Biology:BTAF1
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TATA-binding protein-associated factor 172 is a protein that in humans is encoded by the BTAF1 gene.[1][2][3]
Function
Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP; MIM 600075) and TBP-associated factors, or TAFs (e.g., TAF2B; MIM 604912), in 2 distinct complexes, TFIID and B-TFIID. The TFIID complex is composed of TBP and more than 8 TAFs. However, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170, also called TAF172, and has DNA-dependent ATPase activity.[supplied by OMIM][3]
Interactions
BTAF1 has been shown to interact with TATA binding protein.[2][4]
References
- ↑ "Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila". Proc Natl Acad Sci U S A 94 (22): 11827–32. Dec 1997. doi:10.1073/pnas.94.22.11827. PMID 9342322.
- ↑ 2.0 2.1 "Cloning and Biochemical Characterization of TAF-172, a Human Homolog of Yeast Mot1". Mol Cell Biol 18 (3): 1701–10. Mar 1998. doi:10.1128/MCB.18.3.1701. PMID 9488487.
- ↑ 3.0 3.1 "Entrez Gene: BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9044.
- ↑ "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. May 1997. doi:10.1073/pnas.94.11.5605. PMID 9159119.
External links
- Human BTAF1 genome location and BTAF1 gene details page in the UCSC Genome Browser.
Further reading
- "Novel mechanism and factor for regulation by HIV-1 Tat". EMBO J. 14 (2): 321–8. 1995. doi:10.1002/j.1460-2075.1995.tb07006.x. PMID 7835343.
- "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro". J. Biol. Chem. 270 (5): 2274–83. 1995. doi:10.1074/jbc.270.5.2274. PMID 7836461.
- "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function". J. Virol. 68 (11): 7188–99. 1994. doi:10.1128/JVI.68.11.7188-7199.1994. PMID 7933101.
- "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature 367 (6460): 295–9. 1994. doi:10.1038/367295a0. PMID 8121496.
- "Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (2): 128–38. 1996. doi:10.1097/00042560-199606010-00005. PMID 8680883.
- "Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly". J. Virol. 70 (8): 5025–34. 1996. doi:10.1128/JVI.70.8.5025-5034.1996. PMID 8764009.
- "Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex". J. Virol. 70 (8): 5503–10. 1996. doi:10.1128/JVI.70.8.5503-5510.1996. PMID 8764062.
- "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science 274 (5287): 605–10. 1996. doi:10.1126/science.274.5287.605. PMID 8849451. Bibcode: 1996Sci...274..605Z.
- "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. 1997. doi:10.1074/jbc.272.11.6951. PMID 9054383.
- "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. 1997. doi:10.1073/pnas.94.11.5605. PMID 9159119.
- "The gene for human TATA-binding-protein-associated factor (TAFII) 170: structure, promoter and chromosomal localization". Biochem. J. 345 (3): 521–7. 2000. doi:10.1042/0264-6021:3450521. PMID 10642510.
- "Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation". Biochem. Biophys. Res. Commun. 302 (4): 735–42. 2003. doi:10.1016/S0006-291X(03)00226-2. PMID 12646231.
- "Molecular architecture of the basal transcription factor B-TFIID". J. Biol. Chem. 279 (21): 21802–7. 2004. doi:10.1074/jbc.M313519200. PMID 14988402.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "NC2α Interacts with BTAF1 and Stimulates Its ATP-Dependent Association with TATA-Binding Protein". Mol. Cell. Biol. 24 (22): 10072–82. 2004. doi:10.1128/MCB.24.22.10072-10082.2004. PMID 15509807.
- "Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues". Structure 14 (3): 511–20. 2006. doi:10.1016/j.str.2005.11.020. PMID 16531235.
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