Biology:AP2S1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene.[1][2][3]
One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.[3]
References
- ↑ "Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2→q13.3". Cytogenet Cell Genet 75 (2–3): 132–5. Mar 1997. doi:10.1159/000134463. PMID 9040778.
- ↑ "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene 220 (1–2): 39–44. Nov 1998. doi:10.1016/S0378-1119(98)00406-5. PMID 9767099.
- ↑ 3.0 3.1 "Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1175.
Further reading
- "Clathrin coat construction in endocytosis". Curr. Opin. Struct. Biol. 10 (2): 220–8. 2000. doi:10.1016/S0959-440X(00)00071-3. PMID 10753805.
- "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "A Conserved Dileucine Motif Mediates Clathrin and AP-2–dependent Endocytosis of the HIV-1 Envelope Protein". Mol. Biol. Cell 18 (2): 414–25. 2007. doi:10.1091/mbc.E06-06-0535. PMID 17108326.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2". Virology 342 (2): 190–200. 2006. doi:10.1016/j.virol.2005.08.001. PMID 16139856.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "HIV-1 Tat Enters T Cells Using Coated Pits before Translocating from Acidified Endosomes and Eliciting Biological Responses". Mol. Biol. Cell 15 (5): 2347–60. 2005. doi:10.1091/mbc.E03-12-0921. PMID 15020715.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Molecular architecture and functional model of the endocytic AP2 complex". Cell 109 (4): 523–35. 2002. doi:10.1016/S0092-8674(02)00735-3. PMID 12086608.
- "Interactions of the Cytoplasmic Domains of Human and Simian Retroviral Transmembrane Proteins with Components of the Clathrin Adaptor Complexes Modulate Intracellular and Cell Surface Expression of Envelope Glycoproteins". J. Virol. 73 (2): 1350–61. 1999. doi:10.1128/JVI.73.2.1350-1361.1999. PMID 9882340.
- "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. 131 (3): 619–30. 1995. doi:10.1083/jcb.131.3.619. PMID 7593184.
- "Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2". Proc. Natl. Acad. Sci. U.S.A. 86 (8): 2612–6. 1989. doi:10.1073/pnas.86.8.2612. PMID 2495531. Bibcode: 1989PNAS...86.2612K.
- "AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast". J. Biol. Chem. 266 (17): 11153–7. 1991. doi:10.1016/S0021-9258(18)99141-6. PMID 2040623.
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External links
- Human AP2S1 genome location and AP2S1 gene details page in the UCSC Genome Browser.
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