Biology:6-oxocamphor hydrolase

From HandWiki
Jump to: navigation, search
6-oxocamphor hydrolase
EC number3.7.1.18
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

6-oxocamphor hydrolase (EC, OCH, camK (gene)) is an enzyme with systematic name bornane-2,6-dione hydrolase.[1][2][3] This enzyme catalyses the following chemical reaction

bornane-2,6-dione + H2O [math]\rightleftharpoons[/math] [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate

This enzyme is isolated from Rhodococcus sp.


  1. "The desymmetrization of bicyclic beta -diketones by an enzymatic retro-Claisen reaction. A new reaction of the crotonase superfamily". The Journal of Biological Chemistry 276 (16): 12565–72. April 2001. doi:10.1074/jbc.M011538200. PMID 11278926. 
  2. "The 2-A crystal structure of 6-oxo camphor hydrolase. New structural diversity in the crotonase superfamily". The Journal of Biological Chemistry 278 (3): 1744–50. January 2003. doi:10.1074/jbc.M211188200. PMID 12421807. 
  3. "Structure of 6-oxo camphor hydrolase H122A mutant bound to its natural product, (2S,4S)-alpha-campholinic acid: mutant structure suggests an atypical mode of transition state binding for a crotonase homolog". The Journal of Biological Chemistry 279 (30): 31312–7. July 2004. doi:10.1074/jbc.M403514200. PMID 15138275. 

External links

Grammarly Check DataMelt statistical framewwork for data scientists HandWiki ads