Biology:ANTXR1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Anthrax toxin receptor 1 (ANTXR1 or also known asTEM8) is a protein that in humans is encoded by the ANTXR1 gene. Its molecular weight is predicted as about 63kDa.

The protein encoded by this gene is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.

See also

• Anthrax toxin

External links

• Human ANTXR1 genome location and ANTXR1 gene details page in the UCSC Genome Browser.
• Human ATR genome location and ATR gene details page in the UCSC Genome Browser.

Further reading

• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4". Biochemistry 38 (44): 14711–7. 1999. doi:10.1021/bi991614n. PMID 10545197. 
• "Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein". J. Biol. Chem. 276 (49): 46326–32. 2002. doi:10.1074/jbc.M108930200. PMID 11574549. 
• "Identification of the cellular receptor for anthrax toxin". Nature 414 (6860): 225–9. 2001. doi:10.1038/n35101999. PMID 11700562. 
• "UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts". Oncogene 20 (46): 6784–93. 2001. doi:10.1038/sj.onc.1204883. PMID 11709713. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor". Proc. Natl. Acad. Sci. U.S.A. 100 (9): 5170–4. 2003. doi:10.1073/pnas.0431098100. PMID 12700348. Bibcode: 2003PNAS..100.5170S. 
• "Binding of anthrax toxin to its receptor is similar to alpha integrin-ligand interactions". J. Biol. Chem. 278 (49): 49342–7. 2004. doi:10.1074/jbc.M307900200. PMID 14507921. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes". Oncogene 23 (10): 1911–21. 2004. doi:10.1038/sj.onc.1207318. PMID 14755251. 
• "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. 2005. doi:10.1186/gb-2004-5-2-r8. PMID 14759258. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection". Am. J. Physiol., Cell Physiol. 288 (6): C1402–10. 2005. doi:10.1152/ajpcell.00582.2004. PMID 15689409. 
• "TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen". Exp. Cell Res. 305 (1): 133–44. 2005. doi:10.1016/j.yexcr.2004.12.025. PMID 15777794. 
• "TEM-8 and tubule formation in endothelial cells, its potential role of its vW/TM domains". Biochem. Biophys. Res. Commun. 334 (1): 231–8. 2005. doi:10.1016/j.bbrc.2005.06.085. PMID 15993844. 
• "Receptor-specific requirements for anthrax toxin delivery into cells". Proc. Natl. Acad. Sci. U.S.A. 102 (37): 13278–83. 2005. doi:10.1073/pnas.0505865102. PMID 16141341. Bibcode: 2005PNAS..10213278R. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.