Biology:ACBD3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Golgi resident protein GCP60 is a protein that in humans is encoded by the ACBD3 gene.[1]
Function
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. ACBD3 is involved in maintaining the Golgi structure by interacting with giantin, which affects the transport of protein.[2] The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation.[1]
Interactions
ACBD3 has been shown to interact with GOLGB1.[3]
References
- ↑ 1.0 1.1 "Entrez Gene: ACBD3 acyl-Coenzyme A binding domain containing 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64746.
- ↑ "ACBD3 - Golgi resident protein GCP60 - Homo sapiens (Human) - ACBD3 gene & protein". https://www.uniprot.org/uniprot/Q9H3P7.
- ↑ "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. November 2001. doi:10.1074/jbc.M108961200. PMID 11590181.
External links
- Human ACBD3 genome location and ACBD3 gene details page in the UCSC Genome Browser.
Further reading
- "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin.". J. Biol. Chem. 276 (48): 45298–306. 2002. doi:10.1074/jbc.M108961200. PMID 11590181.
- "Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein.". Mol. Endocrinol. 15 (12): 2211–28. 2002. doi:10.1210/mend.15.12.0736. PMID 11731621.
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. 2004. doi:10.1038/nbt810. PMID 12665801.
- "Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues". FASEB J. 17 (9): 1189–91. 2003. doi:10.1096/fj.02-1066fje. PMID 12692076.
- "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "GCP60 preferentially interacts with a caspase-generated golgin-160 fragment". J. Biol. Chem. 281 (38): 27924–31. 2006. doi:10.1074/jbc.M603276200. PMID 16870622.
- "Identification of a redox-sensitive cysteine in GCP60 that regulates its interaction with golgin-160". J. Biol. Chem. 282 (41): 29874–81. 2007. doi:10.1074/jbc.M705794200. PMID 17711851.
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