Biography:Xiaoliang Sunney Xie
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Short description: Chinese-American biochemist
Xiaoliang Sunney Xie | |
|---|---|
 | |
| Born | June 24, 1962 Beijing, China |
| Education | BSc in chemistry from Peking University PhD in Physical Chemistry from UC San Diego |
| Known for | Single Molecule Enzymology, Coherent Raman Imaging, Single Cell Genomics |
| Awards | Albany Prize in Medicine and Biomedical Research 2015, Peter Debye Award in Physical Chemistry 2015, Ellis R. Lippincott Award 2013, Biophysical Society Founders Award 2012 NAS 2011 NAM 2016 CAS 2017 |
| Scientific career | |
| Fields | Biophysical Chemistry, Optical Imaging, Genomics |
| Institutions | Harvard University Peking University |
| Doctoral advisor | John Douglas Simon[1] |
Xiaoliang Sunney Xie (Chinese: 谢晓亮; born 24 June 1962) is a Chinese biophysicist well known for his contributions to the fields of single-molecule biophysical chemistry, coherent Raman Imaging and single-molecule genomics. In 2023, Xie renounced his U.S. citizenship in order to reclaim his Chinese citizenship.[2]
Early life
Xie was born in Beijing in 1962 with ancestral roots in Hepu County, Guangxi. He received his B.Sc. in chemistry from Peking University in 1984, and his Ph.D. in physical chemistry in 1990 from University of California at San Diego. After a brief postdoctoral appointment at University of Chicago, he joined Pacific Northwest National Laboratory, where he rose from senior research scientist to chief scientist. In 1998, he became the first tenured professor recruited by Harvard University among Chinese scholars who came to the United States since Chinese economic reform.
Research
He had been the Mallinckrodt Professor of Chemistry and Chemical Biology at Harvard University until 2018, when he became the Lee Shau-kee Professor of Peking University. He was the Director of Biomedical Pioneering Innovation Center (BIOPIC) in 2010-2021, and the Director of Beijing Advanced Innovation Center for Genomics (ICG) in 2016-2021, both at Peking University.
As a pioneer of single-molecule biophysical chemistry, Coherent Raman scattering microscopy, and single-cell genomics, he made major contributions to the emergence of these fields. Furthermore, he has made significant advances on medical applications of label-free optical imaging and single-cell genomics. In particular, his inventions in single-cell genomics have been used in in vitro fertilization benefited thousands of families by avoiding the transmission of monogenic diseases to their newborns.
More than fifty of his students and post-doctorates have become professors at major universities around the world, and two are co-founders of start-up companies. Professor Xie’s current research interests include the following scientific, technological, and medical areas:
- Scientific: Single-molecule enzymology, Single-molecule biophysical chemistry, Gene expression and regulation, Epigenetics, Mechanism of cell differentiation and reprogramming, Chromosome structure and dynamics, and Genomic instability;
- Technological: Single-molecule imaging, Single-cell genomics, Coherent Raman scattering microscopy, DNA sequencing;
- Medical: Preimplantation genetic testing in in vitro fertilization, COVID19 vaccine and neutralizing antibody drugs for SARS-CoV-2 variants and Early cancer diagnosis.
Honors and awards
- 2017: Qiu Shi Outstanding Scientist Award, Qiu Shi Science & Technologies Foundation[3]
- 2017: Foreign member of the Chinese Academy of Sciences[4] (As of 2023, member of the CAS after Chinese citizenship reclaimed)
- 2016: Member of the National Academy of Medicine[5]
- 2015: Albany Medical Center Prize[6]
- 2015: Peter Debye Award in Physical Chemistry, American Chemical Society[7]
- 2014: Fellow of the Optical Society of America
- 2013: NIH Director's Pioneer Award[8]
- 2013: Ellis R. Lippincott Award, Optical Society of America and Society for Applied Spectroscopy[9]
- 2012: Edward Mack, Jr. Lecture, OSU
- 2012: Harrison Howe Award, Rochester Section of the American Chemical Society
- 2012: Fellow of the American Academy of Microbiology
- 2012: Biophysical Society Founders Award
- 2011: Member of the National Academy of Sciences
- 2009: Ernest Orlando Lawrence Award
- 2008: Fellow of the American Physical Society
- 2008: Berthold Leibinger Zukunftspreis for Applied Laser Technology[10]
- 2008: Fellow of the American Academy of Arts and Sciences
- 2007: Willis E. Lamb Award for Laser Sciences and Quantum Optics[11]
- 2006: Fellow of Biophysical Society
- 2006: Fellow of the American Association for the Advancement of Science
- 2004: NIH Director's Pioneer Award[12]
- 2003: Raymond and Beverly Sackler Prize in the Physical Sciences
- 1996: Coblentz Award
Selected Literature
COVID-19 Research
- Du, Shuo; Liu, Pulan; Zhang, Zhiying; Xiao, Tianhe; Yasimayi, Ayijiang; Huang, Weijin; Wang, Youchun; Cao, Yunlong et al. (25 August 2021). "Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants". Cell Research (Springer Science and Business Media LLC) 31 (10): 1130–1133. doi:10.1038/s41422-021-00555-0. ISSN 1001-0602. PMID 34433900.
