Biology:BAG5
 Generic protein structure example |
BAG family molecular chaperone regulator 5 is a protein that in humans is encoded by the BAG5 gene.[1][2][3]
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.[3]
References
- ↑ "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J Biol Chem 274 (2): 781–6. Feb 1999. doi:10.1074/jbc.274.2.781. PMID 9873016.
- ↑ "BAG5 inhibits parkin and enhances dopaminergic neuron degeneration". Neuron 44 (6): 931–45. Dec 2004. doi:10.1016/j.neuron.2004.11.026. PMID 15603737.
- ↑ 3.0 3.1 "Entrez Gene: BAG5 BCL2-associated athanogene 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9529.
External links
- Human BAG5 genome location and BAG5 gene details page in the UCSC Genome Browser.
Further reading
- "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity". Cell 80 (2): 279–84. 1995. doi:10.1016/0092-8674(95)90410-7. PMID 7834747.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1". EMBO J. 16 (20): 6209–16. 1997. doi:10.1093/emboj/16.20.6209. PMID 9321400.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. 1999. doi:10.1093/dnares/5.6.355. PMID 10048485.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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