Biology:2-hydroxy-6-oxonona-2,4-dienedioate hydrolase

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2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
EC number3.7.1.14
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

2-hydroxy-6-oxonona-2,4-dienedioate hydrolase (EC, mhpC (gene)) is an enzyme with systematic name (2Z,4E)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction:

  1. (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H2O [math]\rightleftharpoons[/math] (2Z)-2-hydroxypenta-2,4-dienoate + succinate
  2. (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H2O [math]\rightleftharpoons[/math] (2Z)-2-hydroxypenta-2,4-dienoate + fumarate

This enzyme catalyses a step in a pathway of phenylpropanoid compounds degradation.


  1. "Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli". Journal of Bacteriology 155 (1): 113–21. July 1983. PMID 6345502. 
  2. "Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation". Journal of Bacteriology 168 (1): 55–64. October 1986. PMID 3531186. 
  3. "Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic cleavage". J. Chem. Soc., Chem. Commun. 10 (10): 1163–1164. 1994. doi:10.1039/c39940001163. 
  4. "Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase". Biochemistry 36 (40): 12242–51. October 1997. doi:10.1021/bi971115r. PMID 9315862. 
  5. "Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12". Journal of Bacteriology 179 (8): 2573–81. April 1997. PMID 9098055. 
  6. "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12". Journal of Bacteriology 180 (11): 2915–23. June 1998. PMID 9603882. 

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