Biology:2-haloacid dehalogenase (configuration-inverting)
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Short description: Class of enzymes
| 2-haloacid dehalogenase (configuration-inverting) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.8.1.10 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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2-haloacid dehalogenase (configuration-inverting) (EC 3.8.1.10, 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, DL-2-haloacid dehalogenase, DL-2-haloacid dehalogenase (inversion of configuration), DL-2-haloacid halidohydrolase (inversion of configuration), DL-DEXi, (R,S)-2-haloacid dehalogenase (configuration-inverting)) is an enzyme with systematic name (S)-2-haloacid dehalogenase (configuration-inverting).[1][2][3][4][5][6][7][8][9] This enzyme catalyses the following chemical reaction
- (1) (S)-2-haloacid + H2O [math]\displaystyle{ \rightleftharpoons }[/math] (R)-2-hydroxyacid + halide
- (2) (R)-2-haloacid + H2O [math]\displaystyle{ \rightleftharpoons }[/math] (S)-2-hydroxyacid + halide
This enzyme dehalogenates both (S)- and (R)-2-haloalkanoic acids.
References
- ↑ "Bacterial assimilation of D- and L-2-chloropropionates and occurrence of a new dehalogenase". Archives of Microbiology 131 (3): 179–83. May 1982. doi:10.1007/BF00405875. PMID 7103659.
- ↑ "Purification and properties of a new enzyme, DL-2-haloacid dehalogenase, from Pseudomonas sp". Journal of Bacteriology 150 (2): 522–7. May 1982. PMID 7068529.
- ↑ "Enzymatic preparation of D- and L-lactic acid from racemic 2-chloropropionic acid". Biotechnology and Bioengineering 26 (7): 805–6. July 1984. doi:10.1002/bit.260260729. PMID 18553452.
- ↑ "Bacterial 2-haloacid dehalogenases: structures and reaction mechanisms". J. Mol. Catal., B Enzym. 10 (1–3): 57–65. 2000. doi:10.1016/S1381-1177(00)00108-9.
- ↑ "Purification and characterization of thermostable and nonthermostable 2-haloacid dehalogenases with different stereospecificities from Pseudomonas sp. strain YL". Applied and Environmental Microbiology 60 (7): 2389–93. July 1994. PMID 8074519.
- ↑ "Cloning, sequencing and expression in Escherichia coli of two Rhizobium sp. genes encoding haloalkanoate dehalogenases of opposite stereospecificity". European Journal of Biochemistry 235 (3): 744–9. February 1996. doi:10.1111/j.1432-1033.1996.t01-1-00744.x. PMID 8654424.
- ↑ "Partial purification, stereospecificity and stoichiometry of three dehalogenases from a Rhizobium species". FEMS Microbiol. Lett. 49 (3): 353–356. 1988. doi:10.1111/j.1574-6968.1988.tb02756.x.
- ↑ "Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas putida PP3: evidence for two different dehalogenation mechanisms". Journal of General Microbiology 128 (8): 1755–62. August 1982. doi:10.1099/00221287-128-8-1755. PMID 7142958.
- ↑ "Bacterial 2-haloacid dehalogenases: Structures and catalytic properties". Pure Appl. Chem. 68 (11): 2097–2103. 1996. doi:10.1351/pac199668112097.
External links
- 2-haloacid+dehalogenase+(configuration-inverting) at the US National Library of Medicine Medical Subject Headings (MeSH)
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