Biology:Bicoid 3′-UTR regulatory element
From HandWiki
| Bicoid 3′-UTR regulatory element | |
|---|---|
 | |
| Identifiers | |
| Symbol | bcd |
| Rfam | RF00551 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Insecta |
| PDB structures | PDBe |
The bicoid 3′-UTR regulatory element is an mRNA regulatory element that controls the gene expression of the bicoid protein in fruitfly Drosophila melanogaster.
The structured RNA element consists of four domains (denoted as II, III, IV and V) in the 3′UTR of the mRNA. It is essential for the correct transport and localisation of bicoid mRNA during oocyte and embryo differentiation, which has been studied most thoroughly in the development of Drosophila melanogaster (fruitfly) larvae.[1][2][3][4]
References
- ↑ "cis-acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos". Nature 336 (6199): 595–598. December 1988. doi:10.1038/336595a0. PMID 3143913. Bibcode: 1988Natur.336..595M.
- ↑ "bicoid mRNA localization signal: phylogenetic conservation of function and RNA secondary structure". Development 110 (1): 161–171. September 1990. doi:10.1242/dev.110.1.161. PMID 2081457.
- ↑ "Molecular analysis of the bicoid gene from Drosophila pseudoobscura: identification of conserved domains within coding and noncoding regions of the bicoid mRNA". The EMBO Journal 9 (9): 2977–2987. September 1990. doi:10.1002/j.1460-2075.1990.tb07490.x. PMID 1975239.
- ↑ "Secondary structure of the 3′ UTR of bicoid mRNA". Biochimie 86 (2): 91–104. February 2004. doi:10.1016/j.biochi.2004.01.002. PMID 15016447.
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