Biology:BEX4
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Short description: Mammalian protein found in humans
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 Generic protein structure example |
Brain expressed, X-linked 4 is a protein that in humans is encoded by the BEX4 gene.[1]
This gene is a member of the brain expressed X-linked gene family. Proteins encoded by other members of this family act as transcription elongation factors that allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants encoding the same protein have been identified.[1]
References
Further reading
- "Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer". Oncogene 24 (32): 5089–5100. July 2005. doi:10.1038/sj.onc.1208700. PMID 15870691.
- "Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma". Journal of Experimental & Clinical Cancer Research 35 (1). June 2016. doi:10.1186/s13046-016-0355-6. PMID 27297407.
- "Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition". Cell Death & Disease 7 (8): e2336. August 2016. doi:10.1038/cddis.2016.240. PMID 27512957.
- "BEX4 upregulation alters Sertoli cell growth properties and protein expression profiles: An explanation for cadmium-induced testicular Sertoli cell injury". Journal of Biochemical and Molecular Toxicology 31 (7). July 2017. doi:10.1002/jbt.21908. PMID 28295929.
- "mTOR up-regulation of BEX4 promotes lung adenocarcinoma cell proliferation by potentiating OCT4". Biochemical and Biophysical Research Communications 500 (2): 302–309. June 2018. doi:10.1016/j.bbrc.2018.04.064. PMID 29660335. Bibcode: 2018BBRC..500..302Z.
- "Oncogenic potential of BEX4 is conferred by Polo-like kinase 1-mediated phosphorylation". Experimental & Molecular Medicine 50 (10): 1–12. October 2018. doi:10.1038/s12276-018-0168-0. PMID 30367032.
- "Aberrant brain-expressed X-linked 4 (BEX4) expression is a novel prognostic biomarker in gastric cancer". Medicine 99 (47). November 2020. doi:10.1097/MD.0000000000023133. PMID 33217815.
- "BEX1 and BEX4 Induce GBM Progression through Regulation of Actin Polymerization and Activation of YAP/TAZ Signaling". International Journal of Molecular Sciences 22 (18): 9845. September 2021. doi:10.3390/ijms22189845. PMID 34576008.
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