an-aha-moment-pair-up-with-your-spouse/. 
  47. ↑ "A354690 - OEIS". https://oeis.org/A354690. 
  48. ↑ "A355108 - OEIS". https://oeis.org/A355108. 
  49. ↑ "A354970 - OEIS". https://oeis.org/A354970. 

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