- Cao, Yunlong; Wang, Jing; Jian, Fanchong; Xiao, Tianhe; Song, Weiliang; Yisimayi, Ayijiang; Huang, Weijin; Li, Qianqian et al. (23 December 2021). "Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies". Nature (Springer Science and Business Media LLC) 602 (7898): 657–663. doi:10.1038/s41586-021-04385-3. ISSN 0028-0836. PMID 35016194.
- Cao, Yunlong; Yisimayi, Ayijiang; Bai, Yali; Huang, Weijin; Li, Xiaofeng; Zhang, Zhiying; Yuan, Tianjiao; An, Ran et al. (21 May 2021). "Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines". Cell Research (Springer Science and Business Media LLC) 31 (7): 732–741. doi:10.1038/s41422-021-00514-9. ISSN 1001-0602. PMID 34021265.
- Du, Shuo; Cao, Yunlong; Zhu, Qinyu; Yu, Pin; Qi, Feifei; Wang, Guopeng; Du, Xiaoxia; Bao, Linlin et al. (2020). "Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy". Cell (Elsevier BV) 183 (4): 1013–1023.e13. doi:10.1016/j.cell.2020.09.035. ISSN 0092-8674. PMID 32970990.
- Cao, Yunlong; Su, Bin; Guo, Xianghua; Sun, Wenjie; Deng, Yongqiang; Bao, Linlin; Zhu, Qinyu; Zhang, Xu et al. (2020). "Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells". Cell (Elsevier BV) 182 (1): 73–84.e16. doi:10.1016/j.cell.2020.05.025. ISSN 0092-8674. PMID 32425270.
Single-Cell Genomics
- Tan, Longzhi; Xie, X. Sunney (2018). "A Near-complete Spatial Map of Olfactory Receptors in the Mouse Main Olfactory Epithelium". Chem Senses 43 (6): 427–432. doi:10.1093/chemse/bjy030. PMID 29796642.
- Xu, Juanjuan; Fang, Rui; Chen, Li; Chen, Daozhen; Xiao, Jian-Ping; Yang, Weimin; Wang, Honghua; Song, Xiaoqing et al. (2016). "Noninvasive chromosome screening of human embryos by genome sequencing of embryo culture medium for in vitro fertilization". Proc Natl Acad Sci USA 113 (42): 11907–1. doi:10.1073/pnas.1613294113. PMID 27688762. Bibcode: 2016PNAS..11311907X.
- Chen, Chongyi; Xing, Dong; Tan, Longzhi; Li, Heng; Zhou, Guangyu; Huang, Lei; Xie, X. Sunney (2017). "Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)". Science 356 (6334): 189–194. doi:10.1126/science.aak9787. PMID 28408603. Bibcode: 2017Sci...356..189C.
- Yan, Liying; Huang, Lei; Xu, Liya; Huang, Jin; Ma, Fei; Zhu, Xiaohui; Tang, Yaqiong; Liu, Mingshan et al. (2015). "Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses". Proc Natl Acad Sci USA 112 (52): 15964–15969. doi:10.1073/pnas.1523297113. PMID 26712022. Bibcode: 2015PNAS..11215964Y.
- Hou, Yu; Fan, Wei; Yan, Liying; Li, Rong; Lian, Ying; Huang, Jin; Li, Jinsen; Xu, Liya et al. (2013). "Genome Analyses of Single Human Oocytes". Cell 155 (7): 1492–1506. doi:10.1016/j.cell.2013.11.040. PMID 24360273.
- Zong, Chenghang; Lu, Sijia; Chapman, Alec R.; Xie, X. Sunney (2012). "Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell". Science 338 (6114): 1622–1626. doi:10.1126/science.1229164. PMID 23258894. Bibcode: 2012Sci...338.1622Z.
Gene Expression and Regulation
- Chong, Shasha; Chen, Chongyi; Ge, Hao; Sunney, Xie X. (2014). "Mechanism of Transcriptional Bursting in Bacteria". Cell 158 (2): 314–326. doi:10.1016/j.cell.2014.05.038. PMID 25036631.
