Biology:Brown greater galago prosimian foamy virus

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Short description: Species of retrovirus

Prosimiispumavirus otocra
A brown greater galago
Virus classification
Group:
Group VI (ssRNA-RT)
Order:
Ortervirales
Family:
Retroviridae
Subfamily:
Spumaretrovirinae
Genus:
Prosimiispumavirus
Species:
Prosimiispumavirus otocra

Prosimiispumavirus otocra (PSFVgal), or Brown greater galago prosimian foamy virus, is a retrovirus and the sole species in the genus Prosimiispumavirus, belonging to the subfamily Spumaretrovirinae of the family Retroviridae.[1][2] Its natural host is the brown greater galago (Otolemur crassicaudatus), a strepsirrhine primate from southern Africa, from which the species epithet otocra is derived. It is the only known exogenous foamy virus with a prosimian host, altough traces of ancient foamy viruses have been found in the genomes of other prosimians as endogenous foamy viruses[3][4]

Taxonomy

The complete genome of P. otocrawas reported in 2014 after being isolated from a galago.[4] In 2017, the International Committee on Taxonomy of Viruses reorganized the former single genus Spumavirus into five host-range-reflecting genera, adopting the Prosimiispumavirus genus to accommodate this species.[5][2]

Phylogenetic analysis places P. otocra as a sister lineage to the simian foamy viruses (Simiispumavirus genus), consistent with the evolutionary split between prosimians and simians.[4] The transmission patterns of foamy virus diversification mirrors that of their mammalian hosts, supporting long-term cospeciation rather than recent host switching.[6][1]

Structure

Similar to other members of the subfamily Spumaretrovirinae, Prosimiispumavirus otocra has a genome length of 12,118 nucleotides, organized into a foamy virus structure with long terminal repeats flanking the gag, pol, and env genes, along with accessory genes bel1 (tas) and bel2 (bet).[4] No in-frame stop codons are present in the coding regions. Virions share the general spumaviral morphology.[7]

See also

References

  1. ↑ 1.0 1.1 "Genus: Prosimiispumavirus". International Committee on Taxonomy of Viruses. https://ictv.global/report/chapter/retroviridae/retroviridae/prosimiispumavirus. 
  2. ↑ 2.0 2.1 Mayer, Jens (2025). "2024 taxonomy update for the family Retroviridae". Archives of Virology 170 (8). doi:10.1007/s00705-025-06353-y. PMID 40576840. 
  3. ↑ Han, Guan-Zhu; Worobey, Michael (2012). "An Endogenous Foamy Virus in the Aye-Aye (Daubentonia madagascariensis)". Journal of Virology 86 (14): 7696–7698. doi:10.1128/JVI.00650-12. PMID 22573860. PMC 3416287. https://experts.arizona.edu/en/publications/an-endogenous-foamy-virus-in-the-aye-aye-daubentonia-madagascarie/. 
  4. ↑ 4.0 4.1 4.2 4.3 Katzourakis, Aris; Aiewsakun, Pakorn; Jia, Hongwei; Wolfe, Nathan D.; LeBreton, Matthew; Yoder, Anne D.; Switzer, William M. (2014). "Discovery of prosimian and afrotherian foamy viruses and potential cross species transmissions amidst stable and ancient mammalian co-evolution". Retrovirology 11. doi:10.1186/1742-4690-11-61. PMID 25091111. 
  5. ↑ Khan, Adeeba S. (2018). "Spumaretroviruses: Updated taxonomy and nomenclature". Virology 516: 158–164. doi:10.1016/j.virol.2018.01.005. PMID 29331866. 
  6. ↑ Switzer, William M. (2005). "Ancient co-speciation of simian foamy viruses and primates". Nature 434 (7031): 376–380. doi:10.1038/nature03341. PMID 15772660. Bibcode: 2005Natur.434..376S. 
  7. ↑ "Subfamily: Spumaretrovirinae". International Committee on Taxonomy of Viruses. https://ictv.global/report/chapter/retroviridae/retroviridae/spumaretrovirinae. 

Wikidata ☰ Q51928632 entry



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