Biology:C11orf91

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Short description: Protein


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Chromosome 11 open reading frame 91, or C11orf91 is a protein which in humans is encoded by the C11orf91 gene.

Gene

Conceptual translation of human C11orf91 gene/protein.

The C11orf91 gene consists of 5159 nucleotides with an mRNA of approximately 836 base pairs.[1][2] There is one exon found in the C11orf91 gene.

mRNA

The cytogenetic band location of C11orf91 is 11p13 and is located on the minus strand of the DNA .[3]

Conceptual translation

Annotated depiction of the C11orf91 mRNA and amino acid protein sequences.

Protein

Tertiary Structure of human C11orf91 protein. Created with AlphaFold Protein Structure Database.[4]

The C11orf91 gene encodes a protein that is 193 amino acids in length.[5][6] The C11orf91 protein contains a domain of unknown function, DUF5529, that spans nearly the entire protein. RBMX protein binding sites were found to be highly conserved in several structures of human C11orf91 3'UTR and 5' UTR.[7][8] C11orf91 is rich in serine and proline and poor in valine and asparagine.[9] There is a proline rich region found in the middle of the C11orf91.[10] The human C11orf91 protein is approximately 20 kDal and has an isoelectric point around 9.[11]

Localization

Human C11orf91 protein is predicted to be localized in vesicles.[12][13]

Structure

C11orf91 has two helices located near the C-terminus and no beta sheets.[14][15][16][17][18][19][20][excessive citations]

Post-translational modifications

C11orf91 has a predicted Protein kinase C (PKC) phosphorylation site, Casein kinase 2 (CK2) phosphorylation site, amidation site, and two predicted serine phosphorylation sites, see Conceptual Translation for post-translational modification site locations.[21][22][23][24]

Evolution

Corrected Sequence Divergence vs. Median Date of Divergence graph for human C11orf91, Fibrinogen Alpha, and Cytochrome C.

There are no paralogs of the human C11orf91 protein.[25][26] The human C11orf91 protein has several orthologs found across eight categories of jawed vertebrates including: aves, testudines, alligators, reptiles, mammals, amphibians, lungfishes, and cartilaginous fishes.[27]

Select Orthologs of C11orf91
Genus and Species Common Name Taxonomic Group Median Date of Divergence (MYA) Accession Number Sequence Length (aa) Sequence Identity to Human Protein (%) Sequence Similarity to Human Protein (%)
Homo sapeins Human Primates 0 XP_016872542.1 193 100 100
Mus musculus Mouse Rodentia 87 NP_080910.1 194 81.7 84.3
Equus caballus Horse Odd-toed ungulates 94 XP_023509601.1 191 87 89.1
Choloepus didactylus Southern two-toed sloth Pilosa 99 XP_037697448.1 191 86.2 87.2
Phascolarctos cinereus Koala Diprotodontia 160 XP_020819588.1 212 67.1 70.8
Gopherus evgoodei Goode's thornscrub tortoise Testudines 319 XP_030417986.1 163 46.5 55.5
Pogona vitticeps Central bearded dragon Squamata 319 XP_020663275.1 168 44.3 54.7
Sphaerodactylus townsendi Townsend's least gecko Squamata 319 XP_048340539.1 168 43 51.7
Alligator mississippiensis American alligator Crocodilia 319 XP_059577366.1 157 41.4 51.2
Tyto alba Barn owl Strigiformes 319 XP_042641164.1 143 34.5 41.5
Calypte anna Hummingbird Apodiformes 319 XP_030307391.1 146 32.3 44.6
Gymnogyps californianus California condor Accipitriformes 319 XP_050754406.1 142 32.2 38.8
Dryobates pubescens Downy woodpecker Piciformes 319 XP_054027854.1 143 32.1 43.5
Dromaius novaehollandiae Emu Struthioniformes 319 XP_025967391.1 209 29.6 35.8
Rhinatrema bivittatum Two-lined caecilians Caecilidae 352 XP_029438087.1 144 45.1 57
Pleurodeles waltl Iberian ribbed newt Caudata 352 KAJ1177600.1 140 40.1 52.3
Hyla sarda Sardinian tree frog Anura 352 XP_056384394.1 153 27.4 37
Protopterus annectens West African lungfish Lepidosireniformes 408 XP_043915714.1 173 28.5 37.4
Pygocentrus nattereri Red-bellied piranha Characiformes 429 XP_017546298.1 147 25.9 37.1
Amblyraja radiata Thorny skate Rajiformes 462 XP_032894439.1 136 37.7 46.2

