Biology:ACSBG1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Acyl-CoA Synthetase, Bubblegum Family, member 1 (ACSBG1) is an enzyme that in humans is encoded by the ACSBG1 gene.[1][2][3]
The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis.[3] The conversion of long chain fatty acids into long chain acyl-CoAs in mice is catalysed by ACSBG1.[4]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. Dec 1998. doi:10.1093/dnares/5.3.169. PMID 9734811.
- ↑ "Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids". J Biol Chem 275 (45): 35162–9. Nov 2000. doi:10.1074/jbc.M006403200. PMID 10954726.
- ↑ 3.0 3.1 "Entrez Gene: ACSBG1 acyl-CoA synthetase bubblegum family member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23205.
- ↑ "Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues.". Biochem Biophys Res Commun 279 (1): 62–8. Dec 2000. doi:10.1006/bbrc.2000.3897. PMID 11112418.
External links
- Human ACSBG1 genome location and ACSBG1 gene details page in the UCSC Genome Browser.
Further reading
- "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues.". Biochem. Biophys. Res. Commun. 279 (1): 62–8. 2001. doi:10.1006/bbrc.2000.3897. PMID 11112418.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation..". J. Biol. Chem. 278 (47): 47070–8. 2004. doi:10.1074/jbc.M310075200. PMID 12975357.
- "Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase.". Biochem. J. 377 (Pt 1): 85–93. 2004. doi:10.1042/BJ20031062. PMID 14516277.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy.". Hum. Mol. Genet. 14 (10): 1293–303. 2005. doi:10.1093/hmg/ddi140. PMID 15800013.
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