Biology:(tyrosine 3-monooxygenase) kinase

From HandWiki
Short description: Class of enzymes
[tyrosine 3-monooxygenase] kinase
Identifiers
EC number2.7.11.6
CAS number103537-12-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a [tyrosine 3-monooxygenase] kinase (EC 2.7.11.6) is an enzyme that catalyzes the chemical reaction

ATP + [tyrosine-3-monooxygenase] [math]\displaystyle{ \rightleftharpoons }[/math] ADP + phospho-[tyrosine-3-monooxygenase]

Thus, the two substrates of this enzyme are ATP and tyrosine 3-monooxygenase, whereas its two products are ADP and phospho-(tyrosine-3-monooxygenase).

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[tyrosine-3-monoxygenase] phosphotransferase. Other names in common use include pheochromocytoma tyrosine hydroxylase-associated kinase, STK4, and tyrosine 3-monooxygenase kinase (phosphorylating). This enzyme participates in MAPK signaling pathway and non-small cell lung cancer.

References

  • "[Copurification of tyrosine hydroxylase from rat pheochromocytoma by protein kinase]". Comptes Rendus de l'Académie des Sciences, Série III 302 (12): 435–8. 1986. PMID 2872947. 
  • "Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase". J. Biol. Chem. 262 (13): 6155–8. 1987. PMID 2883182.