Biology:ACTR3B

Short description: Gene of the species Homo sapiens

Actin-related protein 3B also known as ARP3-beta is a protein that in humans is encoded by the ACTR3B gene.^[1] Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms.^[1]

Function

This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility.^[1]

References

↑ ^1.0 ^1.1 ^1.2 "Entrez Gene: ACTR3B ARP3 actin-related protein 3 homolog B (yeast)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57180.

External links

Human ACTR3B genome location and ACTR3B gene details page in the UCSC Genome Browser.

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"Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
"Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells". Biochemical and Biophysical Research Communications 312 (4): 889–96. Dec 2003. doi:10.1016/j.bbrc.2003.10.200. PMID 14651955.
"Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma". Biochemical and Biophysical Research Communications 280 (1): 61–7. Jan 2001. doi:10.1006/bbrc.2000.4059. PMID 11162478.
"ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells". European Journal of Biochemistry 267 (10): 2921–8. May 2000. doi:10.1046/j.1432-1327.2000.01306.x. PMID 10806390.