Biology:BolA-like protein family
| BolA | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 solution structure of protein yrba from escherichia coli: northeast structural genomics consortium target er115 | |||||||||
| Identifiers | |||||||||
| Symbol | BolA | ||||||||
| Pfam | PF01722 | ||||||||
| InterPro | IPR002634 | ||||||||
| SCOP2 | 1v9j / SCOPe / SUPFAM | ||||||||
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In molecular biology, the BolA-like protein family consists of the morpho-protein BolA from Escherichia coli, the Fra2 protein from Saccharomyces cerevisiae, and various homologs. The BolA protein is a DNA-binding regulator;[1] the Fra2 protein is an iron sulfur cluster protein that binds Grx3/4 and is involved in regulating iron levels .[2]
In E. coli, over-expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division.[3] The expression of BolA is growth rate regulated and is induced during the transition into the stationary phase.[3] BolA is also induced by stress during early stages of growth [3] and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.[3][4]
References
- ↑ "BolA Is a Transcriptional Switch That Turns Off Motility and Turns On Biofilm Development". mBio 6 (1): e02352-14. 17 February 2015. doi:10.1128/mBio.02352-14. PMID 25691594.
- ↑ "The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S cluster with cysteinyl and histidyl ligation"]. Biochemistry 48 (40): 9569–81. 2009. doi:10.1021/bi901182w. PMID 19715344.
- ↑ 3.0 3.1 3.2 3.3 "The stationary-phase morphogene bolA from Escherichia coli is induced by stress during early stages of growth". Mol. Microbiol. 32 (4): 789–98. May 1999. doi:10.1046/j.1365-2958.1999.01397.x. PMID 10361282.
- ↑ "Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene". EMBO J. 8 (12): 3923–31. December 1989. doi:10.1002/j.1460-2075.1989.tb08573.x. PMID 2684651.
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