Biology:AKAP8
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene.[1][2]
Function
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining it to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is redistributed to distinct locations during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA.[2]
Interactions
AKAP8 has been demonstrated to interact with:
References
- ↑ 1.0 1.1 "Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95". Exp Cell Res 238 (2): 305–16. Mar 1998. doi:10.1006/excr.1997.3855. PMID 9473338.
- ↑ 2.0 2.1 "Entrez Gene: AKAP8 A kinase (PRKA) anchor protein 8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10270.
- ↑ "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95". Biochem. J. 378 (Pt 2): 673–9. Mar 2004. doi:10.1042/BJ20031765. PMID 14641107.
- ↑ "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase". J. Biol. Chem. 276 (20): 17448–54. May 2001. doi:10.1074/jbc.M101171200. PMID 11279182.
- ↑ "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem. 278 (29): 26750–6. Jul 2003. doi:10.1074/jbc.M300765200. PMID 12740381.
- ↑ "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem. 277 (52): 50885–92. Dec 2002. doi:10.1074/jbc.M206387200. PMID 12414807.
- ↑ "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis". J. Cell Biol. 147 (6): 1167–80. Dec 1999. doi:10.1083/jcb.147.6.1167. PMID 10601332.
Further reading
- "Anchoring and scaffold proteins for kinases and phosphatases.". Recent Prog. Horm. Res. 52: 409–29; discussion 429–30. 1997. PMID 9238861.
- "AKAP mediated signal transduction.". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. 2002. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
- "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis.". J. Cell Biol. 147 (6): 1167–80. 2000. doi:10.1083/jcb.147.6.1167. PMID 10601332.
- "A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract.". J. Cell Biol. 149 (3): 531–6. 2000. doi:10.1083/jcb.149.3.531. PMID 10791967.
- "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase.". J. Biol. Chem. 276 (20): 17448–54. 2001. doi:10.1074/jbc.M101171200. PMID 11279182.
- "Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting.". EMBO Rep. 3 (5): 426–32. 2002. doi:10.1093/embo-reports/kvf089. PMID 11964380.
- "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex.". J. Biol. Chem. 277 (52): 50885–92. 2003. doi:10.1074/jbc.M206387200. PMID 12414807.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication.". J. Biol. Chem. 278 (29): 26750–6. 2003. doi:10.1074/jbc.M300765200. PMID 12740381.
- "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95.". Biochem. J. 378 (Pt 2): 673–9. 2004. doi:10.1042/BJ20031765. PMID 14641107.
- "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. 2004. doi:10.1038/ncb1086. PMID 14743216.
- "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. 2004. doi:10.1038/nature02399. PMID 15057824. Bibcode: 2004Natur.428..529G.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association.". Mol. Cell. Biol. 25 (21): 9469–77. 2005. doi:10.1128/MCB.25.21.9469-9477.2005. PMID 16227597.
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. 2006. doi:10.1038/nbt1240. PMID 16964243.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
External links
- AKAP8 human gene location in the UCSC Genome Browser.
- AKAP8 human gene details in the UCSC Genome Browser.
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