- Taniguchi, Yuichi; Choi, Paul J.; Li, Gene-Wei; Chen, Huiyi; Babu, Mohan; Hearn, Jeremy; Emili, Andrew; Xie, X. Sunney (2010). "Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells". Science 329 (5991): 533–538. doi:10.1126/science.1188308. PMID 20671182. Bibcode: 2010Sci...329..533T.
- Choi, Paul J.; Cai, Long; Frieda, Kirsten; Xie, X. Sunney (2008). "A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell". Science 322 (5900): 442–446. doi:10.1126/science.1161427. PMID 18927393. Bibcode: 2008Sci...322..442C.
- Elf, Johan; Li, Gene-Wei; Xie, X. Sunney (2007). "Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell". Science 316 (5828): 1191–1194. doi:10.1126/science.1141967. PMID 17525339. Bibcode: 2007Sci...316.1191E.
- Yu, Ji; Xiao, Jie; Ren, Xiaojia; Lao, Kaiqin; Xie, X. Sunney (2006). "Probing Gene Expression in Live Cells, One Protein Molecule at a Time". Science 311 (5767): 1600–1603. doi:10.1126/science.1119623. PMID 16543458. Bibcode: 2006Sci...311.1600Y.
- Cai, Long; Friedman, Nir; Xie, X. Sunney (2006). "Stochastic Protein Expression in Individual Cells at the Single Molecule Level". Nature 440 (7082): 358–362. doi:10.1038/nature04599. PMID 16541077. Bibcode: 2006Natur.440..358C.
Single Molecule Enzymology
- Chong, Shasha; Chen, Chongyi; Ge, Hao; Sunney, Xie X. (2014). "Mechanism of Transcriptional Bursting in Bacteria". Cell 158 (2): 314–326. doi:10.1016/j.cell.2014.05.038. PMID 25036631.
- Kim, Sangjin; Broströmer, Erik; Xing, Dong; Jin, Jianshi; Chong, Shasha; Ge, Hao; Wang, Siyuan; Gu, Chan et al. (2013). "Probing Allostery Through DNA". Science 339 (6121): 816–819. doi:10.1126/science.1229223. PMID 23413354. Bibcode: 2013Sci...339..816K.
- English, Brian P.; Min, Wei; van Oijen, Antoine M.; Lee, Kang Taek; Luo, Guobin; Sun, Hongye; Cherayil, Binny J.; Kou, S.C. et al. (2006). "Ever-Fluctuating Single Enzyme Molecules: Michaelis-Menten Equation Revisited". Nat Chem Biol 2 (2): 87–94. doi:10.1038/nchembio759. PMID 16415859.
- Yang, Haw; Luo, Guobin; Karnchanaphanurach, Pallop; Louie, Tai-Man; Rech, Ivan; Cova, Sergio; Xun, Luying; Xie, X. Sunney (2003). "Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer". Science 302 (5643): 262–266. doi:10.1126/science.1086911. PMID 14551431. Bibcode: 2003Sci...302..262Y.
- Lu, H. Peter; Xun, Luying; Xie, X. Sunney (1998). "Single-Molecule Enzymatic Dynamics". Science 282 (5395): 1877–1882. doi:10.1126/science.282.5395.1877. PMID 9836635. Bibcode: 1998Sci...282.1877P.
Coherent Raman Imaging
- Ji, Minbiao; Orringer, Daniel A.; Freudiger, Christian W.; Ramkissoon, Shakti; Liu, Xiaohui; Lau, Darryl; Golby, Alexandra J.; Norton, Isaiah et al. (2013). "Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy". Science Translational Medicine 5 (201): 201. doi:10.1126/scitranslmed.3005954. PMID 24005159.
- Wang, Meng C.; Min, Wei; Freudiger, Christian W.; Ruvkun, Gary; Xie, X. Sunney (2011). "RNAi Screening for Fat Regulatory Genes with SRS Microscopy". Nat Methods 8 (2): 135–138. doi:10.1038/nmeth.1556. PMID 21240281.
- Saar, Brian G.; Freudiger, Christian W.; Reichman, Jay; Stanley, C. Michael; Holtom, Gary R.; Xie, X. Sunney (2010). "Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering". Science 330 (6009): 1368–1370. doi:10.1126/science.1197236. PMID 21127249. Bibcode: 2010Sci...330.1368S.
- Freudiger, Christian W.; Min, Wei; Saar, Brian G.; Lu, Sijia; Holtom, Gary R.; He, Chengwei; Tsai, Jason C.; Kang, Jing X. et al. (2008). "Label-Free Biomedical Imaging with High sensitivity by Stimulated Raman Scattering Microscopy". Science 322 (5909): 1857–1860. doi:10.1126/science.1165758. PMID 19095943. Bibcode: 2008Sci...322.1857F.
