Biology:ABLIM1
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Actin binding LIM protein 1, also known as ABLIM1, is a protein which in humans is encoded by the ABLIM1 gene.[1][2]
Function
This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]
Interactions
ABLIM1 has been shown to interact with LDOC1.[3]
References
- ↑ 1.0 1.1 "Entrez Gene: ABLIM1 actin binding LIM protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3983.
- ↑ "Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein". The Journal of Cell Biology 138 (3): 575–88. August 1997. doi:10.1083/jcb.138.3.575. PMID 9245787.
- ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514.
External links
- Human ABLIM1 genome location and ABLIM1 gene details page in the UCSC Genome Browser.
Further reading
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research 9 (3): 99–106. June 2002. doi:10.1093/dnares/9.3.99. PMID 12168954.
- "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature 377 (6547 Suppl): 3–174. September 1995. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf.
- "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research 1 (5): 223–9. 1995. doi:10.1093/dnares/1.5.223. PMID 7584044.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. September 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein". The Journal of Cell Biology 138 (3): 575–88. August 1997. doi:10.1083/jcb.138.3.575. PMID 9245787.
- "Limatin (LIMAB1), an actin-binding LIM protein, maps to mouse chromosome 19 and human chromosome 10q25, a region frequently deleted in human cancers". Genomics 46 (2): 291–3. December 1997. doi:10.1006/geno.1997.5029. PMID 9417918.
- "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". The Journal of Biological Chemistry 279 (21): 22331–46. May 2004. doi:10.1074/jbc.M400285200. PMID 15024025.
- "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry 76 (10): 2763–72. May 2004. doi:10.1021/ac035352d. PMID 15144186.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. August 2004. doi:10.1073/pnas.0404720101. PMID 15302935.
- "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology 14 (16): 1436–50. August 2004. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- "Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites". Rapid Communications in Mass Spectrometry 19 (1): 57–71. 2005. doi:10.1002/rcm.1746. PMID 15570572.
- "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology 23 (1): 94–101. January 2005. doi:10.1038/nbt1046. PMID 15592455.
- "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics 4 (6): 785–95. June 2005. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nature Methods 2 (8): 591–8. August 2005. doi:10.1038/nmeth776. PMID 16094384.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. November 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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