Biology:ATP6AP1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
The human gene ATP6AP1 encodes the S1 subunit of the enzyme V-type proton ATPase.[1][2][3]
This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is composed of a cytosolic, V1, (site of the ATP catalytic site) and a transmembrane, V0, domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules.[3]
References
- ↑ "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci". Hum Mol Genet 5 (5): 659–68. Jun 1997. doi:10.1093/hmg/5.5.659. PMID 8733135.
- ↑ "Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection". Hum Mol Genet 2 (11): 1865–9. Feb 1994. doi:10.1093/hmg/2.11.1865. PMID 8281148.
- ↑ 3.0 3.1 "Entrez Gene: ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=537.
External links
- Human ATP6AP1 genome location and ATP6AP1 gene details page in the UCSC Genome Browser.
Further reading
- "The vacuolar H+-ATPase: a universal proton pump of eukaryotes". Biochem. J. 324 (3): 697–712. 1997. doi:10.1042/bj3240697. PMID 9210392.
- "Structure, function and regulation of the vacuolar (H+)-ATPase". Annu. Rev. Cell Dev. Biol. 13: 779–808. 1998. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
- "Vacuolar and plasma membrane proton-adenosinetriphosphatases". Physiol. Rev. 79 (2): 361–85. 1999. doi:10.1152/physrev.1999.79.2.361. PMID 10221984.
- Forgac M (1999). "Structure and properties of the vacuolar (H+)-ATPases". J. Biol. Chem. 274 (19): 12951–4. doi:10.1074/jbc.274.19.12951. PMID 10224039.
- Kane PM (1999). "Introduction: V-ATPases 1992-1998". J. Bioenerg. Biomembr. 31 (1): 3–5. doi:10.1023/A:1001884227654. PMID 10340843.
- "Animal plasma membrane energization by proton-motive V-ATPases". BioEssays 21 (8): 637–48. 1999. doi:10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W. PMID 10440860.
- "Isolation of expressed sequences encoded by the human Xq terminal portion using microclone probes generated by laser microdissection". Genomics 20 (3): 404–11. 1994. doi:10.1006/geno.1994.1194. PMID 8034313.
- "Biosynthesis of the vacuolar H+-ATPase accessory subunit Ac45 in Xenopus pituitary". Eur. J. Biochem. 262 (2): 484–91. 1999. doi:10.1046/j.1432-1327.1999.00396.x. PMID 10336633.
- "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Fibroblast growth factor-10 is a mitogen for urothelial cells". J. Biol. Chem. 277 (26): 23828–37. 2002. doi:10.1074/jbc.M201658200. PMID 11923311.
- "ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6919–24. 2002. doi:10.1073/pnas.102025999. PMID 11983866.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
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