Biology:AGTRAP
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 Generic protein structure example |
Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.[1][2]
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.[2]
Interactions
AGTRAP has been shown to interact with GNB2L1.[1]
References
- ↑ 1.0 1.1 "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)". Int J Biochem Cell Biol 34 (1): 93–102. Dec 2001. doi:10.1016/S1357-2725(01)00094-2. PMID 11733189.
- ↑ 2.0 2.1 "Entrez Gene: AGTRAP angiotensin II receptor-associated protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57085.
External links
- Human AGTRAP genome location and AGTRAP gene details page in the UCSC Genome Browser.
Further reading
- "Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor". J. Biol. Chem. 274 (24): 17058–62. 1999. doi:10.1074/jbc.274.24.17058. PMID 10358057.
- "ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth". Biochem. Biophys. Res. Commun. 279 (3): 938–41. 2001. doi:10.1006/bbrc.2000.4055. PMID 11162453.
- "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. 2002. PMID 12107413.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling". Mol. Biol. Cell 14 (12): 5038–50. 2004. doi:10.1091/mbc.E03-06-0383. PMID 12960423.
- "Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane". Biochem. Biophys. Res. Commun. 310 (4): 1254–65. 2003. doi:10.1016/j.bbrc.2003.09.154. PMID 14559250.
- "A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells". J. Biol. Chem. 279 (20): 21109–20. 2004. doi:10.1074/jbc.M401544200. PMID 14985364.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation". J. Biol. Chem. 280 (13): 12536–41. 2005. doi:10.1074/jbc.M500296200. PMID 15668245.
- "The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy". FEBS Lett. 579 (7): 1579–86. 2005. doi:10.1016/j.febslet.2005.01.068. PMID 15757644.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
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