Biology:ACTR3B
From HandWiki
Short description: Gene of the species Homo sapiens
![]() Generic protein structure example |
Actin-related protein 3B also known as ARP3-beta is a protein that in humans is encoded by the ACTR3B gene.[1] Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms.[1]
Function
This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility.[1]
References
External links
- Human ACTR3B genome location and ACTR3B gene details page in the UCSC Genome Browser.
Further reading
- "The Arp2/3 complex: a multifunctional actin organizer". Current Opinion in Cell Biology 11 (1): 117–21. Feb 1999. doi:10.1016/S0955-0674(99)80014-3. PMID 10047519.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells". Biochemical and Biophysical Research Communications 312 (4): 889–96. Dec 2003. doi:10.1016/j.bbrc.2003.10.200. PMID 14651955.
- "Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma". Biochemical and Biophysical Research Communications 280 (1): 61–7. Jan 2001. doi:10.1006/bbrc.2000.4059. PMID 11162478.
- "ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells". European Journal of Biochemistry 267 (10): 2921–8. May 2000. doi:10.1046/j.1432-1327.2000.01306.x. PMID 10806390.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
![]() | Original source: https://en.wikipedia.org/wiki/ACTR3B.
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