Biology:Basic amino acid antiporter family

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Short description: Family of transport proteins

The Basic Amino Acid Antiporter (ArcD) family (TC# 2.A.118) is a constituent of the IT superfamily.[1][2][3] This family consists of proteins from Gram-negative and Gram-positive bacteria (e.g., Streptococcus, Escherichia, Salmonella, Fusobacterium and Borrelia species). The proteins are of about 480 amino acyl residues (aas) in length and have 10-12 putative transmembrane segments (TMSs). Functionally characterized homologues are in the DcuC (TC #2.A.61) and ArsB (TC #2.A.4) families. Some members of the family probably catalyze arginine/ornithine or citrulline/ornithine antiport.[4][5]

See also

References

  1. ↑ Lolkema, Juke S.; Slotboom, Dirk Jan (2003-04-11). "Classification of 29 families of secondary transport proteins into a single structural class using hydropathy profile analysis". Journal of Molecular Biology 327 (5): 901–909. doi:10.1016/s0022-2836(03)00214-6. ISSN 0022-2836. PMID 12662917. https://pure.rug.nl/ws/files/6669968/2003JMolBiolLolkema.pdf. 
  2. ↑ Prakash, Shraddha; Cooper, Garret; Singhi, Soumya; Saier, Milton H. (2003-12-03). "The ion transporter superfamily". Biochimica et Biophysica Acta (BBA) - Biomembranes 1618 (1): 79–92. doi:10.1016/j.bbamem.2003.10.010. ISSN 0006-3002. PMID 14643936. 
  3. ↑ Rabus, R.; Jack, D. L.; Kelly, D. J.; Saier, M. H. (1999-12-01). "TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters". Microbiology 145 ( Pt 12) (12): 3431–3445. doi:10.1099/00221287-145-12-3431. ISSN 1350-0872. PMID 10627041. 
  4. ↑ Gupta, Radha; Yang, Jun; Dong, Yimin; Swiatlo, Edwin; Zhang, Jing-Ren; Metzger, Dennis W.; Bai, Guangchun (2013-10-01). "Deletion of arcD in Streptococcus pneumoniae D39 impairs its capsule and attenuates virulence". Infection and Immunity 81 (10): 3903–3911. doi:10.1128/IAI.00778-13. ISSN 1098-5522. PMID 23918778. 
  5. ↑ Rimaux, Tom; Rivière, Audrey; Hebert, Elvira María; Mozzi, Fernanda; Weckx, Stefan; De Vuyst, Luc; Leroy, Frédéric (2013-04-01). "A putative transport protein is involved in citrulline excretion and re-uptake during arginine deiminase pathway activity by Lactobacillus sakei". Research in Microbiology 164 (3): 216–225. doi:10.1016/j.resmic.2012.11.004. ISSN 1769-7123. PMID 23178175. 


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