- Evans, Conor L.; Potma, Eric O.; Puoris'Haag, Mehron; Côté, Daniel; Lin, Charles P.; Xie, X. Sunney (2005). "Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy". Proc. Natl. Acad. Sci. 102 (46): 16807–16812. doi:10.1073/pnas.0508282102. PMID 16263923. Bibcode: 2005PNAS..10216807E.
- Zumbusch, Andreas; Holtom, Gary R.; Xie, X. Sunney (1999). "Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering". Phys Rev Lett 82 (20): 4142–4145. doi:10.1103/physrevlett.82.4142. Bibcode: 1999PhRvL..82.4142Z.
Single Molecule Imaging
- Zhou, Yuexin; Wang, Ping; Tian, Feng; Gao, Ge; Huang, Lei; Wei, Wensheng; Xie, X. Sunney (2017). "Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging". Cell Res 27 (2): 298–301. doi:10.1038/cr.2017.9. PMID 28084328.
- Chong, Shasha; Min, Wei; Xie, X. Sunney (2010). "Ground-State Depletion Microscopy:Detection Sensitivity of Single-Molecule Optical Absorption at Room Temperature". J Phys Chem Lett 1 (23): 3316–3322. doi:10.1021/jz1014289. https://resolver.caltech.edu/CaltechAUTHORS:20210902-233957747.
- Min, Wei; Lu, Sijia; Chong, Shasha; Roy, Rahul; Holtom, Gary R.; Xie, X. Sunney (2009). "Imaging Chromophores with Undetectable Fluorescence by Stimulated Emission Microscopy". Nature 461 (7267): 1105–1109. doi:10.1038/nature08438. PMID 19847261. Bibcode: 2009Natur.461.1105M. http://nrs.harvard.edu/urn-3:HUL.InstRepos:3693471.
- Sánchez, Erik J.; Novotny, Lukas; Xie, X. Sunney (1999). "Near-field Fluorescence Microscopy Based on Two-photon Excitation with Metal Tips". Phys Rev Lett 82 (20): 4014–4017. doi:10.1103/physrevlett.82.4014. Bibcode: 1999PhRvL..82.4014S. https://pdxscholar.library.pdx.edu/phy_fac/51.
- Sánchez, Erik J.; Novotny, Lukas; Holtom, G.R.; Xie, X. Sunney (1997). "Room-Temperature Fluorescence Imaging and Spectroscopy of Single Molecules by Two-Photon Excitation". J Phys Chem A 101 (38): 7019–7023. doi:10.1021/jp971915b. Bibcode: 1997JPCA..101.7019S.
- Xie, X. Sunney; Dunn, Robert C. (1994). "Probing Single Molecule Dynamics". Science 265 (5170): 361–364. doi:10.1126/science.265.5170.361. PMID 17838036. Bibcode: 1994Sci...265..361X.
See also
References
- ↑ "About Professor Xie". https://bernstein.harvard.edu/pages/AboutProfXie.html.
- ↑ "Xie Xiaoliang is latest Chinese scientist to give up US citizenship". South China Morning Post. 9 June 2023. https://www.scmp.com/news/china/science/article/3223515/xie-xiaoliang-latest-chinese-scientist-give-us-citizenship.
- ↑ "PKU Professor Xiaoliang Sunney Xie awarded Qiu Shi Outstanding Scientist Award of 2017". http://newsen.pku.edu.cn/news_events/news/focus/6288.htm.
- ↑ "关于公布2017年中国科学院院士增选当选院士名单的公告" (in zh). Chinese Academy of Sciences. 2017-11-28. http://www.cas.cn/tt/201711/t20171128_4624789.shtml.
- ↑ "National Academy of Medicine Elects 79 New Members". https://nam.edu/national-academy-of-medicine-elects-79-new-members/.
- ↑ "Albany Medical Center Prize". http://www.amc.edu/Academic/AlbanyPrize/Recipients/recipients_current/xie.cfm.
- ↑ "Peter Debye Award". https://www.acs.org/content/acs/en/funding-and-awards/awards/national/bytopic/peter-debye-award-in-physical-chemistry.html.
- ↑ "NIH Director's Pioneer Award 2013". https://commonfund.nih.gov/pioneer/Recipients13.
- ↑ "Ellis R. Lippincott Award". http://www.osa.org/en-us/awards_and_grants/awards/award_description/ellislippincott/.
- ↑ "Berthold Leibinger Zukunftspreis". http://www.leibinger-stiftung.de/de/foerderaktivitaeten/laser-forschungs-innovationspreis/zukunftspreis.html.
- ↑ "Biography of Xie from the Website of the Willis E. Lamb Award (displayed June 4, 2008)". http://www.lambmedal.org/2007/2007-xie.html.
- ↑ "NIH Director's Pioneer Award 2004". https://commonfund.nih.gov/pioneer/Recipients04.
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