Biology:BRINP3

Generic protein structure example

BMP/retinoic acid inducible neural specific 3 is a protein that in humans is encoded by the BRINP3 gene.

Function

This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].

Further reading

• "Bone morphogenetic protein and retinoic acid-inducible neural specific protein-3 is expressed in gonadotrope cell pituitary adenomas and induces proliferation, migration, and invasion". Endocrinology 148 (3): 967–75. March 2007. doi:10.1210/en.2006-0905. PMID 17138656. 
• "Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study". BMC Med. Genet. 8 Suppl 1: S2. September 2007. doi:10.1186/1471-2350-8-S1-S2. PMID 17903301. 
• "Genetic and functional association of FAM5C with myocardial infarction". BMC Med. Genet. 9: 33. April 2008. doi:10.1186/1471-2350-9-33. PMID 18430236. 
• "Genetic and functional association of FAM5C with myocardial infarction". BMC Med. Genet. 9: 33. April 2008. doi:10.1186/1471-2350-9-33. PMID 18430236. 
• "Expression of the FAM5C in tongue squamous cell carcinoma". Oncol. Rep. 22 (5): 1005–11. November 2009. doi:10.3892/or_00000528. PMID 19787213. 
• "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. 2010. doi:10.2119/molmed.2009.00159. PMID 20379614. 
• "FAM5C contributes to aggressive periodontitis". PLOS ONE 5 (4): e10053. April 2010. doi:10.1371/journal.pone.0010053. PMID 20383335. Bibcode: 2010PLoSO...510053C. 
• "FAM5C contributes to aggressive periodontitis". PLOS ONE 5 (4): e10053. April 2010. doi:10.1371/journal.pone.0010053. PMID 20383335. Bibcode: 2010PLoSO...510053C. 
• "The relationships between FAM5C SNP (rs10920501) variability and metabolic syndrome and inflammation in women with coronary heart disease". Biol Res Nurs 15 (2): 160–6. April 2013. doi:10.1177/1099800411424487. PMID 22013132. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.