Biology:LDOC1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Protein LDOC1 is a protein that in humans is encoded by the LDOC1 gene.[1][2][3][4]
Function
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.[4]
Interactions
LDOC1 has been shown to interact with ABLIM1.[5]
References
- ↑ "Identification of a novel gene, LDOC1, down-regulated in cancer cell lines". Cancer Letters 140 (1–2): 227–34. Jun 1999. doi:10.1016/S0304-3835(99)00087-7. PMID 10403563.
- ↑ "Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals". Gene 345 (1): 101–11. Jan 2005. doi:10.1016/j.gene.2004.11.022. PMID 15716091.
- ↑ "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes". Cytogenetic and Genome Research 110 (1–4): 307–17. Aug 2005. doi:10.1159/000084963. PMID 16093683.
- ↑ 4.0 4.1 "Entrez Gene: LDOC1 leucine zipper, down-regulated in cancer 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23641.
- ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
Further reading
- "Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis". International Journal of Cancer 105 (4): 454–8. Jul 2003. doi:10.1002/ijc.11122. PMID 12712434.
- "Protein partners of C/EBPepsilon". Experimental Hematology 32 (12): 1173–81. Dec 2004. doi:10.1016/j.exphem.2004.08.014. PMID 15588942.
- "LDOC1, a novel MZF-1-interacting protein, induces apoptosis". FEBS Letters 579 (3): 604–8. Jan 2005. doi:10.1016/j.febslet.2004.12.030. PMID 15670815.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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