Biology:ASRGL1
 Generic protein structure example |
L-asparaginase is an enzyme that in humans is encoded by the ASRGL1 gene.[1]
Function
The ASRGL1 protein consists of 308 amino acids and is activated by autocleavage at amino acid 168 to form an alpha- and a beta-chain, which can dimerize into a heterodimer.[2] The ASRGL1 enzyme has both L-asparaginase and beta-aspartyl peptidase activity and may be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions.
According to antibody-based profiling and transcriptomics analysis, ASRGL1 protein is present in all analysed human tissues, with highest expression in brain, in female tissues such as the uterine cervix and fallopian tube, and in male tissues as testis.[3] Based on confocal microscopy ASRGL1 is mainly localized to the microtubules.[4]
Clinical significance
ASRGL1 is highly expressed in the normal endometrium and differentially expressed in endometrial cancer. Loss of ASRGL1 expression is an unfavorable prognostic feature for patients with endometrial cancer.[5][6]
References
- ↑ "Entrez Gene: ASRGL1 asparaginase like 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80150.
- ↑ Li, Wenzong; Cantor, Jason R.; Yogesha, S. D.; Yang, Shirley; Chantranupong, Lynne; Liu, June Qingxia; Agnello, Giulia; Georgiou, George et al. (2012-11-16). "Uncoupling Intramolecular Processing and Substrate Hydrolysis in the N-Terminal Nucleophile Hydrolase hASRGL1 by Circular Permutation". ACS Chemical Biology 7 (11): 1840–1847. doi:10.1021/cb300232n. ISSN 1554-8929. PMID 22891768.
- ↑ "Tissue expression of ASRGL1 - Summary - The Human Protein Atlas". https://www.proteinatlas.org/ENSG00000162174-ASRGL1/tissue.
- ↑ "Cell atlas - ASRGL1 - The Human Protein Atlas". https://www.proteinatlas.org/ENSG00000162174-ASRGL1/cell.
- ↑ "Expression of ASRGL1 in endometrial cancer - The Human Protein Atlas". https://www.proteinatlas.org/ENSG00000162174-ASRGL1/pathology/tissue/endometrial+cancer.
- ↑ Edqvist, Per-Henrik D.; Huvila, Jutta; Forsström, Björn; Talve, Lauri; Carpén, Olli; Salvesen, Helga B.; Krakstad, Camilla; Grénman, Seija et al. (2015). "Loss of ASRGL1 expression is an independent biomarker for disease-specific survival in endometrioid endometrial carcinoma". Gynecologic Oncology 137 (3): 529–537. doi:10.1016/j.ygyno.2015.03.055. PMID 25858696.
External links
- ASRGL1 expression in the Human Protein Atlas
- Human ASRGL1 genome location and ASRGL1 gene details page in the UCSC Genome Browser.
Further reading
- "Identification of genes related to Parkinson's disease using expressed sequence tags". DNA Res. 13 (6): 275–86. 2006. doi:10.1093/dnares/dsl016. PMID 17213182.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "A novel asparaginase-like protein is a sperm autoantigen in rats". Mol. Reprod. Dev. 62 (2): 233–47. 2002. doi:10.1002/mrd.10092. PMID 11984834.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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