Biology:adipocyte protein 2

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens

A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

aP2 (adipocyte Protein 2)[1] is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs[2] has the possibility of treating heart disease and the metabolic syndrome.[3]

See also

References

  1. "Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA". Biochemistry 28 (22): 8683–90. 1989. doi:10.1021/bi00448a003. PMID 2481498. 
  2. "Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review". European Journal of Medicinal Chemistry 138: 854–873. September 2017. doi:10.1016/j.ejmech.2017.07.022. PMID 28738306. 
  3. "Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases". Journal of Atherosclerosis and Thrombosis 26 (3): 216–232. March 2019. doi:10.5551/jat.48710. PMID 30726793. 

External links

  • FABP4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
  • Human FABP4 genome location and FABP4 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Fatty acid-binding protein, adipocyte
  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Fatty acid-binding protein, adipocyte