Biology:(R)-dehydropantoate dehydrogenase
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Short description: Class of enzymes
(R)-dehydropantoate dehydrogenase | |||||||||
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Identifiers | |||||||||
EC number | 1.2.1.33 | ||||||||
CAS number | 37250-96-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a (R)-dehydropantoate dehydrogenase (EC 1.2.1.33) is an enzyme that catalyzes the chemical reaction
- (R)-4-dehydropantoate + NAD+ + H2O [math]\displaystyle{ \rightleftharpoons }[/math] (R)-3,3-dimethylmalate + NADH + 2 H+
The 3 substrates of this enzyme are (R)-4-dehydropantoate, NAD+, and H2O, whereas its 3 products are (R)-3,3-dimethylmalate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-4-dehydropantoate:NAD+ 4-oxidoreductase. Other names in common use include D-aldopantoate dehydrogenase, D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine, and nucleotide (DPN+) oxidoreductase. This enzyme participates in pantothenate and coa biosynthesis.
References
- "The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to alpha-ketoisovalerate". Biochemistry 5 (2): 409–16. 1966. doi:10.1021/bi00866a004. PMID 4287371.
![]() | Original source: https://en.wikipedia.org/wiki/(R)-dehydropantoate dehydrogenase.
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