Biology:2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
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Short description: Class of enzymes
| 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.7.1.14 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
2-hydroxy-6-oxonona-2,4-dienedioate hydrolase (EC 3.7.1.14, mhpC (gene)) is an enzyme with systematic name (2Z,4E)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction:
- (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] (2Z)-2-hydroxypenta-2,4-dienoate + succinate
- (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] (2Z)-2-hydroxypenta-2,4-dienoate + fumarate
This enzyme catalyses a step in a pathway of phenylpropanoid compounds degradation.
References
- ↑ "Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli". Journal of Bacteriology 155 (1): 113–21. July 1983. PMID 6345502.
- ↑ "Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation". Journal of Bacteriology 168 (1): 55–64. October 1986. PMID 3531186.
- ↑ "Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic cleavage". J. Chem. Soc., Chem. Commun. 10 (10): 1163–1164. 1994. doi:10.1039/c39940001163.
- ↑ "Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase". Biochemistry 36 (40): 12242–51. October 1997. doi:10.1021/bi971115r. PMID 9315862.
- ↑ "Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12". Journal of Bacteriology 179 (8): 2573–81. April 1997. PMID 9098055.
- ↑ "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12". Journal of Bacteriology 180 (11): 2915–23. June 1998. PMID 9603882.
External links
- 2-hydroxy-6-oxonona-2,4-dienedioate+hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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