References

  1. ↑ Human chromosome 11 open reading frame 91 (C11orf91), mRNA. NCBI Nucleotide. Retrieved 23 September 2023.
  2. ↑ Uncharacterized protein C11orf91 [Homo sapiens]. NCBI Protein. Retrieved 23 September 2023.
  3. ↑ C11orf91 Gene. Gene Cards. Retrieved 23 September 2023.
  4. ↑ AlphaFold Protein Structure Database. AlphaFold Protein Structure Database. Retrieved 5 December 2023.
  5. ↑ Homo sapiens chromosome 11 open reading frame 91 (C11orf91), mRNA. NCBI Nucleotide. Retrieved 23 September 2023.
  6. ↑ Uncharacterized protein C11orf91 [Homo sapiens]. NCBI Protein. Retrieved 23 September 2023.
  7. ↑ RNA Folding Form Tool. The UNAFold Web Server. Retrieved 5 December 2023.
  8. ↑ Predict Binding Sites from PWMs Tool. RBPDB.Retrieved 5 December 2023.
  9. ↑ Statistical Analysis of Protein Sequences Tool. European Bioinformatics Institute. Retrieved 5 December 2023.
  10. ↑ Homo sapiens chromosome 11 open reading frame 91 (C11orf91), mRNA. NCBI Nucleotide. Retrieved 5 December 2023.
  11. ↑ PhosphoSitePlus Tool. PhosphoSitPlus. Retrieved 15 December 2023.
  12. ↑ C11orf91 Polyclonal Antibody. ThermoFisher Scientific. Retrieved 5 December 2023.
  13. ↑ The Human Protein Atlas entry on C11orf91. Human Protein Atlas. Retrieved 5 December 2023.
  14. ↑ Chou & Fasman Secondary Structure Prediction Server. Biogem. Retrieved 5 December 2023.
  15. ↑ JPred 4: A Protein Secondary Structure Prediction Server. JPred 4. Retrieved 5 December 2023.
  16. ↑ Predict Protein Tool. Predictprotein. Retrieved 5 December 2023.
  17. ↑ Ali2D Tool. MPI Bioinformatics Toolkit. Retrieved 5 December 2023.
  18. ↑ I-TASSER Tool. The Yang Zhang Lab. Retrieved 5 December 2023.
  19. ↑ AlphaFold Protein Structure Database. AlphaFold Protein Structure Database. Retrieved 5 December 2023.
  20. ↑ NCBI Structure iCN3D. iCn3D: Web-based 3D Structure Viewer. Retrieved 5 December 2023.
  21. ↑ MyHits Motif Scan Tool. SIB Swiss Institute of Bioinformatics. Retrieved 5 December 2023.
  22. ↑ DTU Health Tech NetPhos 3.1 Tool. DTU Health Tech Department of Health Technology. Retrieved 5 December 2023.
  23. ↑ GPS 6.0. Group Based Prediction System. Retrieved 5 December 2023.
  24. ↑ PhosphoSitePlus Tool. Phosphosite. Retrieved 5 December 2023.
  25. ↑ (National Center for Biotechnology Information) Basic Local Alignment Search Tool. NCBI BLAST. Retrieved 5 December 2023.
  26. ↑ UCSC Genome Browser entry on Human GRCh38/hg38. UCSC Genome Browser. Retrieved 5 December 2023.
  27. ↑ NCBI (National Center for Biotechnology Information) entry on C11orf91 - chromosome 11 open reading frame 91 NCBI Orthologs . NCBI Protein. Retrieved 19 October 2023.



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