Biology:ARNT2
 Generic protein structure example |
Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.[1][2]
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.[2]
References
- ↑ "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics 72 (1): 88–98. Mar 2001. doi:10.1006/geno.2000.6466. PMID 11247670.
- ↑ 2.0 2.1 "Entrez Gene: ARNT2 aryl-hydrocarbon receptor nuclear translocator 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9915.
External links
- Human ARNT2 genome location and ARNT2 gene details page in the UCSC Genome Browser.
Further reading
- "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. 1997. doi:10.1093/dnares/4.2.141. PMID 9205841.
- "Different transcriptional properties of mSim-1 and mSim-2.". FEBS Lett. 466 (1): 80–6. 2000. doi:10.1016/S0014-5793(99)01750-0. PMID 10648817.
- "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts.". Teratology 66 (2): 85–90. 2003. doi:10.1002/tera.10062. PMID 12210012.
- "Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells.". Blood 100 (7): 2623–8. 2002. doi:10.1182/blood-2001-12-0169. PMID 12239177.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression.". Mol. Cell. Biol. 24 (2): 608–16. 2004. doi:10.1128/MCB.24.2.608-616.2004. PMID 14701734.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. 2006. doi:10.1093/nar/gkj139. PMID 16381901.
- "Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription.". Biochem. Biophys. Res. Commun. 363 (1): 113–8. 2007. doi:10.1016/j.bbrc.2007.08.108. PMID 17826745.
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