Biology:Aldehyde dehydrogenase (NAD(P)+)
aldehyde dehydrogenase [NAD(P)+] | |||||||||
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Identifiers | |||||||||
EC number | 1.2.1.5 | ||||||||
CAS number | 9028-88-0 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) is an enzyme that catalyzes the chemical reaction
- an aldehyde + NAD(P)+ + H2O [math]\displaystyle{ \rightleftharpoons }[/math] an acid + NAD(P)H + H+
The 4 substrates of this enzyme are aldehyde, NAD+, NADP+, and H2O, whereas its 4 products are acid, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aldehyde:NAD(P)+ oxidoreductase. Other names in common use include aldehyde dehydrogenase [NAD(P)+], and ALDH. This enzyme participates in 5 metabolic pathways: glycolysis / gluconeogenesis, histidine metabolism, tyrosine metabolism, phenylalanine metabolism, and metabolism of xenobiotics by cytochrome p450.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1AD3, 1EYY, 1EZ0, and 2AMF.
References
- Black S (1951). "Yeast aldehyde dehydrogenase". Arch. Biochem. Biophys. 34 (1): 86–97. doi:10.1016/S0003-9861(51)80013-4. PMID 14904038.
- Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
- "Oxidation of acetaldehyde by Acetobacter suboxydans". J. Biol. Chem. 220 (1): 177–91. 1956. PMID 13319337.
- "Yeast aldehyde dehydrogenase. I. Purification and crystallization". J. Biol. Chem. 242 (21): 5019–23. 1967. PMID 4293780.
- Tanenbaum SW (1956). "The metabolism of Acetobacter peroxidans. I. Oxidative enzymes". Biochim. Biophys. Acta 21 (2): 335–342. doi:10.1016/0006-3002(56)90017-8. PMID 13363916.
![]() | Original source: https://en.wikipedia.org/wiki/Aldehyde dehydrogenase (NAD(P)+).
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